Abstract:
:The 6-hydroxydopamine rat model of Parkinson's disease was combined with intracerebral drug infusions to examine the influence of glutamate receptors on striatal output activity. When infused into the dopamine-denervated striatum, the AMPA-kainate receptor antagonist DNQX dose-dependently elicited contralateral rotation and ipsilateral Fos immunoreactivity (Fos-IR) in the globus pallidus, a target nucleus of striatal output. DNQX did not elicit rotation or Fos-IR in unlesioned or partially lesioned rats. In addition, the NMDA receptor antagonist AP-5 failed to induce rotation and had minimal effects on pallidal Fos-IR in lesioned rats. These results suggest a role for striatal AMPA-kainate receptors in the pathology and treatment of Parkinson's disease.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Schuller JJ,Marshall JFdoi
10.1097/00001756-199512150-00034subject
Has Abstractpub_date
1995-12-15 00:00:00pages
2594-8issue
18eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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