A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy.

Abstract:

:Rats with an experimental painful peripheral neuropathy (the chronic injury (CCI) model) display heatevoked hyperalgesia. There is now considerable evidence that nitric oxide (NO) and nitric oxide synthase are involved in the development of hyperalgesia in acute inflammatory pain states. The mechanisms responsible for hyperalgesia in chronic pain state may involve not only NO itself, but also peroxynitrite, the product of its reaction with superoxide radical, .O2- that can lead to the formation of the free radicals .OH and NO2- Under normal metabolic conditions, the cellular enzyme super oxide dismutase (SOD) provides physiological defence against superoxide radicals. TEMPOL mimics SOD and acts as a catalyst to remove the .O2- radical. The present work shows the efficacy of a stable nitroxide radical, 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPOL), against heat-evoked hyperalgesia.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Tal M

doi

10.1097/00001756-199605310-00010

subject

Has Abstract

pub_date

1996-05-31 00:00:00

pages

1382-4

issue

8

eissn

0959-4965

issn

1473-558X

journal_volume

7

pub_type

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