Abstract:
:Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system, and humoral immunity is suggested to play an important role in the pathogenesis. The identification of an anti-aquaporin-4 antibody (AQP4-Ab, neuromyelitis optica immunoglobulin G) in the sera of patients with NMO has led to the investigation on the pathogenicity of the autoantibody. Recent immunohistological analyses revealed the primary loss of AQP4 on astrocytes and complement deposition in active lesions of NMO. In this report, we show that astrocytes are susceptible to sera from AQP4-Ab-positive patients and undergo necrosis in a complement-dependent manner. Our results suggest the primary pathogenic role of AQP4-Ab in NMO.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kinoshita M,Nakatsuji Y,Moriya M,Okuno T,Kumanogoh A,Nakano M,Takahashi T,Fujihara K,Tanaka K,Sakoda Sdoi
10.1097/wnr.0b013e32832776f4subject
Has Abstractpub_date
2009-03-25 00:00:00pages
508-12issue
5eissn
0959-4965issn
1473-558Xjournal_volume
20pub_type
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