Abstract:
:Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. Their site and mechanism of action, however, are still poorly understood. To increase our knowledge of the histaminergic system in the vestibular organs, we have investigated the expression of H1 and H3 histamine receptors in the frog and mouse semicircular canal sensory epithelia. Analysis was performed by mRNA reverse transcriptase-PCR, immunoblotting and immunocytochemistry experiments. Our data show that both frog and mouse vestibular epithelia express H1 receptors. Conversely no clear evidence for H3 receptors expression was found.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Botta L,Tritto S,Perin P,Laforenza U,Gastaldi G,Zampini V,Zucca G,Valli S,Masetto S,Valli Pdoi
10.1097/WNR.0b013e3282f76151subject
Has Abstractpub_date
2008-03-05 00:00:00pages
425-9issue
4eissn
0959-4965issn
1473-558Xpii
00001756-200803050-00007journal_volume
19pub_type
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