Abstract:
:We investigated the cardiovascular effects of bilateral microinjection of antisense oligodeoxynucleotides (oligos) into the nucleus tractus solitarii (NTS) to neuronal nitric oxide synthase (nNOS) to suppress the expression of nNOS molecular biologically. In urethane-anesthetized, paralyzed Wistar-Kyoto rats, bilateral microinjection of nNOS antisense oligos (20 pmol in a 50nl volume) into the NTS produced a significant increase in mean arterial blood pressure at 30-60min after injection, compared with rats injected with nNOS sense or scrambled oligos. Immunohistochemical study demonstrated that nNOS immunoreactivity in the rat NTS was suppressed by nNOS antisense oligos. These results indicate that suppression of the nNOS gene using antisense in the NTS increases blood pressure.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Maeda M,Hirano H,Kudo H,Doi Y,Higashi K,Fujimoto Sdoi
10.1097/00001756-199906230-00030subject
Has Abstractpub_date
1999-06-23 00:00:00pages
1957-60issue
9eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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