Abstract:
:We have developed in new-born mice a ventral tilted-horizontal slice preparation for pontine stimulation and recording of spontaneous respiratory-like rhythmic trains of glutamatergic excitatory postsynaptic potentials (EPSPs) in medullary neurons. Electrical stimulations (10-50 Hz for 100-500 ms) of the caudal pontine reticular formation triggered a burst of EPSPs, recycling of the rhythmic activity and persistent increase of the rhythmic behaviour. These results identify a ventral pontine pathway that promotes rhythm generating mechanisms in the medulla and probably derives from a population of lateral reticular neurons identified in the embryonic hindbrain and eliminated after inactivation of the early developmental gene Krox-20.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Borday V,Kato F,Champagnat Jdoi
10.1097/00001756-199712010-00005subject
Has Abstractpub_date
1997-12-01 00:00:00pages
3679-83issue
17eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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