Abstract:
:The aim of this study was to show that Cl(-)-dependent excitotoxicity, with its characteristic cell swelling, involves actual water influx into the intracellular compartment. Taking advantage of the Ca2+ omission paradigm of Cl(-)-dependent excitotoxicity, in the chick embryonic neural retina ex vivo, which is associated with toxicity levels (lactate dehydrogenase (LDH) release) considerably higher than those seen after simple exposure of the retinas to glutamate agonists, we have demonstrated that an intracellular water intake of 4.2 microl into retinal cells is associated with 13.3% total retinal LDH release. The fact that mannitol blocks both water inflow and LDH release appears to link both events from a pathogenic point of view.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Burgos JS,Barat A,Ramirez Gdoi
10.1097/00001756-200011270-00037subject
Has Abstractpub_date
2000-11-27 00:00:00pages
3779-82issue
17eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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