A ventral pontine pathway promotes rhythmic activity in the medulla of neonate mice.

Abstract:

:We have developed in new-born mice a ventral tilted-horizontal slice preparation for pontine stimulation and recording of spontaneous respiratory-like rhythmic trains of glutamatergic excitatory postsynaptic potentials (EPSPs) in medullary neurons. Electrical stimulations (10-50 Hz for 100-500 ms) of the caudal pontine reticular formation triggered a burst of EPSPs, recycling of the rhythmic activity and persistent increase of the rhythmic behaviour. These results identify a ventral pontine pathway that promotes rhythm generating mechanisms in the medulla and probably derives from a population of lateral reticular neurons identified in the embryonic hindbrain and eliminated after inactivation of the early developmental gene Krox-20.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Borday V,Kato F,Champagnat J

doi

10.1097/00001756-199712010-00005

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

3679-83

issue

17

eissn

0959-4965

issn

1473-558X

journal_volume

8

pub_type

杂志文章
  • Calbindin-D28K, parvalbumin and calretinin in primate lower motor neurons.

    abstract::It has been suggested that lower motor neurons containing calcium-binding proteins (CBP) may be resistant to degeneration in motor neuron disease. The testing of this hypothesis is hampered by lack of comprehensive information regarding the presence of CBPs in motor neurons. To address this shortcoming, we investigate...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200403010-00012

    authors: Fahandejsaadi A,Leung E,Rahaii R,Bu J,Geula C

    更新日期:2004-03-01 00:00:00

  • Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro.

    abstract::Factors controlling proliferation and differentiation are crucial in advancement of neural cell-based experimental neurodegenerative therapies. In this regard, nicotinamide has been shown to determine the fate of neural cells, enhance neuralization, and influence DNA repair and apoptosis. This study investigated wheth...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000071

    authors: Griffin SM,Pickard MR,Orme RP,Hawkins CP,Fricker RA

    更新日期:2013-12-18 00:00:00

  • Distinct anxiogenic/anxiolytic effects exerted by the hamster lateral amygdalar nucleus injected with ORX-A or ORX-B in the presence of a GABAergic agonist.

    abstract::Recently, there has been growing interest in the neurobiological role of some amygdalar neuromediators, such as GABA and orexins (ORX), that are responsible for stressful behaviors. Infusion of the major fear-related and panic-related basolateral amygdalar station, the lateral nucleus, with ORX-A and ORX-B, alone or i...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000213

    authors: Avolio E,Biasone A,Mele M,Alò R

    更新日期:2014-08-20 00:00:00

  • Disordered visual processing and oscillatory brain activity in autism and Williams syndrome.

    abstract::Two developmental disorders, autism and Williams syndrome, are both commonly described as having difficulties in integrating perceptual features, i.e. binding spatially separate elements into a whole. It is already known that healthy adults and infants display electroencephalographic (EEG) gamma-band bursts (around 40...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-200108280-00021

    authors: Grice SJ,Spratling MW,Karmiloff-Smith A,Halit H,Csibra G,de Haan M,Johnson MH

    更新日期:2001-08-28 00:00:00

  • Electrophysiological evidence for a two-stage process underlying single chord priming.

    abstract::In this study, we examine through electrophysiological measures three alternative mechanisms underlying musical chord priming: psychoacoustic distance, common parent-key, and distance along the circle of fifths. In contrast with previous behavioral studies, we present complex tones which do not blur the melodic compon...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32832bfcaf

    authors: Granot RY,Hai A

    更新日期:2009-06-17 00:00:00

  • Down regulation of nestin by TGF-beta or serum in SFME cells accompanies differentiation into astrocytes.

    abstract::The serum-free mouse embryo (SFME) cell line, derived from 16-day-old mouse embryos in medium in which serum was replaced by growth factors and other supplements, has been cultured for more than 200 generations. SFME cells are nontumorigenic, lack gross chromosomal abnormalities, and display characteristics of CNS pro...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199408150-00011

    authors: Loo DT,Althoen MC,Cotman CW

    更新日期:1994-08-15 00:00:00

  • Decreased neurofilament gene expression is an index of selective axonal hypotrophy in ageing.

    abstract::Axonal atrophy may reflect earlier and more reversible events in neurodegeneration and ageing than somatic atrophy. Innervation density by sympathetic fibres from the rat superior cervical ganglion (SCG) to the middle cerebral artery (MCA) decreases dramatically in old age, while that to the iris is largely unchanged....

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199702100-00044

    authors: Kuchel GA,Poon T,Irshad K,Richard C,Julien JP,Cowen T

    更新日期:1997-02-10 00:00:00

  • Auditory neural pathway evaluation on sensorineural hearing loss using diffusion tensor imaging.

    abstract::Diffusion tensor imaging is a new in vivo tool not only for the assessment of white matter structural integrity but also for diagnosis and assessment of disease conditions which disturb tissue structural coherence. In this study, we investigated the integrity of auditory pathway in patients of sensorineural hearing lo...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000134584.10207.1a

    authors: Chang Y,Lee SH,Lee YJ,Hwang MJ,Bae SJ,Kim MN,Lee J,Woo S,Lee H,Kang DS

    更新日期:2004-08-06 00:00:00

  • Increased startle responses in mice carrying mutations of glycine receptor subunit genes.

    abstract::An exaggerated startle response caused by mutations of the alpha 1 subunit gene of the inhibitory glycine receptor (GLRA1) is the key symptom of human hyperekplexia or startle disease. The recessive mouse mutant spasmodic (spd) carries a missense mutation in the corresponding murine Glra1 gene which reduces the affini...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199602290-00030

    authors: Koch M,Kling C,Becker CM

    更新日期:1996-02-29 00:00:00

  • Alzheimer's beta-amyloid peptide is conformationally modified by apolipoprotein E in vitro.

    abstract::Amyloid beta-peptide (A beta) is a major component of neuritic plaques, a feature of Alzheimer's disease (AD) brains. Recently, we showed that A beta adopts two major conformational states in solution, which differ in their abilities to form amyloid. These are highly amyloidogenic conformer (A beta ac) with a high con...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199602290-00010

    authors: Soto C,Golabek A,Wisniewski T,Castaño EM

    更新日期:1996-02-29 00:00:00

  • S100B protein stimulates calcineurin activity.

    abstract::S100B is a calcium binding protein from astrocytes that regulates protein phosphorylation by binding to substrates and protein kinases. S100B might also regulate protein phosphatases and this was investigated for protein phosphatase 2B (calcineurin). The results indicate that S100B (5-10 microM) increased the activity...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200402090-00021

    authors: Leal RB,Frizzo JK,Tramontina F,Fieuw-Makaroff S,Bobrovskaya L,Dunkley PR,Gonçalves CA

    更新日期:2004-02-09 00:00:00

  • Prostaglandin-D-synthase (beta-trace protein) levels in rat cerebrospinal fluid.

    abstract::The precise role of prostaglandin-D-synthase (beta-trace protein), the major constituent of cerebrospinal fluid, is unclear. In the present study, a sensitive and highly specific fluoroimmunoassay was developed. The measurement of the enzyme levels in rat CSF revealed a developmental change in the CSF levels with the ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199803300-00028

    authors: Kabeya K,Ishikawa K,Katakai K,Watanabe M,Ohe Y,Wakabayashi K,Mori M

    更新日期:1998-03-30 00:00:00

  • Grip force scaling after hemispatial neglect.

    abstract::Spatial neglect has been explained as an impairment in the representation of extrapersonal space. One account suggests that representations of extrapersonal space are spatially compressed following neglect. In support of this view it has been demonstrated that neglect patients systematically underestimate the size of ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199712010-00035

    authors: Shaw A,Jackson SR,Harvey M,Newport R,Krämer T,Dow L

    更新日期:1997-12-01 00:00:00

  • Neurometabolite changes in patients with complex regional pain syndrome using magnetic resonance spectroscopy: a pilot study.

    abstract::The aim of this study was to investigate distinct neurometabolites in the right and left thalamus and insula of patients with complex regional pain syndrome (CRPS) compared with healthy controls using proton magnetic resonance spectroscopy. Levels of N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG), myo-inosi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001168

    authors: Jung YH,Kim H,Jeon SY,Kwon JM,Kim YC,Lee WJ,Lee D,Lee JY,Moon JY,Kang DH

    更新日期:2019-01-16 00:00:00

  • Neuroactive steroids modulate GABA inhibition of hypothalamic somatostatin release.

    abstract::The reduced steroids 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and 3 alpha,21-di-hydroxy-5 alpha-pregnan-20-one (allotetrahydroDOC) are potent ligands of GABAA receptors. This study examined the possible modulatory effect of these metabolites on GABA inhibition of somatostatin release in cultured hypot...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199510020-00025

    authors: Tapia-Arancibia L,André M,Belmar J,Arancibia S

    更新日期:1995-10-02 00:00:00

  • Microglial activation in multiple system atrophy: a potential role for NF-kappaB/rel proteins.

    abstract::Microglial activation is a prominent feature of affected brain areas in multiple system atrophy. Microglia express proinflammatory peptides, which may be a result of activation of nuclear factor-KB. We investigated the nuclear presence of RelA, the 65 kDa subunit of the NF-KB/RelA family in striatum and brain stem of ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199809140-00020

    authors: Schwarz SC,Seufferlein T,Liptay S,Schmid RM,Kasischke K,Foster OJ,Daniel S,Schwarz J

    更新日期:1998-09-14 00:00:00

  • Time-dependent effect of transcranial direct current stimulation on the enhancement of working memory.

    abstract::The time-dependent effect of transcranial direct current stimulation (tDCS) on working memory was investigated by applying anodal stimulation over the left prefrontal cortex. This single-blind, sham-controlled crossover study recruited 15 healthy participants. A three-back verbal working-memory task was performed befo...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/WNR.0b013e3282f2adfd

    authors: Ohn SH,Park CI,Yoo WK,Ko MH,Choi KP,Kim GM,Lee YT,Kim YH

    更新日期:2008-01-08 00:00:00

  • Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex.

    abstract::When a food is eaten to satiety, its reward value decreases. This decrease is usually greater for the food eaten to satiety than for other foods, an effect termed sensory-specific satiety. In an fMRI investigation it was shown that for a region of the orbitofrontal cortex the activation produced by the odour of the fo...

    journal_title:Neuroreport

    pub_type: 更正并重新发布的文章,杂志文章

    doi:10.1097/00001756-200003200-00046

    authors: O'Doherty J,Rolls ET,Francis S,Bowtell R,McGlone F,Kobal G,Renner B,Ahne G

    更新日期:2000-03-20 00:00:00

  • Counter-stimulatory effects on pain perception and processing are significantly altered by attention: an fMRI study.

    abstract::Counter-stimulation reduces pain perception; however, the role of attention during this process is rarely discussed despite attention itself being a well known modulator of pain perception. This study investigated the effect of attentional modulation on pain perception during counter-stimulation using fMRI. Subjects r...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200107030-00047

    authors: Longe SE,Wise R,Bantick S,Lloyd D,Johansen-Berg H,McGlone F,Tracey I

    更新日期:2001-07-03 00:00:00

  • Nocistatin, a peptide reversing acute and chronic morphine tolerance.

    abstract::It has been reported that intracerebroventricular (i.c.v.) injection of nociception/orphanin FQ (OFQ) can antagonize morphine analgesia, whereas i.c.v. OFQ antibody can reverse morphine tolerance. Nocistatin (NST) is a recently characterized neuropeptide possessing an antagonizing effect on OFQ. Here we examine whethe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200106130-00054

    authors: Sun RQ,Zhao CS,Wang HJ,Jing Z,Wang W,Yang K,Wang Y,Chang JK,Han JS

    更新日期:2001-06-13 00:00:00

  • Detection of verbal discordances during sleep.

    abstract::We used an electrophysiological marker of linguistic discordance, the N400 wave, to investigate how linguistic and pseudo-linguistic stimuli are categorised during sleep as compared to waking. During wakefulness, signs of discordance detection were, as expected, greater for pseudo-words than for real but semantically ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200207190-00026

    authors: Perrin F,Bastuji H,Garcia-Larrea L

    更新日期:2002-07-19 00:00:00

  • Is there a link between sleep changes and memory in Alzheimer's disease?

    abstract::Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD pa...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32830867c4

    authors: Rauchs G,Schabus M,Parapatics S,Bertran F,Clochon P,Hot P,Denise P,Desgranges B,Eustache F,Gruber G,Anderer P

    更新日期:2008-07-16 00:00:00

  • The AMPA antagonist, NBQX, protects against ischemia-induced loss of cerebellar Purkinje cells.

    abstract::We examined the effect of an AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole) antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo (F) quinoxaline (NBQX), on rat cerebellar Purkinje cell loss and hippocampal pyramidal CA1 cell loss, after 10 minutes of global cerebral ischemia. NBQX was given intraperitoneally in a do...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199209000-00016

    authors: Balchen T,Diemer NH

    更新日期:1992-09-01 00:00:00

  • Responses from new receptive fields of VPL neurones following deafferentation.

    abstract::Single unit recordings were made from the ventral posterior lateral thalamus of anaesthetized rats to characterize responses to the activation of new receptive fields induced by either local anaesthesia or amputation. Receptive fields confined to single digits were identified and evoked unit responses to the stimulati...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Shin HC,Park S,Son J,Sohn JH

    更新日期:1995-12-29 00:00:00

  • Serum immunoglobulins in brain tumours and lumbar disc diseases.

    abstract::Changes of serum immunoglobulin (Ig) concentrations may occur in both brain tumours and lumbar disc diseases (LDD). The purpose of this study was to investigate the changes of pre- and post-operative serum Ig levels in brain tumours and LDDs. Serum IgG, IgA and IgM levels were measured in 127 patients with brain tumou...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-200002070-00011

    authors: Yüceer N,Arasil E,Temiz C

    更新日期:2000-02-07 00:00:00

  • Mutational characterization of ATP7B gene in 103 Wilson's disease patients from Southern China: identification of three novel mutations.

    abstract::Wilson's disease (WD) is an autosomal recessive inheritance disorder of copper metabolism due to mutations in the ATP7B gene. The distribution of ATP7B gene mutations is diverse in different population. This study aimed to examine the genotypes of the ATP7B mutant alleles in WD patients from Southern China. Genomic DN...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000216

    authors: Wei Z,Huang Y,Liu A,Diao S,Yu Q,Peng Z,Hong M

    更新日期:2014-10-01 00:00:00

  • Transient expression of PKC gamma mRNA in cerebellar granule cells during rat brain development.

    abstract::The localization of PKC gamma mRNA expression during the maturation of rat cerebellum has been studied by in situ hybridization. We found a transient expression over the granule cell layer and persistent high expression in the Purkinje cells during postnatal development. Expression in granule cells appeared as early a...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199307000-00015

    authors: Herms J,Zurmöhle U,Schlingensiepen KH,Brysch W

    更新日期:1993-07-01 00:00:00

  • Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice.

    abstract::Dysfunction of the cholinergic system of the basal forebrain complex is one of the major contributors toward cognitive impairment in Alzheimer's disease (AD). In AD, degeneration of cholinergic fibers that project to the cerebral cortex and hippocampus may be attributed to the development of neurofibrillary tangles (N...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000423

    authors: Kim JM,Kim SS,Lee YD

    更新日期:2015-09-09 00:00:00

  • Recruitment of the middle temporal area by tactile motion in congenital blindness.

    abstract::We used positron emission tomography to investigate whether tactile motion discrimination activates the dorsal visual stream in congenitally blind (CB) participants compared with sighted controls. The tactile stimuli consisted of either static dots, dots moving coherently in one of two possible directions, or in rando...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283279909

    authors: Ptito M,Matteau I,Gjedde A,Kupers R

    更新日期:2009-04-22 00:00:00

  • Adenovirus-mediated gene transfer of basic fibroblast growth factor promotes the survival of primary-cultured rat neuronal cells.

    abstract::We constructed two replication-deficient recombinant adenovirus vectors coding human basic fibroblast growth factor (bFGF), one with and one without the interleukin-2 (IL-2) secretory signal sequence and examined their neurotrophic effects on primary neuronal cells in vitro. The primary neuronal cells were successfull...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200006260-00039

    authors: Matsuoka N,Miyatake S,Yukawa H,Takahashi JC,Saiki M,Mori H,Ishii K,Akimoto M,Hamada H,Hashimoto N

    更新日期:2000-06-26 00:00:00