Changes occur in the ability to promote axonal regeneration as the post-injury period increases.

abstract：:Using NADPH-diaphorase (NADPH-d) histochemistry, the expression of nitric oxide synthase (NOS) was studied in the rat brain 1 week after kainate-induced status epilepticus. Major changes were observed in the hippocampi of epileptic animals, especially a loss of NADPH-d positive fibres in the periphery of degenerative ...

journal_title：Neuroreport

authors： Lerner-Natoli M,de Bock F,Bockaert J,Rondouin G

更新日期：1994-12-20 00:00:00

abstract：:In mammals, cytosine methylation is important for the regulation of gene expression and chromatin structure. Recently, we have found evidence indicating that the maintained DNA methyltransferase activity is critical for neuronal cell differentiation. In the present study, we have investigated the effect of the DNA met...

journal_title：Neuroreport

authors： Persengiev SP,Kilpatrick DL

更新日期：1997-07-07 00:00:00

abstract：:DNA methylation is important for controlling gene expression and is catalyzed by DNA methyltransferase (Dnmt1) an enzyme abundant in brain. We recently demonstrated that mice expressing reduced levels of Dnmt1 are protected from cerebral ischemia. Here, we used the cre/loxP system to produce conditional mutants that l...

journal_title：Neuroreport

authors： Endres M,Fan G,Meisel A,Dirnagl U,Jaenisch R

更新日期：2001-12-04 00:00:00

abstract：:The mammalian neocortex is composed of six major layers of neurons. Each group of neurons in the cortical layers has distinct characteristics based on the expression of specific genes and connectivity patterns of neural circuits. Neuronal subtype transition and regional identity acquisition are established by temporal...

journal_title：Neuroreport

authors： Lee SE,Hwang S,Ahn SG,D'Arcangelo G,Lee GH

更新日期：2020-07-10 00:00:00

abstract：:The discovery of mis-sense mutations linking the presenilin-1 (PS-1) gene on chromosome 14 to Alzheimer's disease (AD) has lead to a thorough investigation of this locus. The PS-1 gene contains a polymorphism creating two alleles. The most common allele, allele 1, has been linked with late-onset AD. Given the clinical...

journal_title：Neuroreport

authors： Singleton AB,Lamb H,Leake A,McKeith IG,Ince PG,Perry RH,Morris CM

更新日期：1997-11-10 00:00:00

abstract：:We used isolated IgG antibodies selective for P2X3 receptors to study the ultrastructural distribution of these receptors in rat sensory neurons. In trigeminal ganglia, P2X3 receptor immunoreactivity occurred in small and large nerve cell bodies and their processes. Endoplasmic reticulum and Golgi apparatus were heavi...

journal_title：Neuroreport

authors： Llewellyn-Smith IJ,Burnstock G

更新日期：1998-08-03 00:00:00

abstract：:The phonemic structure of the maternal language determines the way of perceiving speech signals. A typical example is that native Japanese listeners map two English phonemes, /r/ and /l/, onto the same /R/. This perceptual assimilation of speech sounds has been associated with the left and/or right posterior perisylvi...

journal_title：Neuroreport

authors： Hara NF,Nakamura K,Kuroki C,Takayama Y,Ogawa S

更新日期：2007-10-08 00:00:00

abstract：:The aim of this study was to reveal a potential effect of emotion on cognitive control in the implicit memory task with emotionally neutral and unpleasant words in healthy controls and patients with schizophrenia using a 3.0 T functional MRI (fMRI). A total of 15 patients with schizophrenia and 15 healthy controls und...

journal_title：Neuroreport

authors： Kim GW,Yang JC,Jeong GW

更新日期：2015-08-05 00:00:00

abstract：:It is assumed that in esotropic cats the behavioural suppression of the nasal field reflects inhibition of the input conveyed through the temporal retinal afferents of the strabismic eye. We hypothesized that inhibition underlying the field defect might be actively operated by interocular competitive mechanisms. If so...

journal_title：Neuroreport

authors： Di Stefano M,Gargini C

更新日期：1995-06-19 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) was used in 17 normal individuals to modulate vestibulo-ocular reflex (VOR) and self-motion perception rotational thresholds. The electrodes were applied over the temporoparietal junction bilaterally. Both vestibular nystagmic and perceptual thresholds were increased duri...

journal_title：Neuroreport

authors： Kyriakareli A,Cousins S,Pettorossi VE,Bronstein AM

更新日期：2013-10-02 00:00:00

abstract：:The rat synaptosomal membrane antigen D3, which has been studied for more than 20 years since its first demonstration as a brain-specific protein, was shown to bind monoclonal antibodies to SNAP-25, a presynaptic plasma membrane-associated protein. In addition to SNAP-25, anti-D3 antiserum also precipitated two polype...

journal_title：Neuroreport

authors： Jørgensen OS

更新日期：1995-12-29 00:00:00

abstract：:To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case-control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan...

journal_title：Neuroreport

authors： Funayama M,Li Y,Tomiyama H,Yoshino H,Imamichi Y,Yamamoto M,Murata M,Toda T,Mizuno Y,Hattori N

更新日期：2007-02-12 00:00:00

abstract：:We investigated the cardiovascular effects of bilateral microinjection of antisense oligodeoxynucleotides (oligos) into the nucleus tractus solitarii (NTS) to neuronal nitric oxide synthase (nNOS) to suppress the expression of nNOS molecular biologically. In urethane-anesthetized, paralyzed Wistar-Kyoto rats, bilatera...

journal_title：Neuroreport

authors： Maeda M,Hirano H,Kudo H,Doi Y,Higashi K,Fujimoto S

更新日期：1999-06-23 00:00:00

abstract：:EphA5 and its ligand ephrin-A5 interaction can trigger synaptogenesis during early hippocampus development. We have previously reported that abnormal EphA5 expression can result in synaptogenesis disorder in congenital hypothyroidism (CH) rats. To better understand its precise molecular mechanism, we further analyzed ...

journal_title：Neuroreport

authors： Suo G,Shen F,Sun B,Song H,Xu M,Wu Y

更新日期：2018-08-01 00:00:00

abstract：:Mitochondrial dysfunction and oxidative stress are implicated in the pathological changes observed in the diabetic central nervous system. In this study, using the streptozotocin-induced diabetic rat model we document for the first time the over-expression of a mitochondrial specific stress protein (chaperonin 60) in ...

journal_title：Neuroreport

authors： Yuan J,Young BJ,Martinus RD

更新日期：2006-02-27 00:00:00

abstract：:The auditory-evoked potential's N1 component of the scalp electroencephalogram is a well-established measure of electrical brain activity. The N1 reflects basic auditory processing and is modulated by auditory experience, for instance, by musical training. Here, we explore a possible correlation between the auditory N...

journal_title：Neuroreport

authors： Liem F,Zaehle T,Burkhard A,Jäncke L,Meyer M

更新日期：2012-12-05 00:00:00

abstract：:A simple but effective method has been devised to explore backward masking in cutaneous sensation. In this method a weak electrical shock to the palm (test stimulus) is followed by a stronger shock to the same site (masking stimulus). By combining this stimulation strategy with a choice reaction time paradigm, it has ...

journal_title：Neuroreport

authors： MacIntyre NJ,McComas AJ

更新日期：1996-06-17 00:00:00

abstract：:Immunohistochemistry for calcitonin gene-related peptide (CGRP) was performed on the dorsal root ganglion (DRG) and spinal cord in wildtype and knockout mice for Brn-3a. CGRP-immunoreactive (-IR) neurons were abundant in the DRG of wildtype, heterozygous and knockout mice. Cell size analysis revealed that CGRP-IR neur...

journal_title：Neuroreport

authors： Ichikawa H,Yamaai T,Mo Z,Xiang M,Sugimoto T

更新日期：2002-03-25 00:00:00

abstract：:Selective degeneration of hypothalamic orexin neurons, a hallmark of pathology in narcolepsy patients, is in part reproduced in hypothalamic slice cultures by application of an endogenous excitotoxin quinolinic acid. Depolarized membrane potential may be responsible for the vulnerability of orexin neurons to excitotox...

journal_title：Neuroreport

authors： Katsuki H,Akaike A

更新日期：2005-08-01 00:00:00

abstract：:It remains an open question whether the amplitude of N400 reflects combinatory postlexical semantic integration processing. To examine the issue, we repeatedly presented strictly simplified, N400-eliciting three-word structures for seven times, mixed with their plausible counterparts, followed immediately by a much mo...

journal_title：Neuroreport

authors： Huang Y,Jiang M,Guo Q,Yang FG

更新日期：2018-11-07 00:00:00

abstract：:Olfactory cues can elicit intense emotional responses. This study used fMRI in male common marmoset monkeys to identify brain areas associated with sexual arousal in response to odors of ovulating female monkeys. Under light anesthesia, monkeys were secured in a specially designed restrainer and positioned in a 9.4 T ...

journal_title：Neuroreport

authors： Ferris CF,Snowdon CT,King JA,Duong TQ,Ziegler TE,Ugurbil K,Ludwig R,Schultz-Darken NJ,Wu Z,Olson DP,Sullivan JM Jr,Tannenbaum PL,Vaughan JT

更新日期：2001-07-20 00:00:00

abstract：:In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy. We demonstrate that IGF-I and its receptor are prefe...

journal_title：Neuroreport

authors： Craner MJ,Klein JP,Black JA,Waxman SG

更新日期：2002-09-16 00:00:00

abstract：:Fragile X syndrome is a neurodevelopmental disorder caused by a trinucleotide (CGG) hyperexpansion in the FMR1 gene, functionally silencing transcription of the fragile X mental retardation protein (FMRP). This disorder is characterized by impaired cognition, communication, and social behavior. The aim of this study w...

journal_title：Neuroreport

authors： Reynolds CD,Nolan SO,Jefferson T,Lugo JN

更新日期：2016-12-14 00:00:00

abstract：:Two monkeys were trained in a delayed sequential motor task in which the time interval between events and the delay duration were either fixed or variable. Single-unit neuronal activity was recorded in the pre-supplementary motor area (pre-SMA). During the delay, we observed a gradual increase in activity (build-up pa...

journal_title：Neuroreport

authors： Akkal D,Escola L,Bioulac B,Burbaud P

更新日期：2004-06-07 00:00:00

abstract：:We report an event-related potential study investigating the neural basis of interference and facilitation in the picture-word interference paradigm with immediate overt naming. We used the high temporal resolution of the electrophysiological response to dissociate general and specific interference processes, by compa...

journal_title：Neuroreport

authors： Hirschfeld G,Jansma B,Bölte J,Zwitserlood P

更新日期：2008-08-06 00:00:00

abstract：:The functional integrity of the 'on' and 'off' neurovisual pathways has been examined in the central visual fields of normal (n = 13), glaucomatous (n = 21) and ocular hypertensive (n = 21) individuals. The detection thresholds to light increments (onsets = bright spots) and light decrements (offsets = dark spots) on ...

journal_title：Neuroreport

authors： Mutlukan E

更新日期：1993-09-03 00:00:00

abstract：:Changes in the regulation, formation, and gating of connexin-based gap junction channels occur in various disorders. It has been shown that H and Ca are involved in the regulation of gap junctional communication. Ischemia-induced intracellular acidification and Ca overload lead to closure of gap junctions and inhibit ...

journal_title：Neuroreport

authors： Kucheryavykh LY,Benedikt J,Cubano LA,Skatchkov SN,Bukauskas FF,Kucheryavykh YV

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:Birdsong sounds are often used to inform visually-challenged people about the presence of basic infrastructures, and therefore need to be salient in noisy urban environments. How salient sounds are processed in the brain could inform us about the optimal birdsong in such environments. However, brain activity ...

journal_title：Neuroreport

authors： Yano H,Soeta Y

更新日期：2021-01-13 00:00:00

abstract：:This study investigated whether mild birth complications (C-section birth, C-section + 15 min global anoxia) interact with stress at adulthood to modulate levels of [3H]WIN 35428 binding to dopamine transporters (DAT) in rat brain. Without stress, adult C-sectioned rats showed increased DAT binding in the dorsal stria...

journal_title：Neuroreport

authors： El-Khodor BF,Boksa P

更新日期：2002-02-11 00:00:00

abstract：:Astrogliosis is an important component of the response to injury of the central nervous system (CNS). The Id family of helix-loop-helix (HLH) transcription factors has been implicated in the regulation of cellular differentiation in several different lineages and may contribute to the regulation of astrogliosis. We ex...

journal_title：Neuroreport

authors： Andres-Barquin PJ,Hernandez MC,Israel MA

更新日期：1998-12-21 00:00:00