Laminar-selective noradrenergic and serotoninergic modulation includes spinoparabrachial cells after inflammation.

Abstract:

:We evaluated the effects of chemical lesions on hindpaw inflammation-induced Fos protein expression in spinoparabrachial neurons that were retrogradely labeled by Fluoro-Gold. The descending serotoninergic and noradrenergic pathways were destroyed by the selective neurotoxins, 5,7-DHT and DSP-4, respectively. After 5,7-DHT treatment there was a significant increase in double-labeled neurons only in the lateral reticulated neck of the dorsal horn 24h after inflammation compared with vehicle-injected controls. In contrast, the DSP-4 treatment resulted in a more robust increase in double-labeled neurons in the ipsilateral superficial dorsal horn than in the neck of the dorsal horn. These results indicate that after inflammation the enhanced modulation from descending serotoninergic and noradrenergic pathways targets supraspinally projecting neurons to dampen increased ascending nociceptive input. Further, these pathways differentially suppress the responses of spinoparabrachial neurons in the deep and superficial dorsal horn.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Wei F,Dubner R,Ren K

doi

10.1097/00001756-199906030-00024

subject

Has Abstract

pub_date

1999-06-03 00:00:00

pages

1757-61

issue

8

eissn

0959-4965

issn

1473-558X

journal_volume

10

pub_type

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