Abstract:
:Apolipoprotein E (apoE) and the beta-amyloid peptide are both found in the senile plaques associated with Alzheimer's disease. Several studies have recently determined that apoE can prevent beta-amyloid fibril (Abetaf) formation in vitro. In vivo, apoE is normally associated with a lipid source. We show that both recombinant and purified plasma apoE inhibit Abetaf formation in a dose-dependent manner. The three major apoE isoforms were equipotent at inhibiting Abetaf formation. ApoE associated with either cholesterol-containing liposomes or very low density lipoproteins displayed less potent inhibition of Abetaf formation than their unlipidated counterparts. These results indicate that the presence of associated lipids reduce the ability of apoE to inhibit the formation of Abetaf in vitro.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Beffert U,Poirier Jdoi
10.1097/00001756-199810050-00031subject
Has Abstractpub_date
1998-10-05 00:00:00pages
3321-3issue
14eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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