Human area 5 modulates corticospinal output during movement preparation.

Abstract:

:Neuroimaging evidence suggests that human Brodmann area 5 (BA5) within the superior parietal lobule contributes to movement planning. However, a causal role for the contribution of BA5 to preparatory processes has yet to be reported. We used paired-pulse transcranial magnetic stimulation to investigate the influence of human BA5 on corticospinal excitability during movement preparation in the context of a GO/NO-GO task. Functional connectivity between BA5 and the ipsilateral primary motor cortex (M1) was investigated by probing corticospinal output to the first dorsal interosseous muscle of the right hand. Results indicate that BA5 influences M1 during movement preparation in a task-specific manner: motor-evoked potentials are suppressed in the context of a NO-GO versus GO task. These findings provide evidence that human BA5 participates in movement preparation and differentiates between whether a movement is withheld or executed.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Mackenzie TN,Bailey AZ,Mi PY,Tsang P,Jones CB,Nelson AJ

doi

10.1097/WNR.0000000000000655

subject

Has Abstract

pub_date

2016-09-28 00:00:00

pages

1056-60

issue

14

eissn

0959-4965

issn

1473-558X

journal_volume

27

pub_type

杂志文章
  • Modulation of striatal aspartate and dynorphin B release by cholecystokinin (CCK-8) studied in vivo with microdialysis.

    abstract::Sulphated cholecystokinin-8 (CCK-8) given into the neostriatum of the rat by in vivo microdialysis produced a concentration-dependent (1-100 microM) increase in extracellular aspartate (Asp) and dynorphin B (Dyn B), but not in glutamate, GABA or dopamine levels. The increase in Asp levels produced by 10 microM CCK-8 w...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199411000-00024

    authors: You ZB,Pettersson E,Herrera-Marschitz M,Hökfelt T,Terenius L,Nylander I,Goiny M,Hughes J,O'Connor WT,Ungerstedt U

    更新日期:1994-11-21 00:00:00

  • Maternal behavior: activation of the central oxytocin receptor system in parturient rats?

    abstract::Parturition plays a critical role in the full expression of maternal behavior in postpartum females, yet the precise mechanism remains unclear. Here we examined the role of parturition in the activation of Fos and FosB in the central oxytocin receptor (OTR) system in rats. Although expression of FosB, not Fos, was see...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200308060-00007

    authors: Lin SH,Kiyohara T,Sun B

    更新日期:2003-08-06 00:00:00

  • Dissociation of inhibition from error processing using a parametric inhibitory task during functional magnetic resonance imaging.

    abstract::Inhibition, the process that overrides and reverses the execution of a thought, action, or emotion, is important in daily life. Sixteen healthy volunteers performed a parametrically modulated motor inhibition task during functional magnetic resonance imaging. Two results were observed: (1) increased error-related ante...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200505120-00020

    authors: Matthews SC,Simmons AN,Arce E,Paulus MP

    更新日期:2005-05-12 00:00:00

  • Cerebral organization in bilinguals: a PET study of Chinese-English verb generation.

    abstract::Positron emission tomography (PET) was used to investigate cerebral organization in seven subjects who had Mandarin Chinese as their native language (L1), and learned English (L2) later in life. When activation from word repetition was subtracted from verb generation in L1 and L2, CBF increases were observed for both ...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199909090-00026

    authors: Klein D,Milner B,Zatorre RJ,Zhao V,Nikelski J

    更新日期:1999-09-09 00:00:00

  • Visually-triggered oscillations in the cat lateral posterior-pulvinar complex.

    abstract::The so-called 40 Hz oscillations are found at almost all stages of visual processing are thought to play a critical role in perception. The goal of this investigation was to look at the presence of stimulus-specific oscillations in the lateral posterior-pulvinar complex of the thalampus (LP-P) for which the oscillatio...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199511270-00017

    authors: Shumikhina S,Molotchnikoff S

    更新日期:1995-11-27 00:00:00

  • BoNT/E prevents seizure-induced activation of caspase 3 in the rat hippocampus.

    abstract::Clinical and experimental studies clearly demonstrate that prolonged seizures and status epilepticus induce neuronal cell death in the brain. Recent evidence suggests that induction of apoptosis contributes greatly to seizure-induced brain damage. We recently demonstrated that intrahippocampal delivery of botulinum ne...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32801b3cbb

    authors: Manno I,Antonucci F,Caleo M,Bozzi Y

    更新日期:2007-04-16 00:00:00

  • Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.

    abstract::Recently it has been reported that a missense G(88)C mutation within exon 3 and a missense G(209)A mutation within exon 4 of the alpha-synuclein gene were linked to familial Parkinson's Disease (PD). We decided to investigate if these and any other mutations in exons 3 and 4 of the alpha-synuclein gene could be detect...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199812010-00029

    authors: El-Agnaf OM,Curran MD,Wallace A,Middleton D,Murgatroyd C,Curtis A,Perry R,Jaros E

    更新日期:1998-12-01 00:00:00

  • Continuous theta-burst stimulation over the primary somatosensory cortex modulates interhemispheric inhibition.

    abstract::One mechanism thought to mediate hand and upper limb control across motor cortices is called interhemispheric inhibition (IHI). Somatosensory cortices are important in the motor control of the hand, although the neural mechanisms by which somatic loci act are not fully understood. In the present study, we study the po...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32836131ca

    authors: Zapallow CM,Jacobs MF,Lee KG,Asmussen MJ,Tsang P,Nelson AJ

    更新日期:2013-05-08 00:00:00

  • Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures.

    abstract::The neuroprotective effect of docosahexaenoic acid (DHA) on the glutamate-induced cytotoxicity in rat hippocampal cultures was investigated in the present study. DHA at 5-50 microg/ml successfully protected neurons against the cytotoxicity, markedly increased the cell viability, inhibited both nitric oxide (NO) produc...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200312190-00033

    authors: Wang X,Zhao X,Mao ZY,Wang XM,Liu ZL

    更新日期:2003-12-19 00:00:00

  • Injury selectively down-regulates the gene encoding for the Id4 transcription factor in primary cultures of forebrain astrocytes.

    abstract::Astrogliosis is an important component of the response to injury of the central nervous system (CNS). The Id family of helix-loop-helix (HLH) transcription factors has been implicated in the regulation of cellular differentiation in several different lineages and may contribute to the regulation of astrogliosis. We ex...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199812210-00013

    authors: Andres-Barquin PJ,Hernandez MC,Israel MA

    更新日期:1998-12-21 00:00:00

  • IL-6 up-regulates CNTF mRNA expression and enhances neurite regeneration.

    abstract::Interleukin-6 (IL-6) is a neurotrophic cytokine, however, its direct effect on nerve regeneration has not been well characterized. We therefore examined the effect of IL-6 on neurite regeneration using the rat dorsal root ganglion. IL-6 significantly enhanced neurite regeneration from transected nerve terminals. We al...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200104170-00043

    authors: Shuto T,Horie H,Hikawa N,Sango K,Tokashiki A,Murata H,Yamamoto I,Ishikawa Y

    更新日期:2001-04-17 00:00:00

  • Ontogeny of two different benzodiazepine binding sites in the chick optic lobe.

    abstract::The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I represented only a minor proportion (1.77%). During development there w...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199510010-00015

    authors: Gravielle MC,de Plazas SF

    更新日期:1995-10-23 00:00:00

  • Double-pulse stimulation dissociates intrathalamic and cortical high-frequency (>400Hz) SEP components in man.

    abstract::Human somatosensory evoked potentials (SEP) contain high-frequency (600 Hz) wavelet bursts possibly reflecting repetitive population spikes in thalamocortical axons and/or postsynaptic responses. To dissociate thalamic and cortical burst components the recovery of intrathalamic SEP (derived from electrodes implanted f...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-200004270-00030

    authors: Klostermann F,Funk T,Vesper J,Siedenberg R,Curio G

    更新日期:2000-04-27 00:00:00

  • Semantic acquisition without memories: evidence from transient global amnesia.

    abstract::Transient global amnesia (TGA), characterised by a profound anterograde amnesia, is a model of interest to study the acquisition of novel meanings independent of episodic functioning. Three patients were tested during a TGA attack, two in the early recovery phase and the third during the acute phase of TGA, with a sem...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200112040-00052

    authors: Guillery B,Desgranges B,Katis S,de la Sayette V,Viader F,Eustache F

    更新日期:2001-12-04 00:00:00

  • Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice.

    abstract::Kisspeptin is distributed not only in brain areas for regulating reproduction but also in nuclei involved in feeding control. Whether kisspeptin alters food intake is unknown in mice. We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring. Kisspeptin...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32834558df

    authors: Stengel A,Wang L,Goebel-Stengel M,Taché Y

    更新日期:2011-03-30 00:00:00

  • IL-10 down-regulates human microglial IL-8 by inhibition of NF-kappaB activation.

    abstract::In the present study, we tested the hypothesis that interleukin (IL)-10 down-regulates human microglial cell IL-8 release by inhibiting activation of nuclear factor kappa B (NF-kappaB). Immunohistochemical staining demonstrated that IL-10 markedly suppressed lipopolysaccharide (LPS)- and IL-1beta-stimulated IL-8 expre...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199806010-00010

    authors: Ehrlich LC,Hu S,Peterson PK,Chao CC

    更新日期:1998-06-01 00:00:00

  • Neural correlates of the modified Stroop effect in post-traumatic stress disorder: an event-related potential study.

    abstract::Previous studies have provided electrophysiological evidence for attentional abnormalities in patients with post-traumatic stress disorder (PTSD). The present study examined the electrophysiological activity of trauma-exposed patients with or without a PTSD during a modified Stroop task. The PTSD group showed a reduce...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32835a989e

    authors: Chen X,Wei D,Dupuis-Roy N,Du X,Qiu J,Zhang Q

    更新日期:2012-12-19 00:00:00

  • Polarization of the human motor cortex through the scalp.

    abstract::Direct currents (DC) applied directly to central nervous system structures produce substantial and long-lasting effects in animal experiments. We tested the functional effects of very weak scalp DC (< 0.5 mA, 7 s) on the human motor cortex by assessing the changes in motor potentials evoked by transcranial magnetic br...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199807130-00020

    authors: Priori A,Berardelli A,Rona S,Accornero N,Manfredi M

    更新日期:1998-07-13 00:00:00

  • A suprachiasmatic nucleus projecting retinal ganglion cell exhibits an unusually large dendritic field in the hamster.

    abstract::The majority of retinal ganglion cells innervating the suprachiasmatic nucleus are intrinsically light sensitive, while the rest are conventional ganglion cells that collect inputs through conventional photoreceptors. Here we report a rarely encountered ganglion cell that had a dendritic field covering approximately 1...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000234757.26610.e8

    authors: Pu M,Chen B,Li RS,Tay D,So KF

    更新日期:2006-10-02 00:00:00

  • Human CNTF and related cytokines: effects on DRG neurone survival.

    abstract::Ciliary neurotrophic factor (CNTF), leukaemia inhibitory factor (LIF), oncostatin M (OSM), interleukin-6 (IL-6), and interleukin-11 (IL-11) are structurally and functionally related cytokines. We compared their survival-promoting activities on embryonic chick and newborn rat dorsal root ganglion (DRG) neurones. Human ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Simon R,Thier M,Krüttgen A,Rose-John S,Weiergräber O,Heinrich PC,Schröder JM,Weis J

    更新日期:1995-12-29 00:00:00

  • ACTH in the pigeon vestibular ganglion.

    abstract::Adrenocorticotropic hormone (ACTH) is a member of the opiocortin family of peptides. Within the central nervous system, ACTH-synthesizing neurons are generally considered to be located within the hypothalamus and are known to be involved in the neural circuitry underlying the integration of stress responses. We now re...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199202000-00001

    authors: Güntürkün O,Deviche P

    更新日期:1992-02-01 00:00:00

  • Mouse hippocampo-prefrontal paired-pulse facilitation and long-term potentiation in vivo.

    abstract::To confirm neural plasticity of the mouse hippocampo-prefrontal cortex (PFC) pathway, paired-pulse facilitation (PPF) and long-term potentiation (LTP) induction were determined in the pathway. In addition, we tested whether the plasticity differs in projections of the pathway from the dorsal (upper) and ventral (lower...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200105080-00028

    authors: Izaki Y,Takita M,Nomura M

    更新日期:2001-05-08 00:00:00

  • Incomplete regression of multiple climbing fibre innervation of cerebellar Purkinje cells in mGLuR1 mutant mice.

    abstract::Recent reports have suggested the existence of a causal relationship between impaired regression of multiple climbing fibre innervation and impaired motor coordination in protein kinase C gamma subunit (PKC gamma) mutant mice. In the present patch-clamp study, performed in thin cerebellar slices prepared from adult mu...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199701200-00038

    authors: Levenes C,Daniel H,Jaillard D,Conquet F,Crépel F

    更新日期:1997-01-20 00:00:00

  • Calcium-mediated neuronal degeneration following singlet oxygen production.

    abstract::NONINVASIVE photolytic injury to targeted neuronal subpopulations in vivo causes unique, slowly progressive neuronal degeneration. To examine the mechanisms of degeneration toward development and transplantation studies, cytosolic calcium levels were measured in vitro from neocortical neurons after incorporation of ph...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199208000-00014

    authors: Sheen VL,Dreyer EB,Macklis JD

    更新日期:1992-08-01 00:00:00

  • Withdrawal from a single exposure to cocaine increases 5-HT2A receptor and G protein function.

    abstract::We previously reported that withdrawal from chronic cocaine produces supersensitivity of serotonin 2A receptors. We report here the minimum cocaine exposure necessary to produce withdrawal-associated increases in serotonin 2A receptor signaling in the frontal cortex. Rats withdrawn from cocaine treatments of 1, 3 or 7...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000246324.43567.55

    authors: Carrasco GA,Battaglia G

    更新日期:2007-01-08 00:00:00

  • The AMPA antagonist, NBQX, protects against ischemia-induced loss of cerebellar Purkinje cells.

    abstract::We examined the effect of an AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole) antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo (F) quinoxaline (NBQX), on rat cerebellar Purkinje cell loss and hippocampal pyramidal CA1 cell loss, after 10 minutes of global cerebral ischemia. NBQX was given intraperitoneally in a do...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199209000-00016

    authors: Balchen T,Diemer NH

    更新日期:1992-09-01 00:00:00

  • Cortical evoked potentials due to motion contrast in the blind hemifield.

    abstract::Subcortical visual inputs to motion-selective cortex in primates survive after damage to the primary visual cortex (area 17/V1). Activation of human motion cortex was examined using scalp electrodes in a V1-damaged hemianope. Blind field motion-onset visual evoked potentials (VEPs) shared many of the characteristics a...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199911260-00024

    authors: Benson PJ,Guo K,Hardiman MJ

    更新日期:1999-11-26 00:00:00

  • Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues.

    abstract::Expression of monocarboxylate transporter MCT1 was studied in archival tissues from human CNS using antibodies to the carboxyl-terminal end of MCT1. Sections of neocortex, hippocampus and cerebellum of brains from 10 adult autopsy patients who died from other than CNS disease, and from archival surgical biopsy specime...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200103260-00030

    authors: Froberg MK,Gerhart DZ,Enerson BE,Manivel C,Guzman-Paz M,Seacotte N,Drewes LR

    更新日期:2001-03-26 00:00:00

  • Cognitive bias induced by visuo-motor adaptation to prisms: a simulation of unilateral neglect in normal individuals?

    abstract::Unilateral neglect has been recently shown to be improved following a short period of adaptation to wedge prisms. The present study investigates whether visuo-motor adaptation can generate a bias in normals on line bisection tasks classically used to assess unilateral neglect. Our results show that adaptation to left-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200006260-00019

    authors: Colent C,Pisella L,Bernieri C,Rode G,Rossetti Y

    更新日期:2000-06-26 00:00:00

  • LTD and LTP induced by transcranial magnetic stimulation in auditory cortex.

    abstract::Using a system capable of relatively localized and rapidrate transcranial magnetic stimulation (rTMS), evoked trains of complex spikes were studied in rodent auditory cortex. Low rate rTMS from 1 to 10Hz produced a frequency-dependent increase in spike rate. Iterations of rTMS resulted in long-term potentiation (LTP)-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199601310-00035

    authors: Wang H,Wang X,Scheich H

    更新日期:1996-01-31 00:00:00