Abstract:
:The serotonin transporter (SERT) terminates serotonergic neurotransmission by rapid reuptake of 5-hydroxytryptamine (5-HT) into the nerve terminal or axonal varicosities. SERT represents the target of various antidepressants which inhibit 5-HT transport and are widely used for the pharmacotherapy of depression. Here, we have analyzed the function of SERT stably expressed in HEK 293 cells upon exposure to citalopram, a selective serotonin reuptake inhibitor (SSRI), with respect to 5-HT transport activity and protein expression as estimated by ligand binding experiments. Our results show that long-term exposure to an SSRI causes a down-regulation of transport activity as revealed by a reduction of the maximal transport rate, without affecting substrate affinity, accompanied by a decrease in ligand binding sites.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Horschitz S,Hummerich R,Schloss Pdoi
10.1097/00001756-200107200-00027subject
Has Abstractpub_date
2001-07-20 00:00:00pages
2181-4issue
10eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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