Abstract:
:The perifornical-lateral hypothalamic area is implicated in regulating waking and paradoxical sleep. The blockade of GABAA receptors by iontophoretic applications of bicuculline (or gabazine) into the perifornical-lateral hypothalamic area induced a continuous quiet waking state associated to a robust muscle tone in head-restrained rats. During the effects, sleep was totally suppressed. In rats killed at the end of a 90 min ejection of bicuculline, Fos expression was induced in approximately 28% of the neurons immunoreactive for hypocretin and in approximately 3% of the neurons immunostained for melanin-concentrating hormone within the ejection site. These results suggest that neurons containing melanin-concentrating hormone are not active during waking and that the lack of a potent GABAergic influence during waking is consistent with their role in sleep regulation.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Goutagny R,Luppi PH,Salvert D,Gervasoni D,Fort Pdoi
10.1097/00001756-200507130-00008subject
Has Abstractpub_date
2005-07-13 00:00:00pages
1069-73issue
10eissn
0959-4965issn
1473-558Xpii
00001756-200507130-00008journal_volume
16pub_type
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