Abstract:
:Using immunohistochemistry, we investigated in the cat the effects of MPTP, a Parkinsonian syndrome-inducing substance, on brain type B monoamine oxidase (MAO-B) which is responsible for the conversion of MPTP to its neurotoxic product (MPP+). Intraperitoneal administration of MPTP (5 mg kg-1 daily for 5 days) caused a selective suppression of MAO-B in neurones of the raphe nuclei without affecting hypothalamic MAO-B. Since these effects were accompanied by loss of nigral dopaminergic cells but not of raphe cell bodies or 5-HT immunoreactivity, we suggest that MPTP suppresses raphe MAO-B without destroying its presumed host serotoninergic neurones and that raphe MAO-B does not appear to be crucial in the MPTP-induced nigral lesion. In addition, the MPTP-induced paradoxical sleep suppression might be related to this raphe MAO-B loss.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Lin JS,Hou Y,Kitahama K,Jouvet Mdoi
10.1097/00001756-199501000-00024subject
Has Abstractpub_date
1995-01-26 00:00:00pages
321-4issue
2eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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