Nuclear triiodothyronine receptor expression is regulated by axon-Schwann cell contact.

Abstract:

:Thyroid hormones, which play an important role in the development and regeneration of the nervous system, require the presence of specific nuclear T3 receptors (NT3R). In this study we provide evidence that NT3R expression by Schwann cells was up-regulated in response to a loss of axonal contact in vitro and in vivo. In dorsal root ganglia explant cultures, Schwann cells which accompanied axons (nerve fibres) were devoid of NT3R. When Schwann cells were orphaned from axon contact by axon transection, all the nuclei of these cells displayed NT3R immunoreactivity. Similar results were obtained in situ; in adult rat sciatic nerve, Schwann cells which ensheathed healthy axons never expressed NT3R immunoreactivity. After sciatic nerve transection in vivo the nuclei of Schwann cells deprived of axonal contact displayed a clear NT3R immunoreaction.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Walter IB

doi

10.1097/00001756-199311180-00010

subject

Has Abstract

pub_date

1993-11-18 00:00:00

pages

137-40

issue

2

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

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