Interaction between the intracellular Ca2+ stores in rat dissociated hippocampal neurones.

Abstract:

:The interaction between the Ca(2+)-activated K+ currents (IK(Ca)) induced by acetylcholine (ACh), 1-aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R)-ACPD) and caffeine in rat hippocampal CA1 neurones was investigated to examine the functional independence between IP3- and Ca(2+)-sensitive Ca2+ stores. Pretreatment with either ACh or (1S,3R)-ACPD almost completely suppressed the subsequent IK(Ca) induced by another. Pretreatment with caffeine partially suppressed the IK(Ca) induced by either ACh or (1S,3R)-ACPD, although the inhibitory effect varied among the neurones, while pretreatment with either ACh or (1S,3R)-ACPD also partially inhibited the caffeine-induced IK(Ca). Continuous treatment with ryanodine and thapsigargin nonselectively decreased both the caffeine- and ACh-induced IK(Ca). These results thus indicate a close interaction between IP3- and Ca(2+)-sensitive stores and also suggest that the relative size of both stores and the closeness between them differ among neurones.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Imanishi T,Yamanaka H,Rhee JS,Akaike N

doi

10.1097/00001756-199605310-00020

subject

Has Abstract

pub_date

1996-05-31 00:00:00

pages

1421-6

issue

8

eissn

0959-4965

issn

1473-558X

journal_volume

7

pub_type

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