A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy.


:Rats with an experimental painful peripheral neuropathy (the chronic injury (CCI) model) display heatevoked hyperalgesia. There is now considerable evidence that nitric oxide (NO) and nitric oxide synthase are involved in the development of hyperalgesia in acute inflammatory pain states. The mechanisms responsible for hyperalgesia in chronic pain state may involve not only NO itself, but also peroxynitrite, the product of its reaction with superoxide radical, .O2- that can lead to the formation of the free radicals .OH and NO2- Under normal metabolic conditions, the cellular enzyme super oxide dismutase (SOD) provides physiological defence against superoxide radicals. TEMPOL mimics SOD and acts as a catalyst to remove the .O2- radical. The present work shows the efficacy of a stable nitroxide radical, 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPOL), against heat-evoked hyperalgesia.






Tal M




Has Abstract


1996-05-31 00:00:00












  • Transplantation of bone marrow stromal cells into the cochlea of chinchillas.

    abstract::This study aimed to evaluate the potential of bone marrow stromal cells for treatment of inner ear diseases. Autologous marrow cells labeled with Dil were implanted into the inner ear of five gentamicin-treated chinchillas. Histological analysis 3 weeks later revealed robust survival of grafted marrow cells in multipl...


    pub_type: 杂志文章


    authors: Naito Y,Nakamura T,Nakagawa T,Iguchi F,Endo T,Fujino K,Kim TS,Hiratsuka Y,Tamura T,Kanemaru S,Shimizu Y,Ito J

    更新日期:2004-01-19 00:00:00

  • Ethanol consumption and reward depend on norepinephrine in the prefrontal cortex.

    abstract::We studied the involvement of norepinephrine in the medial prefrontal cortex in the rewarding/reinforcing effects of ethanol. We evaluated the effects of norepinephrine selective depletion in the medial prefrontal cortex of C57/BL6J inbred mice that are commonly used in molecular studies and are highly susceptible to ...


    pub_type: 杂志文章


    authors: Ventura R,De Carolis D,Alcaro A,Puglisi-Allegra S

    更新日期:2006-11-27 00:00:00

  • Visuomotor adaptation during inactivation of the dentate nucleus.

    abstract::Recent experiments have suggested that the process of visuomotor adaptation depends on how a visual distortion is introduced. The cerebellum is thought to be involved in adapting to rapidly introduced visual distortions; however its role in adapting to a gradually introduced distortion is unknown. We tested adaptation...


    pub_type: 杂志文章


    authors: Robertson EM,Miall RC

    更新日期:1999-04-06 00:00:00

  • Observing the touched body magnified alters somatosensory homunculus.

    abstract::This study aimed to investigate effects of observing the own body being touched on the functional topography of the somatosensory homunculus. We used neuromagnetic source imaging to map the topography in primary somatosensory cortex (SI) while manipulating the visibility of a touched hand. Participants were either abl...


    pub_type: 杂志文章


    authors: Schaefer M,Heinze HJ,Rotte M

    更新日期:2008-06-11 00:00:00

  • Inhibition of microRNA-429 attenuates oxygen-glucose deprivation/reoxygenation-induced neuronal injury by promoting expression of GATA-binding protein 4.

    abstract::MicroRNAs (miRNAs) have been documented as critical regulators in ischemia/reperfusion-induced neuronal death. A better understanding of miRNA-mediated molecular mechanisms in ischemia/reperfusion-induced neuronal death may provide therapeutic targets for cerebral ischemia/reperfusion injury. A growing body of evidenc...


    pub_type: 杂志文章


    authors: Xiao J,Kong R,Hu J

    更新日期:2018-06-13 00:00:00

  • CO2-sensitive medullary neurons: activation by intracellular acidification.

    abstract::Bioelectric activity of CO2-sensitive, ventrolateral medullary neurons (VLN(CS)) in organotypic cultures from the obex level of newborn rats was tested during changes of the intracellular pH (pHi) measured in BCECF-AM loaded cultures. Hypercapnia (pCO2 80-100 mmHg) reduced pHi by 0.15 +/- 0.06 units and stimulated neu...


    pub_type: 杂志文章


    authors: Wiemann M,Baker RE,Bonnet U,Bingmann D

    更新日期:1998-01-05 00:00:00

  • Ultrastructural localization of P2X3 receptors in rat sensory neurons.

    abstract::We used isolated IgG antibodies selective for P2X3 receptors to study the ultrastructural distribution of these receptors in rat sensory neurons. In trigeminal ganglia, P2X3 receptor immunoreactivity occurred in small and large nerve cell bodies and their processes. Endoplasmic reticulum and Golgi apparatus were heavi...


    pub_type: 杂志文章


    authors: Llewellyn-Smith IJ,Burnstock G

    更新日期:1998-08-03 00:00:00

  • A long-range cortical network emerging with theta oscillation in a mental task.

    abstract::Human scalp EEG has demonstrated that global coherence among distant areas increases during cognitive tasks, suggesting that oscillating neural activities work to generate global neuronal assemblies for cognitive functions. The theta oscillation in a frequency range of 4-8 Hz with large amplitudes which emerges during...


    pub_type: 杂志文章


    authors: Mizuhara H,Wang LQ,Kobayashi K,Yamaguchi Y

    更新日期:2004-06-07 00:00:00

  • Glaucomatous optic neuropathy causes sensitivity loss to light offsets in the visual field.

    abstract::The functional integrity of the 'on' and 'off' neurovisual pathways has been examined in the central visual fields of normal (n = 13), glaucomatous (n = 21) and ocular hypertensive (n = 21) individuals. The detection thresholds to light increments (onsets = bright spots) and light decrements (offsets = dark spots) on ...


    pub_type: 杂志文章


    authors: Mutlukan E

    更新日期:1993-09-03 00:00:00

  • Selective death of cholinergic neurons induced by beta-methylamino-L-alanine.

    abstract::Beta-N-methylamino-L-alanine (BMAA) is a nonprotein amino acid that may be involved in neurodegenerative diseases. It is produced by a large variety of cyanobacteria and is found at high levels in the brains of Alzheimer's disease and amyotrophic lateral sclerosis patients. Although BMAA is clearly a neurotoxin, previ...


    pub_type: 杂志文章


    authors: Liu XQ,Rush T,Ciske J,Lobner D

    更新日期:2010-01-06 00:00:00

  • S100B protein stimulates calcineurin activity.

    abstract::S100B is a calcium binding protein from astrocytes that regulates protein phosphorylation by binding to substrates and protein kinases. S100B might also regulate protein phosphatases and this was investigated for protein phosphatase 2B (calcineurin). The results indicate that S100B (5-10 microM) increased the activity...


    pub_type: 杂志文章


    authors: Leal RB,Frizzo JK,Tramontina F,Fieuw-Makaroff S,Bobrovskaya L,Dunkley PR,Gonçalves CA

    更新日期:2004-02-09 00:00:00

  • Time course of electromagnetic activity associated with detection of rare events.

    abstract::The neural origins of the cortical response to rare sensory events remain poorly understood. Using simultaneous event-related potentials and magnetic resonance imaging, we investigated the anatomical profile of regional activity at various processing stages during performance of auditory and visual variants of an oddb...


    pub_type: 杂志文章


    authors: Rezaie R,Simos PG,Papanicolaou AC,Castillo EM,Moser DC,Passaro AD,Fletcher JM

    更新日期:2011-02-16 00:00:00

  • Preattentive evaluation of multiple perceptual streams in human audition.

    abstract::To analyze an auditory scene, the segregation of the input into separate streams of information is necessary. Here, the mismatch negativity (MMN) of the event-related potential was used to trace the number of simultaneously monitored streams in auditory scene analysis. Subjects passively listened to sounds belonging t...


    pub_type: 杂志文章


    authors: Nager W,Teder-Sälejärvi W,Kunze S,Münte TF

    更新日期:2003-05-06 00:00:00

  • Photochemical stroke and brain-derived neurotrophic factor (BDNF) mRNA expression.

    abstract::In situ hybridization and Northern blotting were used to study the expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain following photochemical stroke. A focal thrombotic lesion of the sensorimotor cortex was produced by intravenously injecting the light-sensitive dye rose bengal and exposing t...


    pub_type: 杂志文章


    authors: Comelli MC,Seren MS,Guidolin D,Manev RM,Favaron M,Rimland JM,Canella R,Negro A,Manev H

    更新日期:1992-06-01 00:00:00

  • Neuromagnetic auditory evoked responses after a stroke in the right temporal lobe.

    abstract::Auditory evoked magnetic fields were recorded with a 24-SQUID magnetometer on a patient with a vascular lesion in the right auditory cortex and its vicinity. The contralateral transient 100 ms response (N100m) was absent over the damaged side, with no recovery within 16 months. Responses were normal over the healthy s...


    pub_type: 杂志文章


    authors: Mäkelä JP,Hari R

    更新日期:1992-01-01 00:00:00

  • Reorganization of memory functions after human temporal lobe damage.

    abstract::Hemispheric (re-)organization of episodic memory functions after temporal lobe damage (TLD) was investigated by the intracarotid amobarbital procedure in patients suffering temporal lobe epilepsy. Memory of the speech-dominant left hemisphere was intact after right-sided TLD independent of the age at manifestation. In...


    pub_type: 杂志文章


    authors: Jokeit H,Ebner A,Holthausen H,Markowitsch HJ,Tuxhorn I

    更新日期:1996-07-08 00:00:00

  • Within- and between-channel gap detection in the human auditory cortex.

    abstract::We examined the neural correlates associated with a short gap between two identical pure tones (within-channel) and between two different tones (between-channel) in an odd-ball paradigm. Gap durations were selected such that a gap between identical tones was as discriminable as a gap between two different tones. Spati...


    pub_type: 杂志文章


    authors: Heinrich A,Alain C,Schneider BA

    更新日期:2004-09-15 00:00:00

  • Birth insult and stress interact to alter dopamine transporter binding in rat brain.

    abstract::This study investigated whether mild birth complications (C-section birth, C-section + 15 min global anoxia) interact with stress at adulthood to modulate levels of [3H]WIN 35428 binding to dopamine transporters (DAT) in rat brain. Without stress, adult C-sectioned rats showed increased DAT binding in the dorsal stria...


    pub_type: 杂志文章


    authors: El-Khodor BF,Boksa P

    更新日期:2002-02-11 00:00:00

  • Birdsong neurolinguistics: songbird context-free grammar claim is premature.

    abstract::There are remarkable behavioral, neural, and genetic similarities between song learning in songbirds and speech acquisition in human infants. Previously, we have argued that this parallel cannot be extended to the level of sentence syntax. Although birdsong can indeed have a complex structure, it lacks the combinatori...


    pub_type: 杂志文章


    authors: Beckers GJ,Bolhuis JJ,Okanoya K,Berwick RC

    更新日期:2012-02-15 00:00:00

  • Intracellular calcium signals in the surround of rat visual cortex lesions.

    abstract::Focal lesions of the visual cortex induce deafferentiation, excitotoxic cell death as well as functional reorganization in the surrounding tissue. The intracellular second messenger calcium is involved in a wide range of cellular responses including excitotoxicity and functional reorganization following cortical injur...


    pub_type: 杂志文章


    authors: Barmashenko G,Eysel UT,Mittmann T

    更新日期:2001-10-08 00:00:00

  • Attentional switching-related human EEG alpha oscillations.

    abstract::Alpha oscillations during cognitive performance have mostly been studied in memory and/or basic attention tasks. This study investigates task-related alpha power desynchronization during an attentional switching task requiring higher executive attentional control. Low 8-10 Hz and high 10-12 Hz alpha power responses ar...


    pub_type: 杂志文章


    authors: Verstraeten E,Cluydts R

    更新日期:2002-04-16 00:00:00

  • Glutamine's protection against brain damage in septic rats via increased protein oxygen-N-acetylglucosamine modification.

    abstract:OBJECTIVE:This study aimed to observe the effect of glutamine (Gln) on brain damage in septic rats and explore its possible mechanism. METHODS:Ninety-three Sprague-Dawley rats were randomly divided into five groups: sham operation group, sepsis group, Gln-treated group, quercetin/Gln-treated group, and alloxan/Gln-tre...


    pub_type: 杂志文章


    authors: Wang J,Lu X,Zheng K,Jing L

    更新日期:2021-01-18 00:00:00

  • Abnormal expression of ephrin-A5 affects brain development of congenital hypothyroidism rats.

    abstract::EphA5 and its ligand ephrin-A5 interaction can trigger synaptogenesis during early hippocampus development. We have previously reported that abnormal EphA5 expression can result in synaptogenesis disorder in congenital hypothyroidism (CH) rats. To better understand its precise molecular mechanism, we further analyzed ...


    pub_type: 杂志文章


    authors: Suo G,Shen F,Sun B,Song H,Xu M,Wu Y

    更新日期:2018-08-01 00:00:00

  • Neuronal IFN-gamma in tuberomammillary neurones.

    abstract::Neuronal interferon-gamma (N-IFN-gamma), recently isolated from the nervous system, has a molecular weight distinct from that of lymphocyte-derived IFN-gamma, but crossreacts immunologically and shares certain bioactivities with this cytokine. In the rat brain N-IFN-gamma-immunoreactive perikarya were concentrated in ...


    pub_type: 杂志文章


    authors: Bentivoglio M,Florenzano F,Peng ZC,Kristensson K

    更新日期:1994-12-20 00:00:00

  • Localization of NO synthase in rat brain by [3H]L-NG-nitro-arginine autoradiography.

    abstract::Nitric oxide (NO), a free radical gas that acts as a neural messenger, is produced from L-arginine by the enzyme nitric oxide synthase (NOS). The present study describes the autoradiographic localization throughout rat brain of the binding of [3H]L-NG-nitro-arginine ([3H]L-NOARG), a reversible NOS inhibitor, and confi...


    pub_type: 杂志文章


    authors: Burazin TC,Gundlach AL

    更新日期:1995-10-02 00:00:00

  • Left-hemisphere dominance for processing of vowels: a whole-scalp neuromagnetic study.

    abstract::Brain activation of 11 healthy right-handed subjects was studied with magnetoencephalography to estimate individual hemispheric dominance for speech sounds. The auditory stimuli comprised binaurally presented Finnish vowels, tones, and piano notes in groups of two or four stimuli. The subjects were required to detect ...


    pub_type: 临床试验,杂志文章


    authors: Gootjes L,Raij T,Salmelin R,Hari R

    更新日期:1999-09-29 00:00:00

  • Antinociceptive effect of morphine microinjections into the spinal trigeminal subnucleus oralis.

    abstract::We analysed the effects of morphine microinjections (0.2 microliter) into the subnucleus oralis (SNO), i.e. the rostral division of the spinal trigeminal nucleus, on the formalin test adapted for orofacial pain. Duration of rubbing following an injection (50 microliters) of formalin solution (1.5%) in the right upper ...


    pub_type: 杂志文章


    authors: Luccarini P,Cadet R,Saade M,Woda A

    更新日期:1995-01-26 00:00:00

  • Induced brain magnetic activities related to salient birdsong under noisy conditions.

    abstract:OBJECTIVE:Birdsong sounds are often used to inform visually-challenged people about the presence of basic infrastructures, and therefore need to be salient in noisy urban environments. How salient sounds are processed in the brain could inform us about the optimal birdsong in such environments. However, brain activity ...


    pub_type: 杂志文章


    authors: Yano H,Soeta Y

    更新日期:2021-01-13 00:00:00

  • D600, a Ca2+ antagonist, prevents stimulation of nerve regeneration by magnetic fields.

    abstract::We have found that regeneration of the rat sciatic nerve is stimulated if the rats are exposed to a 50 Hz sinusoidal magnetic field. In this study we investigated the effect of a Ca2+ antagonist, methoxyverapamil (D600) on this response. D600 was administered to the regenerating segment of the nerve via implanted osmo...


    pub_type: 杂志文章


    authors: Rusovan A,Kanje M

    更新日期:1992-09-01 00:00:00

  • Matrix metalloproteinase-9 is elevated in serum of patients with amyotrophic lateral sclerosis.

    abstract::Matrix metalloproteinase-9 (MMP-9) and its specific inhibitor, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), were analysed by enzyme-linked immunosorbent assay (ELISA) and by zymography in serum and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). In contrast to patients with ...


    pub_type: 杂志文章


    authors: Beuche W,Yushchenko M,Mäder M,Maliszewska M,Felgenhauer K,Weber F

    更新日期:2000-11-09 00:00:00