Abstract:
:The in-vivo extracellular release of acetylcholine (ACh) from the striatum of rats was measured by intracerebral microdialysis. The ACh levels were first estimated under normoxic conditions, after which the rats were exposed to either 10% or 5% oxygen for 1 h. The average ACh content was 2.9 pmol/20 min. During hypoxia, the ACh levels were decreased to 62% and 44% of the control value with 10% and 5% oxygen, respectively. The data confirmed the high sensitivity of the striatal cholinergic system to hypoxia. The results are discussed in relation to the hypothesis that disruption of Ca2+ homeostasis may underlie the hypoxia-induced deficits in ACh release.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Chleide E,Ishikawa Kdoi
10.1097/00001756-199011000-00005subject
Has Abstractpub_date
1990-11-01 00:00:00pages
197-9issue
3-4eissn
0959-4965issn
1473-558Xjournal_volume
1pub_type
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