Abstract:
:This study examined the effects of cocaine HCl and ambient temperature on the core body temperature of the rat. To further examine the mechanisms of cocaine-induced changes in temperature regulation, the effects of cocaine on behavioral thermoregulatory responses were also observed. At normal room temperature (20 degrees C) cocaine produced a reduction in core body temperature. At a higher ambient temperature (27 degrees C), however, cocaine produced hyperthermia. When given a choice between normal and warm environments, cocaine-injected animals spent significantly less time in the warm environment than did control animals, but had significantly lower core body temperature. These results suggest that cocaine treatment may lower the thermoregulatory set point.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Gonzalez LPdoi
10.1097/00001756-199301000-00028subject
Has Abstractpub_date
1993-01-01 00:00:00pages
106-8issue
1eissn
0959-4965issn
1473-558Xjournal_volume
4pub_type
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