Cocaine alters body temperature and behavioral thermoregulatory responses.

Abstract:

:This study examined the effects of cocaine HCl and ambient temperature on the core body temperature of the rat. To further examine the mechanisms of cocaine-induced changes in temperature regulation, the effects of cocaine on behavioral thermoregulatory responses were also observed. At normal room temperature (20 degrees C) cocaine produced a reduction in core body temperature. At a higher ambient temperature (27 degrees C), however, cocaine produced hyperthermia. When given a choice between normal and warm environments, cocaine-injected animals spent significantly less time in the warm environment than did control animals, but had significantly lower core body temperature. These results suggest that cocaine treatment may lower the thermoregulatory set point.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Gonzalez LP

doi

10.1097/00001756-199301000-00028

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

106-8

issue

1

eissn

0959-4965

issn

1473-558X

journal_volume

4

pub_type

杂志文章
  • Impaired P600 in neuroleptic naive patients with first-episode schizophrenia.

    abstract::Deficits of working memory (WM) are recognized as an important pathological feature in schizophrenia. Since the P600 component of event related potentials has been hypothesized that represents aspects of second-pass parsing processes of information processing, and is related to WM, the present study focuses on P600 el...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200109170-00010

    authors: Papageorgiou C,Kontaxakis VP,Havaki-Kontaxaki BJ,Stamouli S,Vasios C,Asvestas P,Matsopoulos GK,Kontopantelis E,Rabavilas A,Uzunoglu N,Christodoulou GN

    更新日期:2001-09-17 00:00:00

  • Grating and plaid chrominance motion influences the suppressed ocular following response.

    abstract::Involuntary eye movements to foveal stimulation were measured in a monkey while it performed a fixation task. Second-order plaid motion generated higher velocities of eye movements than did first-order gratings, yet the latency of the early following response was no different for grating or plaid motion. Nevertheless,...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199902050-00032

    authors: Guo K,Benson PJ

    更新日期:1999-02-05 00:00:00

  • Nucleus basalis lesions decrease alpha- and kappa-bungarotoxins binding in rat cortex.

    abstract::A unilateral ibotenic acid lesion of the nucleus basalis magnocellularis in the rat, which is known to produce a reduction in cortical choline acetyltransferase activity and acetylcholine release, produces a decrease of 125I-alpha-bungarotoxin and 125I-kappa-bungarotoxin binding sites in the frontoparietal cortex of t...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199104000-00004

    authors: Sugaya K,Downen M,Giacobini E

    更新日期:1991-04-01 00:00:00

  • Neurotransmission in the brain by diffusion through the extracellular fluid: a review.

    abstract::Synaptic or 'hard wired' neurotransmission in the brain, subject to modulation by a class of substances called modulators, has been the dominant model of brain function. However, increasing evidence for alternate non-synaptic neurotransmission mechanisms is forcing consideration of a more inclusive model. Evidence is ...

    journal_title:Neuroreport

    pub_type: 杂志文章,评审

    doi:10.1097/00001756-199304000-00001

    authors: Bach-y-Rita P

    更新日期:1993-04-01 00:00:00

  • Event-related potential evidence for attentional inhibition of return in audition.

    abstract::Orienting attention to a spatial location facilitates responding to a subsequent target at that location, but inhibits the response if attention is oriented away from that location before the target appears there. This inhibitory effect of attention re-orienting, called inhibition of return (IOR), occurs in vision, he...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200303030-00019

    authors: Prime DJ,Tata MS,Ward LM

    更新日期:2003-03-03 00:00:00

  • SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells.

    abstract::Sirtuin 2 (SIRT2) is a member of the sirtuin family. Previous studies have suggested that SIRT2 mediates the cell death in models of Parkinson's disease and Huntington's disease. However, the role of SIRT2 in oxidative stress-induced cell death has remained unclear. In this study, we investigated the roles of SIRT2 in...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000192

    authors: Nie H,Hong Y,Lu X,Zhang J,Chen H,Li Y,Ma Y,Ying W

    更新日期:2014-08-06 00:00:00

  • Dominance for language and spatial processing: limited capacity of a single hemisphere.

    abstract::Using functional magnetic resonance imaging during word generation and spatial judgement (Landmark task), we investigated how hemispheric specializations for language and spatial processing interact in healthy individuals. We found individuals with atypical, right-hemispheric dominance for language to have more bilate...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200506210-00027

    authors: Jansen A,Flöel A,Menke R,Kanowski M,Knecht S

    更新日期:2005-06-21 00:00:00

  • Activity in motor areas while remembering action events.

    abstract::Episodic memory for simple commands is better following enacted than verbal encoding. This has been proposed to be due to the possibility to base retrieval on motor information. Here we used PET to test the hypothesis that motor brain areas show increased retrieval-related activity following enacted compared to verbal...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200007140-00027

    authors: Nilsson LG,Nyberg L,Klingberg T,Aberg C,Persson J,Roland PE

    更新日期:2000-07-14 00:00:00

  • Source analysis of epileptic discharges using multiple signal classification analysis.

    abstract::Multiple signal classification is an alternative to the traditional dipole fitting source analysis methods. Our aim was to assess the clinical usefulness of this algorithm and to compare the localization of the epileptiform electroencephalography discharges with the regions of altered cerebral blood flow in 10 patient...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000230517.93714.f6

    authors: Beniczky S,Oturai PS,Alving J,Sabers A,Herning M,Fabricius M

    更新日期:2006-08-21 00:00:00

  • Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia.

    abstract::Deficits in auditory sensory memory at the electrophysiological level as indexed by mismatch negativity and those in auditory verbal memory at the neuropsychological level have been independently demonstrated in previous studies of schizophrenia. We predicted a specific association between these indices in schizophren...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000221828.10846.ba

    authors: Kawakubo Y,Kasai K,Kudo N,Rogers MA,Nakagome K,Itoh K,Kato N

    更新日期:2006-07-17 00:00:00

  • Temporal prediction restores the evaluative processing of delayed action feedback: an electrophysiological study.

    abstract::The evaluative processing of the valence of action feedback is reflected by an event-related brain potential component called feedback-related negativity (FRN) or reward positivity (RewP). Recent studies have shown that FRN/RewP is markedly reduced when the action-feedback interval is long (e.g. 6000 ms), indicating t...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000657

    authors: Kimura K,Kimura M

    更新日期:2016-09-28 00:00:00

  • 3-Dimensional visualization of lesions in rat brain using magnetic resonance imaging microscopy.

    abstract::High-resolution (< 50 microm) magnetic resonance imaging microscopy (MRM) has been used to identify brain regions and localization of excitotoxin-induced lesions in fixed rat brains, subsequently confirmed using standard histology. The anatomical extent of lesions identified by MRM was identical to that seen in histol...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199903170-00014

    authors: Lester DS,Lyon RC,McGregor GN,Engelhardt RT,Schmued LC,Johnson GA,Johannessen JN

    更新日期:1999-03-17 00:00:00

  • Effects of the 5-HT1A agonist 8-OH-DPAT on food intake in food-deprived rats.

    abstract::The effects of 8-OH-DPAT were investigated on food intake in food-deprived rats in both non-operant and operant feeding paradigms. 8-OH-DPAT produced dose-related reductions in food intake in both paradigms. While the higher doses of 8-OH-DPAT used in this study (i.e. 125-500 micrograms kg-1) produced a number of ster...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199211000-00019

    authors: Ebenezer IS

    更新日期:1992-11-01 00:00:00

  • Modulation of striatal aspartate and dynorphin B release by cholecystokinin (CCK-8) studied in vivo with microdialysis.

    abstract::Sulphated cholecystokinin-8 (CCK-8) given into the neostriatum of the rat by in vivo microdialysis produced a concentration-dependent (1-100 microM) increase in extracellular aspartate (Asp) and dynorphin B (Dyn B), but not in glutamate, GABA or dopamine levels. The increase in Asp levels produced by 10 microM CCK-8 w...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199411000-00024

    authors: You ZB,Pettersson E,Herrera-Marschitz M,Hökfelt T,Terenius L,Nylander I,Goiny M,Hughes J,O'Connor WT,Ungerstedt U

    更新日期:1994-11-21 00:00:00

  • Context-dependent representation of reinforcement in monkey amygdala.

    abstract::It has been reported that neurons in the amygdala respond to visual cues that predict reward and aversive outcomes. However, it remains unclear whether the representation of reinforcement in the amygdala depends on the relative preference for an outcome compared with another simultaneously available outcome. In this s...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283294a2f

    authors: Hirai D,Hosokawa T,Inoue M,Miyachi S,Mikami A

    更新日期:2009-04-22 00:00:00

  • Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers.

    abstract::Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) are assumed to provide trophic support via a target-derived, retrograde mechanism of action. However, recent studies suggest that neurotrophic factors can act in an autocrine fashion and perhaps even in an anterograde direction similar to neurotrans...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199705260-00008

    authors: Smith MA,Zhang LX,Lyons WE,Mamounas LA

    更新日期:1997-05-27 00:00:00

  • Perception and recognition discriminated in the mouse auditory cortex by c-Fos labeling.

    abstract::The functions of the fields of the mammalian auditory cortex in sound perception and recognition are unknown. We used Fos (a protein of the inducible immediate-early gene c-fos) as a cellular marker of activated brain areas to show in the mouse (Mus domesticus) that sound is processed differentially in auditory cortic...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199908020-00022

    authors: Fichtel I,Ehret G

    更新日期:1999-08-02 00:00:00

  • Muscarinic cholinoceptive reticular mechanisms and parabrachial neuron discharge: a novel experimental approach.

    abstract::This study examined the hypothesis that cholinergic receptor mechanisms within the gigantocellular tegmental field (FTG) of the medial pontine reticular formation can cause state-dependent changes in the firing rates of parabrachial nuclear complex (PBNC) neurons. Using intact, unanesthetized cats, long-term recording...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199303000-00011

    authors: Gilbert KA,Lydic R

    更新日期:1993-03-01 00:00:00

  • Regenerating adult rat retinal axons reconnect with target neurons in-vitro.

    abstract::We have established an in-vitro coculture-system of adult rat retina with fetal midbrain explants to examine whether regenerating central nervous system axons are still able to recognize appropriate target neurons. Our results show that the retinal ganglion cell axons regenerate their axons and reinnervate the retino-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199110000-00007

    authors: Bähr M,Eschweiler GW

    更新日期:1991-10-01 00:00:00

  • Temporal dynamics of the consistency effect in reading Chinese: an event-related potentials study.

    abstract::This study aimed to explore the temporal dynamics of the consistency effect in reading Chinese phonograms. High-consistency and low-consistency characters were used in the homophone judgment task, and the event-related potentials were recorded. The data showed that low-consistency characters elicited greater N170 ampl...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328010d4e4

    authors: Lee CY,Tsai JL,Chan WH,Hsu CH,Hung DL,Tzeng OJ

    更新日期:2007-01-22 00:00:00

  • Identification of short latency auditory responsive neurons in the cat dentate nucleus.

    abstract::Intracellular recordings of activity in response to acoustic stimuli were obtained from units of the dentate nucleus of conscious cats. Twelve units with short latency responses to 70 dB clicks or hisses were injected intracellularly with biocytin and identified morphologically. The identified cells were small, relati...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199408150-00006

    authors: Xi MC,Woody CD,Gruen E

    更新日期:1994-08-15 00:00:00

  • Between-site reliability of startle prepulse inhibition across two early psychosis consortia.

    abstract::Prepulse inhibition (PPI) and reactivity of the acoustic startle response are widely used biobehavioral markers in psychopathology research. Previous studies have demonstrated that PPI and startle reactivity exhibit substantial within-site stability; however, between-site stability has not been established. In two sep...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283637845

    authors: Cadenhead KS,Addington J,Cannon TD,Cornblatt BA,de la Fuente-Sandoval C,Mathalon DH,Perkins DO,Seidman LJ,Tsuang M,Walker EF,Woods SW,Bachman P,Belger A,Carrión RE,Donkers FC,Duncan E,Johannesen J,León-Ortiz P,Light G

    更新日期:2013-08-07 00:00:00

  • Secondary inhibition of 2-ketoglutarate dehydrogenase complex by MPTP.

    abstract::The parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridine (MPP+) acts through inhibition of complex I of the electron transport chain. Recent evidence suggests that it may also act through inhibition of 2-ketoglutarate dehydrogenase complex (KDHC). We confirmed this observation in isolated rat liver mitochondria ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199808240-00018

    authors: Joffe GT,Parks JK,Parker WD Jr

    更新日期:1998-08-24 00:00:00

  • Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.

    abstract::Recently it has been reported that a missense G(88)C mutation within exon 3 and a missense G(209)A mutation within exon 4 of the alpha-synuclein gene were linked to familial Parkinson's Disease (PD). We decided to investigate if these and any other mutations in exons 3 and 4 of the alpha-synuclein gene could be detect...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199812010-00029

    authors: El-Agnaf OM,Curran MD,Wallace A,Middleton D,Murgatroyd C,Curtis A,Perry R,Jaros E

    更新日期:1998-12-01 00:00:00

  • Guanine nucleotides block agonist-driven 45Ca2+ influx in chick embryo retinal explants.

    abstract::AMPA (EC50 = 1.0 x 10(-6) M) and NMDA (EC50 = 1.3 x 10(-4) M) trigger 45Ca2+ influx in 13-day chick embryonic retinal explants. This agonist-driven cationic flux is specifically inhibited by typical competitive antagonists, such as 6,7-dinitroquinoxaline-2,3-dione (DNQX) and 2-amino-7-phosphonoheptanoate (AP7), respec...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200007140-00047

    authors: Burgos JS,Barat A,Ramírez G

    更新日期:2000-07-14 00:00:00

  • Cortical evoked potentials due to motion contrast in the blind hemifield.

    abstract::Subcortical visual inputs to motion-selective cortex in primates survive after damage to the primary visual cortex (area 17/V1). Activation of human motion cortex was examined using scalp electrodes in a V1-damaged hemianope. Blind field motion-onset visual evoked potentials (VEPs) shared many of the characteristics a...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199911260-00024

    authors: Benson PJ,Guo K,Hardiman MJ

    更新日期:1999-11-26 00:00:00

  • Protein kinase B is involved in Nogo-66 inhibiting neurite outgrowth in PC12 cells.

    abstract::Nogo-A, a member of the reticulon family, is one of the most important myelin-associated inhibitors for axonal growth, regeneration, and plasticity in the central nervous system. RhoA has been targeted pharmacologically to promote neurite outgrowth and functional recovery in the brain and spinal cord. However, the und...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32834a58e8

    authors: Wang H,Shen J,Xiong N,Zhao H,Chen Y

    更新日期:2011-10-26 00:00:00

  • Component-dependent urine responses in the rat accessory olfactory bulb.

    abstract::To investigate how pheromonal information is processed in the rat accessory olfactory bulb, we optically imaged intrinsic signals to obtain high-resolution maps of activation induced by urinary stimulation. Application of volatile components in male urine mainly induced activation in the anterior accessory olfactory b...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000239950.14954.59

    authors: Sugai T,Yoshimura H,Kato N,Onoda N

    更新日期:2006-11-06 00:00:00

  • Responses of microglia and neural progenitors to mechanical brain injury.

    abstract::Neural cells have distinct responses to CNS injury; however, neural progenitor response to CNS injury is not yet documented. Stab injury combined with injection of bromodeoxyuridine (BrdU), a thymidine analog, into adult rat cortex above the lateral ventricle for 10 min resulted in activated microglia/macrophage infil...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199908020-00012

    authors: Tzeng SF,Wu JP

    更新日期:1999-08-02 00:00:00

  • Regulation of serotonin release in the Syrian hamster intergeniculate leaflet region.

    abstract::In mammals, the thalamic intergeniculate leaflet (IGL) conveys behavioral (non-photic) phase-resetting information to the circadian clock of the suprachiasmatic nucleus. Here we report a 24 h fluctuation in in vivo serotonin release in the hamster IGL region, peaking at night. Novel wheel exposure at midday, a stimulu...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200401190-00021

    authors: Grossman GH,Farnbauch L,Glass JD

    更新日期:2004-01-19 00:00:00