Abstract:
:The aim of this study was to investigate whether the DNA methylation pattern within the alpha synuclein promoter region is altered in intoxicated and early abstinence patients with alcoholism undergoing alcohol withdrawal. We observed a significant increase of the alpha synuclein promoter DNA methylation in patients with alcoholism which was significantly associated with their elevated homocysteine levels. No significant differences of the promoter DNA methylation within a control gene (presenilin-1) in alcoholics and controls were found. The present results hint to a gene specific DNA promoter hypermethylation within the alpha synuclein gene. Since hypermethylation of DNA is an important epigenetic factor in the down regulation of gene expression and since alpha synuclein has been linked to craving these findings may explain the reduced value of craving under alcohol drinking conditions.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bönsch D,Lenz B,Kornhuber J,Bleich Sdoi
10.1097/00001756-200502080-00020subject
Has Abstractpub_date
2005-02-08 00:00:00pages
167-70issue
2eissn
0959-4965issn
1473-558Xpii
00001756-200502080-00020journal_volume
16pub_type
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