DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism.

Abstract:

:The aim of this study was to investigate whether the DNA methylation pattern within the alpha synuclein promoter region is altered in intoxicated and early abstinence patients with alcoholism undergoing alcohol withdrawal. We observed a significant increase of the alpha synuclein promoter DNA methylation in patients with alcoholism which was significantly associated with their elevated homocysteine levels. No significant differences of the promoter DNA methylation within a control gene (presenilin-1) in alcoholics and controls were found. The present results hint to a gene specific DNA promoter hypermethylation within the alpha synuclein gene. Since hypermethylation of DNA is an important epigenetic factor in the down regulation of gene expression and since alpha synuclein has been linked to craving these findings may explain the reduced value of craving under alcohol drinking conditions.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Bönsch D,Lenz B,Kornhuber J,Bleich S

doi

10.1097/00001756-200502080-00020

subject

Has Abstract

pub_date

2005-02-08 00:00:00

pages

167-70

issue

2

eissn

0959-4965

issn

1473-558X

pii

00001756-200502080-00020

journal_volume

16

pub_type

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