Abstract:
:Cultured cerebellar granule neurons were used to examine the hypothesis that NMDA or KCl-dependent Ca2+ influx activates a signaling cascade mediating transcription, translation and assembly of neurofilaments. The data indicate that 25 mM KCl and 140 microM NMDA induce neurofilament protein, mRNA, and assembly in neurites, and these require Ca2+ entry through voltage-sensitive Ca2+ channels or NMDA receptors, respectively. The CaM kinase and transcriptional inhibitors, KN-62 and actinomycin D, respectively, attenuate the stimulatory effect of Ca2+. Granular neurons are a valuable model to explore the molecular basis for transcriptional regulation of neurofilament gene expression by neuronal activity.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bui CJ,Beaman-Hall CM,Vallano MLdoi
10.1097/00001756-200311140-00013subject
Has Abstractpub_date
2003-11-14 00:00:00pages
2073-7issue
16eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
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