Hyperbaric oxygen promotes neural stem cell proliferation by activating vascular endothelial growth factor/extracellular signal-regulated kinase signaling after traumatic brain injury.

Abstract:

:Hyperbaric oxygen (HBO) therapy and neural stem cell (NSC) transplantation can improve traumatic brain injury (TBI) clinically. This study aimed to investigate the mechanism of HBO promoting NSC proliferation and neurological recovery after TBI. Twenty-four Sprague-Dawley rats were divided randomly into three groups: a sham group, a TBI group (constructed using Feeney's free-fall method), and an HBO-treated TBI group. Neurological function was evaluated by Neurological Severity Scores on days 1, 3, and 7, and we found that TBI-induced poor neurological function was improved by HBO. On day 7 after TBI, we observed that TBI promoted NSC proliferation, migration to the lesion area, and the levels of vascular endothelial growth factor (VEGF), VEGFR2, Raf-1, MEK1/2, and phospho-extracellular signal-regulated kinase (ERK) 1/2 protein, which were further boosted by HBO, from immunohistochemistry, immunofluorescence, and Western blot experiments. In vitro, cell injury was applied to NSCs isolated from neonatal Sprague-Dawley rats by the Cell Injury Controller II system. Moreover, data from the BrdU Kit and Western blot showed that in-vitro HBO significantly accelerated NSC proliferation and the levels of proteins related to cell cycle and the VEGF/ERK pathway after cell injury, which was suppressed by the VEGFR2 inhibitor. Taken together, this study indicated that HBO may promote NSC proliferation by activating VEGF/ERK signaling and play a crucial role in neuroprotection after TBI.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Yang Y,Wei H,Zhou X,Zhang F,Wang C

doi

10.1097/WNR.0000000000000901

subject

Has Abstract

pub_date

2017-12-13 00:00:00

pages

1232-1238

issue

18

eissn

0959-4965

issn

1473-558X

journal_volume

28

pub_type

杂志文章
  • The influence of haematocrit and blood glucose on cerebral blood flow in normal and in diabetic rats.

    abstract::Cerebral blood flow (CBF) was measured at varying haematocrit values in 8 streptozotocin-diabetic and in 7 control rats using the intracarotid 133Xe technique. A hyperbolic relationship between CBF and haematocrit was established for the individual rats in both groups. Diabetic animals showed a preserved CBF response ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199211000-00010

    authors: Knudsen GM,Tedeschi E,Jakobsen J

    更新日期:1992-11-01 00:00:00

  • Component-dependent urine responses in the rat accessory olfactory bulb.

    abstract::To investigate how pheromonal information is processed in the rat accessory olfactory bulb, we optically imaged intrinsic signals to obtain high-resolution maps of activation induced by urinary stimulation. Application of volatile components in male urine mainly induced activation in the anterior accessory olfactory b...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000239950.14954.59

    authors: Sugai T,Yoshimura H,Kato N,Onoda N

    更新日期:2006-11-06 00:00:00

  • Guanine nucleotides block agonist-driven 45Ca2+ influx in chick embryo retinal explants.

    abstract::AMPA (EC50 = 1.0 x 10(-6) M) and NMDA (EC50 = 1.3 x 10(-4) M) trigger 45Ca2+ influx in 13-day chick embryonic retinal explants. This agonist-driven cationic flux is specifically inhibited by typical competitive antagonists, such as 6,7-dinitroquinoxaline-2,3-dione (DNQX) and 2-amino-7-phosphonoheptanoate (AP7), respec...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200007140-00047

    authors: Burgos JS,Barat A,Ramírez G

    更新日期:2000-07-14 00:00:00

  • Nogo-66 receptor at the gap junctions between pituicytes of the rat.

    abstract::Nogo-66 receptor was first identified in neurons. Recently, it was demonstrated in glial cells as well. Our previous study on the expression of Nogo-66 receptor in the cerebellum of the rat surprisingly found its location at the glial gap junctions. Here, we present our study on Nogo-66 receptor in the rat posterior p...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200604240-00010

    authors: Wang YZ,Liu YY,Liu JP,You SW,Ju G

    更新日期:2006-04-24 00:00:00

  • Schwann cells induce neuronal differentiation of bone marrow stromal cells.

    abstract::Bone marrow stromal cells are multipotent stem cells that have the potential to differentiate into bone, cartilage, fat and muscle. Recently, bone marrow stromal cells have been shown to have the capacity to differentiate into neurons under specific experimental conditions, using chemical factors. We now describe how ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200504040-00017

    authors: Zurita M,Vaquero J,Oya S,Miguel M

    更新日期:2005-04-04 00:00:00

  • Brain activity during expectancy of emotional stimuli: an fMRI study.

    abstract::We studied the neural activation associated with the expectancy of emotional stimuli using whole brain fMRI. Fifteen healthy subjects underwent fMRI scanning during which they performed a warned reaction task using emotional pictures carrying pleasant, unpleasant, or neutral content. The task involved an expected or u...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200301200-00010

    authors: Ueda K,Okamoto Y,Okada G,Yamashita H,Hori T,Yamawaki S

    更新日期:2003-01-20 00:00:00

  • Endogenous radial glial cells support regenerating axons after spinal cord transection.

    abstract::During the development of central nervous system, radial glial cells support target-specific neuronal migration. We recently reported that after implantation of chitosan channels with complete spinal cord transection, the tissue bridging the spinal cord stumps contained axons and radial glial cells. The purpose of thi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32833d9695

    authors: Nomura H,Kim H,Mothe A,Zahir T,Kulbatski I,Morshead CM,Shoichet MS,Tator CH

    更新日期:2010-09-15 00:00:00

  • Effect of erythropoietin on Fas/FasL expression in brain tissues of neonatal rats with hypoxic-ischemic brain damage.

    abstract::Hypoxic-ischemic brain damage (HIBD) occurs due to intrauterine hypoxia ischemia influencing the energy supply for fetal brain cells, which affects the metabolism of the brain to make the brain suffer a severe damage. Erythropoietin (EPO), which regulates hemacytopoiesis, is a kind of cytokine. EPO is sensitive to hyp...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001194

    authors: Huang R,Zhang J,Ren C,Zhang X,Gu L,Dong Y,Zhang J,Zhang J

    更新日期:2019-03-06 00:00:00

  • Delayed production of nitric oxide contributes to NMDA-mediated neuronal damage.

    abstract::Exposure of primary murine cortical neuron cultures to N-methyl-D-aspartate (NMDA) resulted in neuronal death as evidenced by release of lactate dehydrogenase (LDH) into the media. The addition of N-nitro-L-arginine (N-Arg) protected the neurons from death in a concentration-dependent manner when added after the NMDA,...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199305000-00026

    authors: Reif DW

    更新日期:1993-05-01 00:00:00

  • Increased levels of TrkA in the regenerating retinal ganglion cells of fish.

    abstract::Retinal ganglion cells of the fish have the spontaneous capacity to regenerate after nerve crush, a phenomenon known to be facilitated by nerve growth factor (NGF). We have studied the high-affinity NGF receptor TrkA, during the regeneration of the tench (Tinca tinca L.) optic nerve, using immunocytochemical technique...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199810260-00014

    authors: Vecino E,Caminos E,Becker E,Rudkin BB,Evan GI,Martín-Zanca D

    更新日期:1998-10-26 00:00:00

  • Age-related changes in serum and brain levels of androgens in male Brown Norway rats.

    abstract::Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum leve...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328331f968

    authors: Rosario ER,Chang L,Beckett TL,Carroll JC,Paul Murphy M,Stanczyk FZ,Pike CJ

    更新日期:2009-11-25 00:00:00

  • Sound perception affected by nonlinear variation of accuracy in memory trace.

    abstract::The mismatch negativity (MMN) reflects the neural representation of the acoustic environment stored in sensory memory. The short phase of sensory memory corresponds to the temporal window of integration (TWI) which integrates the neighboring sounds into a unitary event. We measured the magnetic MMN (MMNm) and the disc...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Yabe H,Asai R,Hiruma T,Sutoh T,Koyama S,Kakigi R,Tervaniemi M,Kaneko S

    更新日期:2004-12-22 00:00:00

  • Chronic ethanol exposure reduces the expression of NCX3 in the hippocampus of male C57BL/6 mice.

    abstract::Chronic ethanol (EtOH) exposure can cause intracellular Ca overload by stimulating calcium channel receptors and trigger apoptosis of neurons. NCX3 may play a cytoprotective role in intracellular Ca excretion. In this study, the effect of EtOH on NCX3 was analyzed by observing NCX3 expression in the hippocampus of chr...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001214

    authors: Wang C,Wang X,Li Y,Xia Z,Liu Y,Yu H,Xu G,Wu X,Zhao R,Zhang G

    更新日期:2019-04-10 00:00:00

  • Induction of NG108-15 cells differentiation by human bone marrow stromal cells.

    abstract::The survival and differentiation of neuronal cells is dependent on factors such as neurotrophins, cytokines and components of extracellular matrix. Bone marrow stromal cells have been shown to support the growth and differentiation of neuroblastoma cells. In an attempt to study the effects of bone marrow stromal cells...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199805110-00021

    authors: Ho SH,So LH,Lai KO,Ip NY,Leung MF

    更新日期:1998-05-11 00:00:00

  • Functional neuroimaging of attention in the auditory modality.

    abstract::Previous functional neuroimaging studies of attention have emphasized the visual modality. We developed an auditory version of the continuous performance test (CPT) that included simple, focused and divided attention conditions. Positron emission tomographic (PET) scans were acquired during CPT performance in normal y...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199801050-00024

    authors: Benedict RH,Lockwood AH,Shucard JL,Shucard DW,Wack D,Murphy BW

    更新日期:1998-01-05 00:00:00

  • Withdrawal from a single exposure to cocaine increases 5-HT2A receptor and G protein function.

    abstract::We previously reported that withdrawal from chronic cocaine produces supersensitivity of serotonin 2A receptors. We report here the minimum cocaine exposure necessary to produce withdrawal-associated increases in serotonin 2A receptor signaling in the frontal cortex. Rats withdrawn from cocaine treatments of 1, 3 or 7...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000246324.43567.55

    authors: Carrasco GA,Battaglia G

    更新日期:2007-01-08 00:00:00

  • Brain stem energy metabolism response to acute hypoxia in anaesthetized rats: a 31P NMR study.

    abstract::Mammals react to acute hypoxia with an initial augmentation and a secondary depression of the respiratory rhythm generated by brain stem neuronal networks. To investigate the cytosolic level of energy rich phosphorus metabolites during these responses, we developed 31P nuclear magnetic resonance spectroscopy of the br...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Piérard C,Champagnat J,Denavit-Saubie M,Gillet B,Beloeil JC,Guezennec CY,Barrère B,Pérès M

    更新日期:1995-12-29 00:00:00

  • Effects of repeated amphetamine treatment on the locomotor activity of the dopamine D1A-deficient mouse.

    abstract::The role of dopamine D1A receptors in mediating amphetamine-induced sensitization was investigated using the D1A-deficient mouse. During the drug pre-exposure phase, D1A-deficient and control mice were injected for five consecutive days with saline or amphetamine (2 mg/kg, i.p.). Locomotor activity was measured on the...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199707280-00021

    authors: Crawford CA,Drago J,Watson JB,Levine MS

    更新日期:1997-07-28 00:00:00

  • A long-range cortical network emerging with theta oscillation in a mental task.

    abstract::Human scalp EEG has demonstrated that global coherence among distant areas increases during cognitive tasks, suggesting that oscillating neural activities work to generate global neuronal assemblies for cognitive functions. The theta oscillation in a frequency range of 4-8 Hz with large amplitudes which emerges during...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000126755.09715.b3

    authors: Mizuhara H,Wang LQ,Kobayashi K,Yamaguchi Y

    更新日期:2004-06-07 00:00:00

  • Intracellular calcium signals in the surround of rat visual cortex lesions.

    abstract::Focal lesions of the visual cortex induce deafferentiation, excitotoxic cell death as well as functional reorganization in the surrounding tissue. The intracellular second messenger calcium is involved in a wide range of cellular responses including excitotoxicity and functional reorganization following cortical injur...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200110080-00009

    authors: Barmashenko G,Eysel UT,Mittmann T

    更新日期:2001-10-08 00:00:00

  • Differential distributions of parvalbumin-positive interneurons in the sulci and gyri of the adult ferret cerebral cortex.

    abstract::Although accumulating evidence suggests that there are significant anatomical and histological differences between the sulci and gyri of the cerebral cortex, whether there is a difference in the distribution of interneurons between the two cortical regions remains largely unknown. In this study, we systematically comp...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001309

    authors: Gao JT,Liu Y,Gong D,Feng XM,Wan P,Luo XF,Zhu WH,Hou JC,Lv SJ

    更新日期:2019-10-16 00:00:00

  • Functional recruitment of red blood cells to rat brain microcirculation accompanying increased neuronal activity in cerebellar cortex.

    abstract::Scanning laser-Doppler flowmetry (SLDF) combines laser-Doppler flowmetry and laser scanning to provide images of cerebral blood flow (CBF) with high spatial and temporal resolution. We investigated the contribution of single vascular elements to the local increase of CBF accompanying increased neuronal activity in hal...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199911080-00002

    authors: Akgören N,Lauritzen M

    更新日期:1999-11-08 00:00:00

  • Hypoxia-induced decrease of brain acetylcholine release detected by microdialysis.

    abstract::The in-vivo extracellular release of acetylcholine (ACh) from the striatum of rats was measured by intracerebral microdialysis. The ACh levels were first estimated under normoxic conditions, after which the rats were exposed to either 10% or 5% oxygen for 1 h. The average ACh content was 2.9 pmol/20 min. During hypoxi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199011000-00005

    authors: Chleide E,Ishikawa K

    更新日期:1990-11-01 00:00:00

  • D600, a Ca2+ antagonist, prevents stimulation of nerve regeneration by magnetic fields.

    abstract::We have found that regeneration of the rat sciatic nerve is stimulated if the rats are exposed to a 50 Hz sinusoidal magnetic field. In this study we investigated the effect of a Ca2+ antagonist, methoxyverapamil (D600) on this response. D600 was administered to the regenerating segment of the nerve via implanted osmo...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199209000-00023

    authors: Rusovan A,Kanje M

    更新日期:1992-09-01 00:00:00

  • Neural manifestation of cognitive and precognitive mismatch detection in early infancy.

    abstract::We recorded event-related potentials (ERPs) in 2-month-old infants in two different states of alertness: awake and asleep. Syllables varying in vowel duration (long vs short) were presented in an oddball paradigm, known to elicit a mismatch brain response. ERPs of both groups showed a mismatch response reflected in a ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200207190-00006

    authors: Friederici AD,Friedrich M,Weber C

    更新日期:2002-07-19 00:00:00

  • Amino alcohol modulation of hippocampal acetylcholine release.

    abstract::The synthesis and release of 3H-acetylcholine was measured in hippocampal slices of adult rat brain following acute in vitro exposure to ethanolamine. Evoked release of 3H-acetylcholine was elevated by 60-70% but 3H-acetylcholine synthesis was unaffected. Other amino alcohols were also found to significantly increase ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199205000-00012

    authors: Bostwick JR,Abbe R,Sun J,Appel SH

    更新日期:1992-05-01 00:00:00

  • Functional neuroanatomy of speech processing within the temporal cortex.

    abstract::The phonemic structure of the maternal language determines the way of perceiving speech signals. A typical example is that native Japanese listeners map two English phonemes, /r/ and /l/, onto the same /R/. This perceptual assimilation of speech sounds has been associated with the left and/or right posterior perisylvi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f03f39

    authors: Hara NF,Nakamura K,Kuroki C,Takayama Y,Ogawa S

    更新日期:2007-10-08 00:00:00

  • Age-dependent changes in distribution of P3a/P3b amplitude and thickness of the cerebral cortex.

    abstract::With increasing age, the electrophysiological event-related potentials P3a/P3b tend to get a more frontal maximum. The cognitive significance of this so-called frontal shift is not known, but hypotheses have focused on changes in the integrity of the frontal lobes. The aim of the present study was to test how the thic...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000177011.44602.17

    authors: Fjell AM,Walhovd KB,Reinvang I

    更新日期:2005-09-08 00:00:00

  • Vasopressin facilitates its own release within the rat supraoptic nucleus in vivo.

    abstract::A combined microdialysis/microinfusion technique was used to investigate whether arginine vasopressin (AVP) is involved in the regulation of its own release into the extracellular fluid of the supraoptic nucleus in vivo. While intranuclear neuropeptide release was monitored, 0.33 microliter of either vehicle, lysine v...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199406020-00005

    authors: Wotjak CT,Ludwig M,Landgraf R

    更新日期:1994-06-02 00:00:00

  • Rat strain differences to fluoxetine in striatal Fos-like proteins.

    abstract::Humans afflicted with mood disorders respond differently to antidepressant drug therapy. Different responses to psychoactive drugs are also observed in rats, and specific strains exhibit substantial differences in gene expression following synaptic activity. We examined the effects of fluoxetine on the induction of Fo...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200212200-00018

    authors: Horowitz JM,Hallas BH,Torres G

    更新日期:2002-12-20 00:00:00