Abstract:
:Brain slice preparations obtained from the rat were used to study cholinergic GABAergic interaction in mechanisms responsible for production of theta-like activity in hippocampal slices maintained in vitro. Bicuculline, a GABA-A antagonist, applied at 25 microM facilitated the effect of low concentration carbachol (25 microM) in inducing theta-like oscillations. At 100 microM, bicuculline increased the amplitude of carbachol-induced theta-like slow waves. This carbachol-bicuculline induced field potential was antagonized by a muscarinic blocker, atropine sulphate, and a GABA-A agonist, muscimol. These results provide in vitro evidence for cholinergic-GABAergic interaction in the production of hippocampal theta-like slow waves.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Konopacki J,Gołebiewski Hdoi
10.1097/00001756-199307000-00032subject
Has Abstractpub_date
1993-07-01 00:00:00pages
963-6issue
7eissn
0959-4965issn
1473-558Xjournal_volume
4pub_type
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