Abstract:
:Kisspeptin is distributed not only in brain areas for regulating reproduction but also in nuclei involved in feeding control. Whether kisspeptin alters food intake is unknown in mice. We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring. Kisspeptin-10 (0.3, 1, and 3 μg/mouse) dose-dependently inhibited the feeding response to an overnight fast by 50, 95, and 90% respectively, during the 2-3 h period postinjection. The 1μg/mouse dose reduced the 4-h cumulative food intake by 28% whereas intraperitoneal injection (10 μg/mouse) did not. The decreased 4-h food intake was due to reduced meal frequency (-45%/4 h), whereas meal size and gastric emptying were not altered. These data suggest that kisspeptin may be a negative central regulator of feeding by increasing satiety.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Stengel A,Wang L,Goebel-Stengel M,Taché Ydoi
10.1097/WNR.0b013e32834558dfsubject
Has Abstractpub_date
2011-03-30 00:00:00pages
253-7issue
5eissn
0959-4965issn
1473-558Xpii
00001756-201103300-00012journal_volume
22pub_type
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