Abstract:
:As the most numerous cell type in the brain, astrocytes are coupled via gap junction channels. It is believed that communication among astrocytes is normally regulated by extracellular ions, neurotransmitters and neuromodulators. However, the level of astrocytic coupling is altered in abnormal conditions such as stroke, brain trauma and Alzheimer's disease. A well established human progenitor cell line, NT2/D1, has been previously differentiated into pure neuronal cultures. In the current study, for the first time, we report the differentiation of NT2/D1 cells into astrocytes, which express connexin43 and are coupled via gap junctions. Thus, human NT2/D1 cells are not merely committed neuronal progenitors but, similar to the embryonal stem cells, they can give rise to both lineages.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bani-Yaghoub M,Felker JM,Naus CCdoi
10.1097/00001756-199912160-00022subject
Has Abstractpub_date
1999-12-16 00:00:00pages
3843-6issue
18eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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