Abstract:
:After learning position discrimination in a T-maze water escape task, rats had either a 2 mm section of the middle cerebral artery removed bilaterally (bMCA) or they received a sham operation. Beginning on the day of surgery either total brain gangliosides (50 mg kg-1) or saline were administered daily for five days. Of the several measures of neurological function that were tested, only a temporary deficit in grasping with the front paws was observed in bMCA damaged rats. Ganglioside treatment normalized this practical function. Memory of the preoperative habit was not influenced by bMCA damage, but acquisition of a reversal of this habit was compromised. Ganglioside treatment did not influence this deficit. Acquisition of a spatial alternation strategy was influenced by neither the bMCA lesion nor the ganglioside treatment. The preservation that accompanies bMCA interruption might serve as a useful model of the functional declines that accompany stroke and frontal lobe damage.
journal_name
Neuroreportjournal_title
Neuroreportauthors
McDaniel WF,Fjordbak T,Schmidt MS,Tucker JC,Davis BKdoi
10.1097/00001756-199111000-00017subject
Has Abstractpub_date
1991-11-01 00:00:00pages
699-702issue
11eissn
0959-4965issn
1473-558Xjournal_volume
2pub_type
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