Interleukin-1ra inhibits Fos expression and hyperalgesia in rats.

abstract：:Prior work has shown that kappa opioids may attenuate the effects of analgesic mu receptor agonists in some neural circuits related to pain modulation. This study examined whether hypoalgesia following exposure to a signal for shock is attenuated by infusions of the kappa agonist U69593 into the rostral ventromedial m...

journal_title：Neuroreport

authors： Foo H,Helmstetter FJ

更新日期：2000-10-20 00:00:00

abstract：:The apolipoprotein E (apoE) gene has been identified as a susceptibility gene for Alzheimer's disease, although the mechanism whereby apoE exerts this effect has not been determined. The aim of this study was to examine the intracellular fate of apoE and we demonstrate that in mammalian cells-transiently expressing ta...

journal_title：Neuroreport

authors： Lovestone S,Anderton BH,Hartley C,Jensen TG,Jorgensen AL

更新日期：1996-04-10 00:00:00

abstract：:Clinical and experimental studies clearly demonstrate that prolonged seizures and status epilepticus induce neuronal cell death in the brain. Recent evidence suggests that induction of apoptosis contributes greatly to seizure-induced brain damage. We recently demonstrated that intrahippocampal delivery of botulinum ne...

journal_title：Neuroreport

authors： Manno I,Antonucci F,Caleo M,Bozzi Y

更新日期：2007-04-16 00:00:00

abstract：:Methamphetamine (METH)-induced dopaminergic neurotoxicity is associated with hyperthermia. We investigated the effect of several neuronal nitric oxide synthase (nNOS) inhibitors on METH-induced hyperthermia and striatal dopaminergic neurotoxicity. Administration of METH (5 mg/kg; q. 3 h x 3) to Swiss Webster mice prod...

journal_title：Neuroreport

authors： Itzhak Y,Martin JL,Ail SF

更新日期：2000-09-11 00:00:00

abstract：:Epilepsy is a neurological disorder with recurrent unprovoked seizures as the main symptom. Of the coumarin derivatives in Angelica gigas, decursin, a major coumarin component, was reported to exhibit significant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical...

journal_title：Neuroreport

authors： Lee JK,Jeong JW,Jang T,Lee GW,Han H,Kang JS,Kim IH

更新日期：2014-11-12 00:00:00

abstract：:The aim of the present study was to examine the effects of nicotinamide, a co-factor in the electron transport chain, on the relationship between methamphetamine (MA)-induced striatal dopamine (DA) depletion and energy metabolism change. Four injections of MA (10 mg/kg, i.p.) at 2 h intervals resulted in decreases of ...

journal_title：Neuroreport

authors： Huang NK,Wan FJ,Tseng CJ,Tung CS

更新日期：1997-05-27 00:00:00

abstract：:The present paper reports how aluminium [Al(III)] at a concentration of 3.7 microM can activate the bovine erythrocytic enzyme acetylcholinesterase (AChE) by about 38% in vitro. This same activating effect was observed on AChE form human as well as from rat erythrocyte ghosts and murine neuroblastoma cells. The intera...

journal_title：Neuroreport

authors： Zatta P,Zambenedetti P,Bruna V,Filippi B

更新日期：1994-09-08 00:00:00

abstract：:It has been previously demonstrated that members of the neurotrophin family may prevent death of motoneurones following axotomy. Here we report that the expression of mRNA for full-length trkB, which is a signal transducing receptor for BDNF and NT-4, increases transiently in spinal motoneurones after axotomy in adult...

journal_title：Neuroreport

authors： Piehl F,Frisén J,Risling M,Hökfelt T,Cullheim S

更新日期：1994-02-24 00:00:00

abstract：:Counter-stimulation reduces pain perception; however, the role of attention during this process is rarely discussed despite attention itself being a well known modulator of pain perception. This study investigated the effect of attentional modulation on pain perception during counter-stimulation using fMRI. Subjects r...

journal_title：Neuroreport

authors： Longe SE,Wise R,Bantick S,Lloyd D,Johansen-Berg H,McGlone F,Tracey I

更新日期：2001-07-03 00:00:00

abstract：:In order to assess effects of glucagon-like peptide-1 (GLP-1) in the brain excluding the hypothalamus, the effects of GLP-1 (7-36) amide, a naturally produced active fragment, on the electroencephalogram and hippocampal single unit activities of anesthetized male Wistar rats were examined. I.c.v. injection of GLP-1 (7...

journal_title：Neuroreport

authors： Oka JI,Goto N,Kameyama T

更新日期：1999-06-03 00:00:00

abstract：:This study used event-related functional magnetic resonance imaging to investigate the neural basis underlying the sequential involvement of syntactic processing in the course of sentence comprehension. In experiments, a noun, case particle, and verb were presented one by one, constituting simple sentences in Japanese...

journal_title：Neuroreport

authors： Ogawa K,Ohba M,Inui T

更新日期：2007-09-17 00:00:00

abstract：:Hemispheric differences in the temporal processing of musical sounds within the primary auditory cortex were investigated using functional magnetic resonance imaging (fMRI) time series analysis on a 3.0 T system in right-handed individuals who had no formal training in music. The two hemispheres exhibited a clear-cut ...

journal_title：Neuroreport

authors： Izumi S,Itoh K,Matsuzawa H,Takahashi S,Kwee IL,Nakada T

更新日期：2011-07-13 00:00:00

abstract：:Poly(ADP-ribose) polymerase-1 consumes NAD to catalyze poly(ADP-ribosyl)ation of target proteins, which modulates various biological functions. However, excessive poly(ADP-ribose) polymerase-1 activation mediates oxidative cell death. Our recent studies have indicated that NAD can enter into astrocytes to prevent poly...

journal_title：Neuroreport

authors： Zhu K,Swanson RA,Ying W

更新日期：2005-08-01 00:00:00

abstract：:We examined the induction of progesterone receptor-immunoreactive (PR-ir) cells by estrogen in the rat preoptic area and ventromedial hypothalamic nucleus. Ovariectomized young (3-month-old) and old (24-month-old) female rats were treated with estrogen or cholesterol for 4 days. Estrogen significantly increased PR-ir ...

journal_title：Neuroreport

authors： Furuta M,Fukushima A,Chiba S,Sano A,Akema T,Kimura F,Funabashi T

更新日期：2010-08-04 00:00:00

abstract：:To clarify possible interaction between the ventral hippocampal cannabinoid CB2 receptors and the cholinergic system in control of the memory process, the effects of cannabinoid and acetylcholine receptor agents on memory consolidation have been investigated in mice. Animals implanted with bilateral cannulas at the CA...

journal_title：Neuroreport

authors： Nasehi M,Forouzanmehr E,Khakpai F,Zarrindast MR

更新日期：2020-01-27 00:00:00

abstract：:The temperature of the tail skin is an important factor determining tail-flick latency to noxious radiant heat in rats and mice. The temperature of the skin may also be important in determining the behavioural response in the formalin test. Morphine in low and moderate doses strongly affected the core and tail skin te...

journal_title：Neuroreport

authors： Tjølsen A,Hole K

更新日期：1992-06-01 00:00:00

abstract：:This study aimed to examine the spontaneous hemodynamic fluctuations and the dysfunctional brain regions in patients with generalized anxiety disorder (GAD) using resting-state functional MRI. Previous studies have demonstrated some neural networks that are different in this patient group compared with healthy control...

journal_title：Neuroreport

authors： Li C,Su S,Wu H,Zhu Y

更新日期：2018-03-21 00:00:00

abstract：:Two well-known appetite-regulatory peptides, leptin and cocaine- and amphetamine-regulated transcript (CART), are known to be involved in the brain rewarding pathway. However, it is not yet known how they interact in the nucleus accumbens, an important region mediating the rewarding effects of drugs of abuse. Using th...

journal_title：Neuroreport

authors： Cho BR,Yoon HS,Kim WY,Vezina P,Kim JH

更新日期：2017-08-02 00:00:00

abstract：:Thyroid hormones, which play an important role in the development and regeneration of the nervous system, require the presence of specific nuclear T3 receptors (NT3R). In this study we provide evidence that NT3R expression by Schwann cells was up-regulated in response to a loss of axonal contact in vitro and in vivo. ...

journal_title：Neuroreport

authors： Walter IB

更新日期：1993-11-18 00:00:00

abstract：:Dopamine (DA) deficiency in Parkinson's disease is commonly treated with L-dihydroxyphenylalanine (L-dopa), the amino acid precursor to DA. L-dopa is neurotoxic in vitro and impairs survival of metabolically stressed neurons in vivo. We examined with microdialysis of substantia nigra in awake rats the local production...

journal_title：Neuroreport

authors： Smith TS,Parker WD Jr,Bennett JP Jr

更新日期：1994-04-14 00:00:00

abstract：:Benevolence is widespread in our societies. It is defined as considering a subordinate group nicely but condescendingly, that is, with charity. Deleterious consequences for the target have been reported in the literature. In this experiment, we used functional MRI (fMRI) to identify whether being the target of (sexist...

journal_title：Neuroreport

authors： Dardenne B,Dumont M,Sarlet M,Phillips C,Balteau E,Degueldre C,Luxen A,Salmon E,Maquet P,Collette F

更新日期：2013-07-10 00:00:00

abstract：:We investigated some in vitro pharmacological properties of a novel human dopamine D2-like receptor antagonist, YM-50001 [(R)-5-chloro-4-cyclopropylacarbonylamino-2-methoxy-N-[1-(3-methox ybenzyl)- 3-pyrrolidinyl]benzamide monooxalate]. Receptor binding studies revealed that YM-50001 had a potent affinity for human D4...

journal_title：Neuroreport

authors： Hidaka K,Tada S,Matsumoto M,Ohmori J,Maeno K,Yamaguchi T

更新日期：1996-11-04 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine the expression level of immunoproteasome and its clinical significance in glioma preliminarily. Furthermore, we studied the function and molecular mechanism of proteasome inhibitor ONX 0912 on glioma cell. MATERIALS AND METHODS:The expression of immunoproteasome in gli...

journal_title：Neuroreport

authors： Min L,Zeng X,Li B,Tao B,Shi J,Zhang W,Sun Q,Jing C,Wang X

更新日期：2019-10-16 00:00:00

abstract：:We injected neural tracers into the lateral funiculus of the spinal cord in order to relate the sites of origin of the spinal projections from the mesial cortical surface with the cytoarchitectonic organization of this region. We found a close correlation between the origin sites and density of corticospinal projectio...

journal_title：Neuroreport

authors： Luppino G,Matelli M,Camarda R,Rizzolatti G

更新日期：1994-12-20 00:00:00

abstract：:Paraoxonase polymorphisms have been associated with amyotrophic lateral sclerosis (ALS). Paraoxonases are detoxifying enzymes involved in the metabolism of organophosphates. We tested the hypothesis that genetic variation within paraoxonase genes would interact with the environmental exposure to paraoxonase substrates...

journal_title：Neuroreport

authors： Diekstra FP,Beleza-Meireles A,Leigh NP,Shaw CE,Al-Chalabi A

更新日期：2009-01-28 00:00:00

abstract：:Formalin fixation reduces beta-amyloid precursor protein (beta APP) immunoreactivity which restricts its study in archival tissue. Formic acid pretreatment has previously been used in an attempt to overcome this problem, but makes the sections very friable. In the present study, a microwave antigen retrieval method ha...

journal_title：Neuroreport

authors： Sherriff FE,Bridges LR,Jackson P

更新日期：1994-05-09 00:00:00

abstract：:Alpha oscillations during cognitive performance have mostly been studied in memory and/or basic attention tasks. This study investigates task-related alpha power desynchronization during an attentional switching task requiring higher executive attentional control. Low 8-10 Hz and high 10-12 Hz alpha power responses ar...

journal_title：Neuroreport

authors： Verstraeten E,Cluydts R

更新日期：2002-04-16 00:00:00

abstract：:Mammalian TIMELESS (TIM) was identified due to its sequence similarity to Drosophila TIM, an essential circadian clock protein in flies. Published literature is inconsistent regarding the rhythmic expression of mammalian Tim, the interaction of the TIM protein with other clock proteins and its role in regulating clock...

journal_title：Neuroreport

authors： Gotter AL

更新日期：2006-08-21 00:00:00

abstract：:A number of epidemiological studies suggest that estrogen therapy is linked to a reduced risk of developing Alzheimer's disease (AD). The present study was conducted to evaluate the effect of 17beta-estradiol on beta-amyloid (Abeta)-induced toxicity and was performed in rat pheochromocytoma PC 12 cells by measuring th...

journal_title：Neuroreport

authors： Svensson AL,Nordberg A

更新日期：1999-11-26 00:00:00

abstract：:The effects of high frequency repetitive transcranial magnetic stimulation on sensory perception and the pain tolerance thresholds were investigated applying both motor cortex stimulation and medial frontal cortex stimulation in normal study participants. Both the sensory perception and pain tolerance thresholds were ...

journal_title：Neuroreport

authors： Yoo WK,Kim YH,Doh WS,Lee JH,Jung KI,Park DS,Park ES

更新日期：2006-02-06 00:00:00