Abstract:
:We localized the gene expression of angiotensin II receptor subtypes (AT1A, AT1B, and AT2) in 2-week-old rat brain by in situ hybridization using subtype specific riboprobes. AT1A receptor mRNA but not AT1B or AT2 receptor mRNA was expressed in the subfornical organ and paraventricular nucleus of the hypothalamus. AT1B as well as AT1A receptor mRNA were found in the cerebral cortex and hippocampus. Conversely, AT2 receptor mRNA, but not AT1A or AT1B, was expressed in the medial geniculate nucleus and inferior olive. Our results indicate that AT1A receptors are involved in the well known central functions of angiotensin II. These results also support the hypothesis of the involvement of AT2 receptors in sensory and motor function.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Johren O,Inagami T,Saavedra JMdoi
10.1097/00001756-199512150-00024subject
Has Abstractpub_date
1995-12-15 00:00:00pages
2549-52issue
18eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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