Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia.

Abstract:

:Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. Their site and mechanism of action, however, are still poorly understood. To increase our knowledge of the histaminergic system in the vestibular organs, we have investigated the expression of H1 and H3 histamine receptors in the frog and mouse semicircular canal sensory epithelia. Analysis was performed by mRNA reverse transcriptase-PCR, immunoblotting and immunocytochemistry experiments. Our data show that both frog and mouse vestibular epithelia express H1 receptors. Conversely no clear evidence for H3 receptors expression was found.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Botta L,Tritto S,Perin P,Laforenza U,Gastaldi G,Zampini V,Zucca G,Valli S,Masetto S,Valli P

doi

10.1097/WNR.0b013e3282f76151

subject

Has Abstract

pub_date

2008-03-05 00:00:00

pages

425-9

issue

4

eissn

0959-4965

issn

1473-558X

pii

00001756-200803050-00007

journal_volume

19

pub_type

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