Abstract:
:Human neuroblastoma SH-SY5Y and small-cell lung carcinoma U1690 cells of neuroendocrine origin were exposed to morphine for 1 h, 3 h or 5 days. These treatments did not alter activities of AP-1, NF-kappa B and YY1 transcription factors in SH-SY5Y cells or NF-kappa B and YY1 in U1690 cells. Five-day morphine treatment, however, caused a twofold increase in the activity of a sequence-non-specific, spermidine-activated DNA-binding factor in U1690 cells. The morphine effect was prevented by the antagonist naloxone. The DNA-binding factor bound preferentially to double-stranded DNA ends. This fact and data on subunit composition, molecular masses of subunits, and supershift/inhibition by specific antibodies in a band shift assay, show the spermidine-activated factor to be identical with the Ku protein, the DNA-binding subunit of DNA-dependent protein kinase. The effect observed may be one of the mechanisms through which opioids influence gene regulation.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bakalkin G,Yakovleva T,Melzig M,Terenius Lsubject
Has Abstractpub_date
1997-07-07 00:00:00pages
2143-8issue
9-10eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::This review paper on visual mismatch negativity (MMN), an event-related brain potential component, provides arguments in favor of its theoretical importance in visual cognitive sciences. We propose that (a) previous visual MMN findings can be regarded as ample evidence for the existence of unintentional prediction abo...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/WNR.0b013e32834973ba
更新日期:2011-10-05 00:00:00
abstract::Several neurophysiological studies have highlighted the role of the midbrain periaqueductal gray matter (PAG) in the initiation of vocalization in various animal species, from frogs to primates. With regard to humans, only two cases of complete mutism following a lesion to the PAG have been reported so far. This artic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199903170-00004
更新日期:1999-03-17 00:00:00
abstract::Production and differentiation of olfactory neurons occur in spherical, multi-neuronal aggregates that form in cultures where dissociated newborn rat nasal cells are plated on to CNS glial cells. We show here that neuronal cell bodies were primarily located in the peripheral layers of the spheres, and almost every neu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199401000-00003
更新日期:1994-01-31 00:00:00
abstract::To define the significance of glutamate ionotropic receptors in sPLA -mediated neuronal cell death we used the NMDA receptor antagonist MK-801 and the AMPA receptor antagonist PNQX. In primary neuronal cell cultures both MK-801 and PNQX inhibited sPLA - and glutamate-induced neuronal death. [ H]Arachidonic acid releas...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200210280-00026
更新日期:2002-10-28 00:00:00
abstract::The present study examined the effect of pre-exposure to a moderate dose of caffeine (20 mg kg-1) on the acquisition of self-administration of cocaine (0.125 mg kg-1/infusion or 0.25 mg kg-1/infusion) in the rat. Rats pre-exposed to caffeine acquired self-administration more rapidly. Furthermore, sensitization to coca...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199101000-00013
更新日期:1991-01-01 00:00:00
abstract::Fluoxetine, a serotonin-selective reuptake inhibitor, exerts antidepressant and antianxiety effects on major depressive and anxiety disorders. Previous studies suggest that treatment with fluoxetine influences the expression of various proteins that are involved in proliferation, differentiation, and apoptosis in the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000284
更新日期:2014-12-03 00:00:00
abstract::Event-related potentials (ERPs) were measured from 24 chronic closed head injury (CHI) patients and 18 age- and education-matched controls. The oddball paradigm was applied while subjects were watching a silent movie. The standard (p=0.8) sound of 75 ms duration had a basic frequency of 500 Hz with harmonic partials o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105250-00043
更新日期:2001-05-25 00:00:00
abstract::The mechanism by which IL-1 beta exerts its actions in the brain during systemic inflammation is not fully understood, as neither IL-1 receptor gene expression nor IL-1 binding have been identified in significant levels in key areas that respond to IL-1 beta. Having hypothesized that perivascular nitric oxide (NO) mig...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611040-00008
更新日期:1996-11-04 00:00:00
abstract::Sound localization can be affected by vision; in the ventriloquism effect, sounds that are hard to localize within hearing become mislocalized toward the location of concurrent visual events. Here we tested whether spatial attention is drawn to the illusory location of a ventriloquized sound. The study exploited our p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200006260-00049
更新日期:2000-06-26 00:00:00
abstract::Functional MRI (fMRI) can detect changes from resting levels of blood flow and oxygenation during task performance (i.e. activation). We used a simple electrical nerve stimulation technique together with fMRI to study pain process in the human cortex. Images of the primary somatosensory (SI) and cingulate cortex (Cg) ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::The in-vivo extracellular release of acetylcholine (ACh) from the striatum of rats was measured by intracerebral microdialysis. The ACh levels were first estimated under normoxic conditions, after which the rats were exposed to either 10% or 5% oxygen for 1 h. The average ACh content was 2.9 pmol/20 min. During hypoxi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199011000-00005
更新日期:1990-11-01 00:00:00
abstract::Based on the results of recent in vitro studies, tau has been proposed to be involved in regulating signal transduction through the phospholipase C-gamma (PLC-gamma) signaling pathway. The present study provides support for the physiological relevance of this hypothesis by demonstrating the existence of a tau-PLC-gamm...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199801050-00014
更新日期:1998-01-05 00:00:00
abstract::Successful practice of clinical deep brain stimulation (DBS) calls for basic research on the mechanisms and explorations of new indications in animals. In the article, a new implantable, single-channel, low-power miniature device is proposed, which may transmit pulses chronically into the brain nucleus of freely movin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000727
更新日期:2017-02-08 00:00:00
abstract::Group III metabotropic glutamate receptors (mGluR4, 6, 7, 8) are negatively coupled to adenylate cyclase and, when activated presynaptically, decrease the release of glutamate and GABA. We have used intracerebroventricular injections of agonists and antagonists believed to act selectively on these receptors to study t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199606170-00005
更新日期:1996-06-17 00:00:00
abstract::For the majority of neurones in cat striate cortex, the response to an optimal stimulus presented to one eye is suppressed when a stimulus of substantially different orientation is presented to the other eye. In order to determine the true orientational tuning of the underlying inhibitory interactions in the absence o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199511000-00032
更新日期:1995-11-13 00:00:00
abstract::Modulation of the soleus H-reflex following galvanic vestibular stimulation (GVS) has been used to evaluate vestibulospinal tract function. It is not known whether this modulation is because of vestibular stimulation and/or cutaneous stimulation, and the suitable stimulating intensity of GVS for the modulation is not ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001086
更新日期:2018-09-05 00:00:00
abstract::During the development of central nervous system, radial glial cells support target-specific neuronal migration. We recently reported that after implantation of chitosan channels with complete spinal cord transection, the tissue bridging the spinal cord stumps contained axons and radial glial cells. The purpose of thi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833d9695
更新日期:2010-09-15 00:00:00
abstract::The whole cell configuration of the patch clamp technique was used to study the biophysical and pharmacological properties of voltage activated Ca2+ channel currents on hippocampal neurones cultured in the presence or absence of foetal calf serum. In the presence of serum cells were intensively immunostained with neur...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199504190-00008
更新日期:1995-04-19 00:00:00
abstract::The immediate-early genes, especially c-fos, have been suggested to have an important role in neuronal plasticity and memory. However, it has been difficult to determine if in fact c-fos can participate in control of behaviour. Here we can report that direct unilateral infusion into the rat neostriatum of an antisense...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199312000-00024
更新日期:1993-12-13 00:00:00
abstract::The time-dependent effect of transcranial direct current stimulation (tDCS) on working memory was investigated by applying anodal stimulation over the left prefrontal cortex. This single-blind, sham-controlled crossover study recruited 15 healthy participants. A three-back verbal working-memory task was performed befo...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/WNR.0b013e3282f2adfd
更新日期:2008-01-08 00:00:00
abstract::The balance between heat production (metabolism) and heat removal (blood flow) helps in keeping the temperature of the brain constant. In patients with moyamoya disease, this balance may be disturbed. The purpose of this study was to assess the thermal pathophysiology of the brain in patients with moyamoya disease. Th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833d6b7a
更新日期:2010-09-15 00:00:00
abstract::The pattern of distribution and co-localization of nitric oxide synthase (NOS) and quinacrine fluorescence (indicative of vesicular adenosine 5'-triphosphate, ATP), and co-localization of NADPH-diaphorase (NADPH-d) activity and NOS-immunoreactivity in the myenteric plexus of pre-term human fetal (6-17 weeks of gestati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200001170-00002
更新日期:2000-01-17 00:00:00
abstract::To investigate the implications of duration of deafness in the rehabilitation of unilateral deafness utilizing cochlear implantation. From the ongoing prospective cochlear implantation in unilateral deafness study, we looked at five adults who received a cochlear implant for long-term unilateral deafness. Speech perce...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283642a93
更新日期:2013-09-11 00:00:00
abstract::The study was conducted to investigate the effect of serotonin depletion on nitric oxide-induced meningeal vascular response and cerebrovascular nociception. Nitroglycerin was infused i.v. to control and serotonin-depleted rats. Pial circulation was monitored by intravital fluorescent videomicroscopy and Fos immunorea...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200104170-00021
更新日期:2001-04-17 00:00:00
abstract::The role of dopaminergic pathways in the retina in controlling the functional state of the pineal was investigated. Dopaminergic agents were injected into the eyes of dark-adapted chickens which were maintained in the dark. Changes in the activity of N-acetyltransferase (NAT) in the retina and pineal were then monitor...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199502000-00010
更新日期:1995-02-15 00:00:00
abstract::In the visual modality adaptation to high temporal frequency can result in spatially localized apparent duration compression. The principal point of adaptation is thought to be early in the visual system, at which point temporal information is encoded within sustained (parvocellular) and transient (magnocellular) chan...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833d6bcb
更新日期:2010-09-15 00:00:00
abstract::Latest reports suggest the involvement of insulin in modulating memory. A few published in-vitro studies favor the antidementia effect of insulin. Thus, the present study aimed to evaluate the prophylactic role of insulin and its combination with glucose and its possible mechanism(s) in an aluminum chloride (AlCl3)-in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000799
更新日期:2017-06-14 00:00:00
abstract::In isolated neurons of Helix pomatia, a two-microelectrode voltage clamp technique was used to study the effect of Fe3+ on voltage-gated potassium currents: a low-threshold fast-inactivating current (I(A)) and a high threshold slow-inactivating current with calcium-dependent (I(C)) and calcium-independent (I(DR)) comp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282c48c1c
更新日期:2007-08-27 00:00:00
abstract::We investigated whether short-term saccadic adaptation modifies hand pointing. Subjects were presented with double-step targets, the second target jump occurring during the saccade to the first one and bringing the target back to 66% of the first target eccentricity, in order to reduce the gain of their gaze saccades....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199509000-00007
更新日期:1995-09-11 00:00:00
abstract::In the adult rat hippocampal formation, neurogenesis occurs in the dentate gyrus subgranular zone (SGZ). We used laser capture microdissection and an antidepressant-related genes microarray to analyze gene expression profiles of cells from the SGZ and from the outermost granule cell layer. Of the differentially expres...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283350b24
更新日期:2010-01-27 00:00:00