Mice are not little rats: species differences in a one-day water maze task.

Abstract:

:The present study examined species differences in spatial and non-spatial memory in the Morris water maze. Male Wistar rats and C57BL/6 mice were tested in a one-day water maze task in which spatial learning, retention, and non-spatial learning were assessed within 3 h. Rats and mice appeared to use different strategies for locating the hidden escape platform. Whereas rats evinced a clear spatial strategy, mice appeared to rely less on spatial cues and more on alternative non-spatial strategies. The sensitivity of this behavioral protocol to subtle species differences highlights the potential use of this one-day water maze task as a tool for evaluating rapidly learning and memory in rodents.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Frick KM,Stillner ET,Berger-Sweeney J

doi

10.1097/00001756-200011090-00013

subject

Has Abstract

pub_date

2000-11-09 00:00:00

pages

3461-5

issue

16

eissn

0959-4965

issn

1473-558X

journal_volume

11

pub_type

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