Abstract:
:It has been reported that intracerebroventricular (i.c.v.) injection of nociception/orphanin FQ (OFQ) can antagonize morphine analgesia, whereas i.c.v. OFQ antibody can reverse morphine tolerance. Nocistatin (NST) is a recently characterized neuropeptide possessing an antagonizing effect on OFQ. Here we examine whether i.c.v. NST would result in a reversal of morphine tolerance. The results showed that: (1) i.c.v. NST at doses of 0.005, 0.05, 0.5, 5 or 50 ng per rat produced a bell-shaped dose-dependent reversal of chronic morphine tolerance, with maximum response at 0.5 ng. (2) Acute morphine tolerance could also be reversed, albeit partially, by i.c.v. NST at 0.5 ng. (3) The reversal of acute and chronic morphine tolerance by NST was completely abolished when NST (0.5 ng) was co-injected with (8 microg) OFQ. Since OFQ and NST are derived from the same preprohormone, the profile of its splicing in the CNS may play an important role in determining the effectiveness of morphine analgesia.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Sun RQ,Zhao CS,Wang HJ,Jing Z,Wang W,Yang K,Wang Y,Chang JK,Han JSdoi
10.1097/00001756-200106130-00054subject
Has Abstractpub_date
2001-06-13 00:00:00pages
1789-92issue
8eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::We examined the protective effects of N-acetylcysteine (NAC) on the death of glia-free neurons in culture. Under normoxic conditions, the protection by NAC was observed only in cystine-free but not complete medium. When the cells were cultured under hypoxic conditions, NAC much elongated their survival even in the pre...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328337765c
更新日期:2010-04-21 00:00:00
abstract::Voltage-gated sodium channels (VGSCs) are concentrated in the postsynaptic membrane at the adult rat neuromuscular junction (NMJ). We have used immunolabelling to determine the pattern of initial VGSC accumulation during development. At birth, but not 3 days before, VGSC labelling is detectable at the NMJ and in the p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199806220-00014
更新日期:1998-06-22 00:00:00
abstract::The inward rectifier Kir4.1, composed of KCNJ10 K channel subunits, plays an essential role in inner ear K homeostasis. We have investigated the developmental expression and localization of KCNJ10 (Kir4.1) in the guinea pig inner ear using semi-quantitative reverse transcription polymerase chain reaction and immunohis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000208999.25234.91
更新日期:2006-04-03 00:00:00
abstract::Human neuroblastoma SH-SY5Y and small-cell lung carcinoma U1690 cells of neuroendocrine origin were exposed to morphine for 1 h, 3 h or 5 days. These treatments did not alter activities of AP-1, NF-kappa B and YY1 transcription factors in SH-SY5Y cells or NF-kappa B and YY1 in U1690 cells. Five-day morphine treatment,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1997-07-07 00:00:00
abstract::Group III metabotropic glutamate receptors (mGluR4, 6, 7, 8) are negatively coupled to adenylate cyclase and, when activated presynaptically, decrease the release of glutamate and GABA. We have used intracerebroventricular injections of agonists and antagonists believed to act selectively on these receptors to study t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199606170-00005
更新日期:1996-06-17 00:00:00
abstract::Paraoxonase polymorphisms have been associated with amyotrophic lateral sclerosis (ALS). Paraoxonases are detoxifying enzymes involved in the metabolism of organophosphates. We tested the hypothesis that genetic variation within paraoxonase genes would interact with the environmental exposure to paraoxonase substrates...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32831af220
更新日期:2009-01-28 00:00:00
abstract::The present study investigated the effect of lexical competition on the time course of spoken word recognition in Mandarin Chinese using a unimodal auditory priming paradigm. Two kinds of competitive environments were designed. In one session (session 1), only the unrelated and the identical primes were presented befo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000492
更新日期:2016-01-20 00:00:00
abstract::Functional brain imaging techniques hold many promises as the methods of choice for identifying areas involved in the execution of language functions. The success of any of these techniques in fulfilling this goal depends upon their ability to produce maps of activated areas that overlap with those obtained through st...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199901180-00026
更新日期:1999-01-18 00:00:00
abstract::Previous studies using magnetoencephalographic (MEG) recordings have revealed neuronal populations responding to discrete auditory stimuli in the supratemporal cortex of the human brain. We used the novel whole-head magnetometer (Neuromag-122) to determine whether regions outside the auditory cortex are activated by a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412300-00046
更新日期:1994-12-30 00:00:00
abstract::Two voltage-activated Na+ channel blockers, lamotrigine and flunarizine were applied ionophoretically to extracellularly recorded dorsal horn neurones to assess effects on activation by noxious (mustard oil) and innocuous (brush) stimuli. Lamotrigine and flunarizine caused significantly greater reductions in mustard o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199705060-00001
更新日期:1997-05-06 00:00:00
abstract::Widespread invasiveness, represented by the invasion and migration, is the most important characteristic of glioblastoma multiforme (GBM) and is the main reason for therapeutic failure and recurrence of the tumor. Hypoxia is one of the main microenvironment in determining tumor invasiveness. Therefore, intense efforts...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001156
更新日期:2018-12-12 00:00:00
abstract::In the anaesthetized rat, low frequency electrical stimulation of the Zusanli acupoint (S36) or noxious thermal stimulation caused by immersing the footpad in water at 52 degrees C caused marked expression of c-fos in the anterior lobe of the pituitary gland, as well as in the arcuate and some nearby hypothalamic nucl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199408150-00027
更新日期:1994-08-15 00:00:00
abstract::Hypoxia-inducible factor-1 (HIF-1) regulates the expression of neuroprotective genes such as erythropoietin (EPO). We investigated the mechanism by which zinc, an excitotoxin-like metal, regulates HIF-1 under hypoxic conditions in astrocytes. In hypoxic LN215 cells, HIF-1alpha stabilized and accumulated in the nucleus...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328304d9ac
更新日期:2008-07-02 00:00:00
abstract::This study examined the basis for introducing an ignoring task during cortical evoked response audiometry (CERA) using the N1-P2 response. Healthy hearing participants were assigned to two groups with and without an ignoring task (ignoring and listening groups) during CERA whose outcomes were compared with the pure-to...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833b502a
更新日期:2010-07-14 00:00:00
abstract::The whole cell configuration of the patch clamp technique was used to study the biophysical and pharmacological properties of voltage activated Ca2+ channel currents on hippocampal neurones cultured in the presence or absence of foetal calf serum. In the presence of serum cells were intensively immunostained with neur...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199504190-00008
更新日期:1995-04-19 00:00:00
abstract::Insulin-like growth factor (IGF)-I is essential for cerebellar granule neuron survival and a decline in IGF-I is implicated in various age-dependent processes. Here we show that IGF-I mRNA levels are decreased in the cerebellum of old rats compared with young rats and this was associated with increased cell death and ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200308260-00018
更新日期:2003-08-26 00:00:00
abstract::Immunohistochemical techniques were employed to examine the distribution of RNA-binding proteins A2 and B1 in the rat forebrain. Intense A2 and B1 immunolabeling were observed in the nucleoplasm of the neurons in the cerebral cortices, hippocampal formation, olfactory regions, caudate-putamen as well as the supraoptic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200009280-00012
更新日期:2000-09-28 00:00:00
abstract::To assess the effect of endothelial progenitor cells on the axon growth of cortex neurons, we transplanted CD133 cells derived from human peripheral blood to an organotypic coculture system consisting of spinal cord and cortex from neonatal rats. The axon growth from cortex to spinal cord was significantly promoted in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282ff6396
更新日期:2008-05-28 00:00:00
abstract::Rats with an experimental painful peripheral neuropathy (the chronic injury (CCI) model) display heatevoked hyperalgesia. There is now considerable evidence that nitric oxide (NO) and nitric oxide synthase are involved in the development of hyperalgesia in acute inflammatory pain states. The mechanisms responsible for...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199605310-00010
更新日期:1996-05-31 00:00:00
abstract::In rapid serial visual presentation of pictures, an early event-related brain potential component shows enlarged negativity over occipital regions for emotional pictures compared with neutral pictures. The present study examined whether the processing of emotional target pictures varies as a function of stimulus repet...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000203355.88061.c6
更新日期:2006-03-20 00:00:00
abstract::Physical exercise has many health benefits, including improved cardiovascular fitness, lean muscle development, increased metabolism, and weight loss, as well as positive effects on brain functioning and cognition. Recent evidence suggests that regular physical exercise may also affect the responsiveness of reward reg...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000029
更新日期:2013-12-04 00:00:00
abstract::To examine the relationship between plasma lipoproteins and apolipoproteins in men with convictions for violent offences, blood was obtained from 15 men with a history of violence who were serving prison sentences for violent offences, and 25 age-matched male controls from the staff of the Argyll and Bute Psychiatric ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199306000-00039
更新日期:1993-06-01 00:00:00
abstract::Whereas in the mature retina the glutamate agonist 2-amino-4-phosphonobutyric acid (APB) selectively activates currents in rod bipolar and ON-cone bipolar cells, recent molecular studies have suggested the possibility of a transient appearance of the APB-sensitive receptor in developing retinal ganglion cells. In the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611250-00013
更新日期:1996-11-25 00:00:00
abstract::Cyclooxygenase (COX)-2 is constitutively expressed in the superficial dorsal horn of the spinal cord, but its role in the spinal cord is still unclear. We examined the effect of intrathecally administered NS398, a selective COX-2 inhibitor and indomethacin, an non-selective COX-1 and COX-2 inhibitor, on the developmen...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812010-00019
更新日期:1998-12-01 00:00:00
abstract::The acute effects of ethanol and acetaldehyde on neuropeptide mRNA expression in the arcuate nucleus (ARC) was assessed. Acetaldehyde was increased in blood following ethanol with cyanamide (a potent inhibitor of aldehyde dehydrogenase) administration. Acetaldehyde is a toxin which can cause a variety of adverse effec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011090-00023
更新日期:2000-11-09 00:00:00
abstract::The transmissible spongiform encephalopathies (TSEs) invariably result in fatal neurodegeneration and accumulation of PrP, an abnormal form of the host prion protein PrP, encoded by the PRNP gene. A naturally occurring polymorphism (methionine/valine) at PRNP codon 129 is associated with variation in relative disease ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f1ca2f
更新日期:2007-12-03 00:00:00
abstract::Adrenomedullin (ADM) is a 52 amino acid peptide with multiple physiological functions and wide tissue distributions including brain. Recently, elevated plasma levels of ADM were found in patients with schizophrenia, bipolar affective disorder and autism, suggesting the involvement of ADM in the pathophysiology of ment...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000132202.69212.79
更新日期:2004-06-28 00:00:00
abstract::This study examined the relationship between social anxiety and the neural processing of threat in faces. Twenty-one adults with different levels of society anxiety were tested for their event-related potential responses to unattended threatening and nonthreatening faces, presented upright and upside-down, at three po...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/WNR.0b013e32830baadf
更新日期:2008-08-27 00:00:00
abstract::Blockade of L-type Ca2+ channels results in a decrease in firing frequency of neostriatal neurons. In contrast, N- and P/Q-types of Ca2+ channel cooperate to tune firing pattern, since both of these channel types have to be blocked to enhance firing frequency. Parameters of the intensity-frequency plot were differenti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200307010-00013
更新日期:2003-07-01 00:00:00
abstract::Absence seizures are known to originate from disruptions within the corticothalamocortical network; however, the precise underlying cellular and molecular mechanisms that induce hypersynchronicity and hyperexcitability are debated and likely to be complex and multifactorial. Recent studies implicate impaired thalamic ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000909
更新日期:2017-12-13 00:00:00