Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures.

abstract：:We investigated the role of kainate receptor activation in modulating the influx of Ca2+ coupled to the exocytotic release of glutamate in rat hippocampal synaptosomal fractions (P2). In whole hippocampus synaptosomes stimulation with domoic acid increased the intracellular free Ca2+ concentration ([Ca2+]i) in a dose-...

journal_title：Neuroreport

authors： Malva JO,Carvalho AP,Carvalho CM

更新日期：1996-05-17 00:00:00

abstract：:The ATP-gated cation channel P2X3 is expressed selectively by rat sensory neurones, and may play a role in nociception by binding ATP released from damaged or inflamed tissues. However, the distribution of this channel in human sensory neurons is not known. Using a specific antibody, we have demonstrated intense P2X3 ...

journal_title：Neuroreport

authors： Yiangou Y,Facer P,Birch R,Sangameswaran L,Eglen R,Anand P

更新日期：2000-04-07 00:00:00

abstract：:Other-race faces are less accurately recognized than same race faces but classified faster by race. Using event-related potentials (ERPs), we captured the brain temporal dynamics of face classification by race processing performed by 12 Caucasian participants. As expected, participants were faster to classify by race ...

journal_title：Neuroreport

authors： Caldara R,Rossion B,Bovet P,Hauert CA

更新日期：2004-04-09 00:00:00

abstract：:Recent studies have discussed the role of the cerebellum in not only motor but also cognitive functions, and in particular, fronto-executive operations. Similar to a previous study on hemineglect patients, we recorded eye movements during a visual search task to investigate patients with isolated infarction of the cer...

journal_title：Neuroreport

authors： Machner B,Sprenger A,Kömpf D,Heide W

更新日期：2005-09-08 00:00:00

abstract：:The effect of systemic treatment with 1-aminocyclopro-panecarboxylic acid (ACPC), a partial agonist at the glycine site of the NMDA receptor, on convulsions and neurodegeneration induced by intrahippocampal injection of NMDA was investigated in mice. Five days after intrahippocampal NMDA infusion, 80-100% pyramidal ce...

journal_title：Neuroreport

authors： Zapata A,Capdevila JL,Viu E,Trullas R

更新日期：1996-01-31 00:00:00

abstract：:The death of spinal motoneurones after axotomy provides a useful model for studying novel factors which prevent motoneurone loss in vivo. Peripheral nerves of newborn rats were unilaterally transected and treated with either a vehicle solution or leukaemia inhibitory factor (LIF). Compared with the vehicle controls, t...

journal_title：Neuroreport

authors： Cheema SS,Richards LJ,Murphy M,Bartlett PF

更新日期：1994-04-14 00:00:00

abstract：:To achieve neuronal differentiation of mouse bone mesenchymal stem cells (bMSCs) into neuron-like cells and explore the role of miR-122-5p that may regulate T-box brain 1 (Tbr1) expression during the induction. BMSCs were cultured and induced with butylated hydroxyanisole, retinoic acid (RA), basic fibroblast growth f...

journal_title：Neuroreport

authors： Yang Y,Shen Z,Sun W,Gao S,Li Y,Guo Y

更新日期：2017-05-03 00:00:00

abstract：:Retinal gamma-aminobutyric acid type C (GABA[C]) receptors are believed to consist of rho subunits. The pharmacological properties of GABA(C) receptors appear to vary among different species. Since the mouse is an important model for gene targeting and behavioral studies, this study was aimed at cloning rho subunits i...

journal_title：Neuroreport

authors： Greka A,Koolen JA,Lipton SA,Zhang D

更新日期：1998-01-26 00:00:00

abstract：:Using reverse transcription-polymerase chain reaction and in situ hybridization, we investigated the expression and cellular localization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in the rat retina following optic nerve transection (ONT). Following ONT, a signal for CNTFRalpha mRNA appeared in a layer...

journal_title：Neuroreport

authors： Ju WK,Kim KY,Lee MY,Hofmann HD,Kirsch M,Cha JH,Oh SJ,Chun MH

更新日期：2000-11-27 00:00:00

abstract：:We examined the effect of an AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole) antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo (F) quinoxaline (NBQX), on rat cerebellar Purkinje cell loss and hippocampal pyramidal CA1 cell loss, after 10 minutes of global cerebral ischemia. NBQX was given intraperitoneally in a do...

journal_title：Neuroreport

authors： Balchen T,Diemer NH

更新日期：1992-09-01 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenolic extract in green tea and it has attracted increasing attention for its multiple bioactive effects. However, the mechanisms by which EGCG exerts its neuroprotective actions in Alzheimer's disease (AD) are presently lacking. In the present study, a ...

journal_title：Neuroreport

authors： Guo Y,Zhao Y,Nan Y,Wang X,Chen Y,Wang S

更新日期：2017-07-05 00:00:00

abstract：:The effects of intracerebroventricular (i.c.v.) administration of galanin on plasma growth hormone (GH) concentrations and its possible mechanism of action have been examined in sheep. Galanin administration icv resulted in a dose-dependent increase in plasma GH concentrations (p < 0.01). Concurrent administration of ...

journal_title：Neuroreport

authors： Spencer GS,Berry CJ,Bass JJ

更新日期：1994-01-12 00:00:00

abstract：:Prepulse inhibition (PPI) of the acoustic startle reflex is a measure of sensorimotor gating which occurs in both rodents and humans. PPI is deficient in severe neuropsychiatric disorders such as schizophrenia. We investigated PPI in 10 adult monkeys (Cebus apella). Stimuli were 115 dB white noise startle pulses, eith...

journal_title：Neuroreport

authors： Linn GS,Javitt DC

更新日期：2001-01-22 00:00:00

abstract：OBJECTIVE:Birdsong sounds are often used to inform visually-challenged people about the presence of basic infrastructures, and therefore need to be salient in noisy urban environments. How salient sounds are processed in the brain could inform us about the optimal birdsong in such environments. However, brain activity ...

journal_title：Neuroreport

authors： Yano H,Soeta Y

更新日期：2021-01-13 00:00:00

abstract：:ErbBs are a family of receptors involved in the trophic maintenance of Schwann cells. Little is known about their expression changes during peripheral nerve regeneration. The aim of this study was thus to investigate variations in ErbBs after end-to-end and end-to-side nerve regeneration in the rat median nerve model....

journal_title：Neuroreport

authors： Audisio C,Nicolino S,Scevola A,Tos P,Geuna S,Battiston B,Perroteau I

更新日期：2008-10-29 00:00:00

abstract：:We used multiple-labelling immunofluorescence, intracellular dye injection, electrophysiological recording and confocal microscopy to examine the expression of immunoreactivity to protein kinase C (PKC) and protein kinase A (PKA) in sympathetic ganglia of guinea-pigs. PKCalpha and PKCgamma were widespread in vasoconst...

journal_title：Neuroreport

authors： Gibbins IL,Matthew SE,Jobling P

更新日期：1999-04-06 00:00:00

abstract：:Exosomes derived from Schwann cells have been known to have a variety of functions in the development and repair of the peripheral nervous system, and cyclic AMP (cAMP) is a key inducer of Schwann cell differentiation. In the present study, we aimed to study the effect of exosomes derived from differentiated Schwann c...

journal_title：Neuroreport

authors： Sohn EJ,Park HT,Shin YK

更新日期：2020-05-07 00:00:00

abstract：:Addition of the beta-hydroxy-beta-methylglutaryl-CoA (HmG-CoA) reductase inhibitor lovastatin to human HEK cells transfected with the amyloid precursor protein (APP) reduces intracellular cholesterol/protein ratios by 50%, and markedly inhibits beta-secretase cleavage of newly-synthesized APP. Exogenous water-solubili...

journal_title：Neuroreport

authors： Frears ER,Stephens DJ,Walters CE,Davies H,Austen BM

更新日期：1999-06-03 00:00:00

abstract：:Regional variation in the distribution of SP and NFT within the brain is well documented. Consideration of such variation is potentially of help in formulating models of disease progression. Several models propose that pathological changes in Alzheimer's disease (AD) progress in a step-wise fashion along neuronally co...

journal_title：Neuroreport

authors： Shukla C,Bridges LR

更新日期：1999-12-16 00:00:00

abstract：:CEP-1347 inhibits the signalling pathway of c-jun-N-terminal kinase, and is neuroprotective in vivo and in vitro. Embryonic chick dorsal root ganglion neurones are dependent on NGF for survival and neurite outgrowth; NGF withdrawal results in apoptotic cell death. We examined the neuroprotective and neurite outgrowth ...

journal_title：Neuroreport

authors： Bilsland JG,Harper SJ

更新日期：2003-05-23 00:00:00

abstract：:Event-related brain potentials were examined in 6 to 8-year-old children with primary language disorder before and after a 5-week narrative-based language intervention. Participants listened to sentences ending with semantically congruous or incongruous words. By comparison with typical controls, the children with pri...

journal_title：Neuroreport

authors： Popescu M,Fey ME,Lewine JD,Finestack LH,Popescu EA

更新日期：2009-08-05 00:00:00

abstract：:Prefrontal delay-period activity represents a neural mechanism for the active maintenance of information and needs to be controlled by some signal to appropriately operate working memory. To examine whether reward-delivery acts as this signal, the effects of delay-period activity in response to unexpected reward-deliv...

journal_title：Neuroreport

authors： Ichihara-Takeda S,Takeda K,Funahashi S

更新日期：2010-03-31 00:00:00

abstract：OBJECTIVE:The current study aims to investigate whether computer generated (CG) expressions of emotion evoke similar emotional appraisal processing in the lateral orbitofrontal cortex (lOFC) compared to real human expressions, as well as how speech cues would influence the processing. METHODS:Functional near-infrared ...

journal_title：Neuroreport

authors： Zhao T,Chen J,Wang L,Yan N

更新日期：2020-04-08 00:00:00

abstract：:We localized the gene expression of angiotensin II receptor subtypes (AT1A, AT1B, and AT2) in 2-week-old rat brain by in situ hybridization using subtype specific riboprobes. AT1A receptor mRNA but not AT1B or AT2 receptor mRNA was expressed in the subfornical organ and paraventricular nucleus of the hypothalamus. AT1...

journal_title：Neuroreport

authors： Johren O,Inagami T,Saavedra JM

更新日期：1995-12-15 00:00:00

abstract：:The hypothesis of a general (i.e. cross-modal) temporal processing deficit in dyslexia was tested by examining rapid processing in both the auditory and the visual system in the same children with dyslexia. Participants were 10- to 12-year-old dyslexic readers and age-matched normal reading controls. Psychophysical th...

journal_title：Neuroreport

authors： Van Ingelghem M,van Wieringen A,Wouters J,Vandenbussche E,Onghena P,Ghesquière P

更新日期：2001-11-16 00:00:00

abstract：:Metabolic hypofunction is a common finding in a number of neurodegenerative diseases, including Alzheimer's disease (AD). The strong linkage between the amyloid precursor protein (APP) and AD led us to examine whether over-expression of this protein in CNS-type cells had an effect on mitochondria. We found abnormal mo...

journal_title：Neuroreport

authors： Grant SM,Shankar SL,Chalmers-Redman RM,Tatton WG,Szyf M,Cuello AC

更新日期：1999-01-18 00:00:00

abstract：:Neuroimaging techniques, such as fMRI, PET and near-infrared spectroscopy, monitor task-related neuronal activations in the brain indirectly through the associated neurovascular/metabolic responses. To assess the primary neuronal activations directly, magnetoencephalography was combined here with a mechanical modulati...

journal_title：Neuroreport

authors： Mackert BM,Wübbeler G,Leistner S,Trahms L,Curio G

更新日期：2001-06-13 00:00:00

abstract：:We used whole-cell recording to identify, for the first time, GABAergic tonic current in subpopulations of substantia gelatinosa neurons in mouse spinal cord slices. Application of the gamma-aminobutyric acid type A receptor antagonist bicuculline revealed tonic currents in 49 of 73 substantia gelatinosa neurons. Thes...

journal_title：Neuroreport

authors： Takahashi A,Mashimo T,Uchida I

更新日期：2006-08-21 00:00:00

abstract：:Mesencephalic astrocyte-derived neurotrophic factor (MANF) - one of a new class of astrocyte-derived human proteins--selectively promotes the survival of dopamine neurons of the ventral midbrain. Using the whole-cell clamp technique, we looked for acute effects of MANF on gamma-aminobutyric acid type A (GABAA) recepto...

journal_title：Neuroreport

authors： Zhou C,Xiao C,Commissiong JW,Krnjević K,Ye JH

更新日期：2006-02-27 00:00:00

abstract：:Amygdala and insula hyper-reactivity to threat is implicated in social anxiety disorder (SAD) yet inconsistencies in activation have been reported. One source of variance are individual differences in 5-HTTLPR genotype where the short (S), relative to long (L) allele, corresponds with greater amygdala activation. Howe...

journal_title：Neuroreport

authors： Klumpp H,Fitzgerald DA,Cook E,Shankman SA,Angstadt M,Phan KL

更新日期：2014-08-20 00:00:00