Abstract:
:The interaction between the Ca(2+)-activated K+ currents (IK(Ca)) induced by acetylcholine (ACh), 1-aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R)-ACPD) and caffeine in rat hippocampal CA1 neurones was investigated to examine the functional independence between IP3- and Ca(2+)-sensitive Ca2+ stores. Pretreatment with either ACh or (1S,3R)-ACPD almost completely suppressed the subsequent IK(Ca) induced by another. Pretreatment with caffeine partially suppressed the IK(Ca) induced by either ACh or (1S,3R)-ACPD, although the inhibitory effect varied among the neurones, while pretreatment with either ACh or (1S,3R)-ACPD also partially inhibited the caffeine-induced IK(Ca). Continuous treatment with ryanodine and thapsigargin nonselectively decreased both the caffeine- and ACh-induced IK(Ca). These results thus indicate a close interaction between IP3- and Ca(2+)-sensitive stores and also suggest that the relative size of both stores and the closeness between them differ among neurones.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Imanishi T,Yamanaka H,Rhee JS,Akaike Ndoi
10.1097/00001756-199605310-00020subject
Has Abstractpub_date
1996-05-31 00:00:00pages
1421-6issue
8eissn
0959-4965issn
1473-558Xjournal_volume
7pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Hyperbaric oxygen (HBO) therapy and neural stem cell (NSC) transplantation can improve traumatic brain injury (TBI) clinically. This study aimed to investigate the mechanism of HBO promoting NSC proliferation and neurological recovery after TBI. Twenty-four Sprague-Dawley rats were divided randomly into three groups: ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000901
更新日期:2017-12-13 00:00:00
abstract::The precise role of prostaglandin-D-synthase (beta-trace protein), the major constituent of cerebrospinal fluid, is unclear. In the present study, a sensitive and highly specific fluoroimmunoassay was developed. The measurement of the enzyme levels in rat CSF revealed a developmental change in the CSF levels with the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803300-00028
更新日期:1998-03-30 00:00:00
abstract::Neuroimaging evidence suggests that human Brodmann area 5 (BA5) within the superior parietal lobule contributes to movement planning. However, a causal role for the contribution of BA5 to preparatory processes has yet to be reported. We used paired-pulse transcranial magnetic stimulation to investigate the influence o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000655
更新日期:2016-09-28 00:00:00
abstract::The amyloid cascade hypothesis suggests that amyloid precursor protein (APP) proteolytic processing is a key event in the pathogenesis of Alzheimer's disease (AD). The enzymes beta-site APP cleaving enzyme (BACE) and A disintegrin and metalloproteinase 10 (ADAM10) play an important role in APP proteolysis. We measured...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200211150-00008
更新日期:2002-11-15 00:00:00
abstract:OBJECTIVE:We sought to determine whether cortical excitability, measured via transcranial magnetic stimulation (TMS), is associated with cognition in healthy individuals and whether gender and education have an impact on this relationship. METHODS:Fifty-four healthy individuals (31 males, mean age = 41.94, SD = 21.98;...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001392
更新日期:2020-03-04 00:00:00
abstract::A lexical decision experiment was conducted while event related potentials (ERPs) were recorded. The word frequency and the first syllable frequency of each word were manipulated. Results showed that, while high frequency words produced less negative amplitudes in the N400 time window than low frequency words, the inv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200403010-00032
更新日期:2004-03-01 00:00:00
abstract::Peripheral nervous system injury may be corrected by surgical repair, but in many cases this is not possible and will result in loss of motor and sensory function. Schwann cells provide many neurotrophic signals essential for axon regeneration and immediately after injury inflammatory cytokines are released necessary ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200403010-00022
更新日期:2004-03-01 00:00:00
abstract::Spinally administered adenosine reduces hypersensitivity in animals and humans with nerve injury, but also causes transient pain in humans and reduces tonic inhibition in spinal neurons. Nerve injury results in increased tonic spinal cord adenosine A1 receptor activation, consistent with a role for adenosine to genera...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000239949.37825.e9
更新日期:2006-10-23 00:00:00
abstract::The serotonin transporter (SERT) terminates serotonergic neurotransmission by rapid reuptake of 5-hydroxytryptamine (5-HT) into the nerve terminal or axonal varicosities. SERT represents the target of various antidepressants which inhibit 5-HT transport and are widely used for the pharmacotherapy of depression. Here, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107200-00027
更新日期:2001-07-20 00:00:00
abstract::The rat synaptosomal membrane antigen D3, which has been studied for more than 20 years since its first demonstration as a brain-specific protein, was shown to bind monoclonal antibodies to SNAP-25, a presynaptic plasma membrane-associated protein. In addition to SNAP-25, anti-D3 antiserum also precipitated two polype...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199512000-00017
更新日期:1995-12-29 00:00:00
abstract::The 29 amino acid neuropeptide galanin is normally expressed in < 5% of sensory neurons in the adult dorsal root ganglia. After nerve transection (axotomy), the galanin content of the dorsal root ganglia rises 120-fold and the peptide is then expressed in > 50% of neurons. Published data suggest that galanin plays a r...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200211150-00028
更新日期:2002-11-15 00:00:00
abstract::This study aimed to evaluate the potential of bone marrow stromal cells for treatment of inner ear diseases. Autologous marrow cells labeled with Dil were implanted into the inner ear of five gentamicin-treated chinchillas. Histological analysis 3 weeks later revealed robust survival of grafted marrow cells in multipl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200401190-00001
更新日期:2004-01-19 00:00:00
abstract::The study aimed to compare the whole-brain gray matter volume (GMV) and white matter volume (WMV) difference between primary angle closure glaucoma (PACG) patients and health controls (HCs) using a voxel-based morphometry method. A total of 27 patients with PACG (17 males and 10 females) and 27 HCs (17 males and 10 fe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001126
更新日期:2018-11-07 00:00:00
abstract::In order to accomplish desired movements, the nervous system must specify the movement dynamics: it must provide a signal that compensates for the mechanical constraints encountered during movement. Here we tested whether the population activity of Purkinje cells in the cerebellum specifies the dynamics for pursuit ey...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200004070-00029
更新日期:2000-04-07 00:00:00
abstract::This study shows distributions of lacZ-positive cells in the vestibular labyrinthine explants of young guinea pigs with mature ears. When adenovirus lacZ vectors were administered to the vestibular labyrinth following removal of the otoconial membrane, lacZ-positive cells were observed in the mesothelial cells in the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112210-00032
更新日期:2001-12-21 00:00:00
abstract::N-methyl-D-aspartate (NMDA) receptors are hetero-oligomeric receptor-channel complexes composed of NR1 and NR2 subunits. Subunit composition determines the properties of NMDA receptor subtypes. However, the molecular mechanisms regulating their subunit composition are unknown. Using reverse transcription (RT)-competit...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199712010-00015
更新日期:1997-12-01 00:00:00
abstract::Face processing deficits are characteristic of autism spectrum conditions. However, event-related potential studies of autism spectrum conditions have found inconsistent results for the face selective N170 component. In this study, 15 adult males with autism spectrum conditions and 15 matched, typically developing con...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/wnr.0b013e328334311b
更新日期:2010-04-21 00:00:00
abstract::HEL 92.1.7 cells were immobilized among nerve growth factor (NGF)-differentiated PC12 cells. Nicotine caused an immediate Ca2+ mobilisation in the PC12 cells followed by a delayed secondary Ca2+ response in the HEL 92.1.7 cells. The Ca2+ elevation in response to nicotine in PC12 cells was abolished by Na+ removal. The...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207020-00017
更新日期:2002-07-02 00:00:00
abstract::Neurotrophins are promising candidates to slow the progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease in which spinal and cortical motoneurons selectively degenerate. In a long-term in vitro model, malonate-induced toxicity and cell death of motoneurons have been demonstrated. Here we stud...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105250-00013
更新日期:2001-05-25 00:00:00
abstract::Although a large amount of studies have manifested resting state electroencephalogram oscillatory abnormalities in schizophrenia and their first-degree relatives and in schizotype, the results are far from consistent and no research found any relationship between electroencephalograph (EEG) abnormalities and schizotyp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001350
更新日期:2019-12-10 00:00:00
abstract::Automatic phrase-building processes were investigated in second-language (L2) learners of French (native German speakers). Event-related brain potentials were recorded while participants listened to syntactically or semantically correct or incorrect French sentences containing a subject-modifying relative clause. Phra...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f1d518
更新日期:2007-12-03 00:00:00
abstract::Nogo-66 receptor was first identified in neurons. Recently, it was demonstrated in glial cells as well. Our previous study on the expression of Nogo-66 receptor in the cerebellum of the rat surprisingly found its location at the glial gap junctions. Here, we present our study on Nogo-66 receptor in the rat posterior p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200604240-00010
更新日期:2006-04-24 00:00:00
abstract::We examined the effect of a nonphotic stimulus (running in a novel wheel) on the induction of Fos-related proteins in the two well-established neural components of the circadian clock: the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) of the lateral geniculate complex. There was no induction of F...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199207000-00007
更新日期:1992-07-01 00:00:00
abstract::Fluoxetine, a serotonin-selective reuptake inhibitor, exerts antidepressant and antianxiety effects on major depressive and anxiety disorders. Previous studies suggest that treatment with fluoxetine influences the expression of various proteins that are involved in proliferation, differentiation, and apoptosis in the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000284
更新日期:2014-12-03 00:00:00
abstract::Single unit recordings were made from the ventral posterior lateral thalamus of anaesthetized rats to characterize responses to the activation of new receptive fields induced by either local anaesthesia or amputation. Receptive fields confined to single digits were identified and evoked unit responses to the stimulati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::Caffeine is a widely self-administered psychostimulant with purported neuroprotective and procognitive effects in rodent models of aging. The cholinergic basal forebrain is important for arousal and attention and is implicated in age-related cognitive decline. Accordingly, we determined the effects of caffeine on chol...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283329c3a
更新日期:2009-12-09 00:00:00
abstract::It is difficult to induce long-term potentiation (LTP) in CA1 of hippocampal slices from 120-day-old rats when a single 100 Hz, 1 s tetanus is administered in extracellular solution containing 2.0 mM calcium and 2.0 mM magnesium. However, in the presence of 2.5 mM calcium and 1.3 mM magnesium LTP is reliably induced b...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199811160-00022
更新日期:1998-11-16 00:00:00
abstract::Scanning laser-Doppler flowmetry (SLDF) combines laser-Doppler flowmetry and laser scanning to provide images of cerebral blood flow (CBF) with high spatial and temporal resolution. We investigated the contribution of single vascular elements to the local increase of CBF accompanying increased neuronal activity in hal...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911080-00002
更新日期:1999-11-08 00:00:00
abstract::Adenosine has an anticonvulsant effect in various models of epilepsy. This effect appears to be mediated through the activation of adenosine A1 receptors (A1Rs). We immunohistochemically investigated the changes of A1Rs expression in kainate-treated and hippocampus-kindled rats as chronic models of epilepsy. In the no...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911260-00014
更新日期:1999-11-26 00:00:00
abstract::Although valproate (VPA) is used widely in the treatment of bipolar mood disorder and epilepsy, the precise mechanism of action in the brain remains elusive. In this study, we investigated the effects of subchronic VPA administrations on the expression of the cyclin-dependent kinase inhibitor (Cdkn) family in the hipp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000448
更新日期:2015-10-21 00:00:00