Abstract:
:The role of dopaminergic pathways in the retina in controlling the functional state of the pineal was investigated. Dopaminergic agents were injected into the eyes of dark-adapted chickens which were maintained in the dark. Changes in the activity of N-acetyltransferase (NAT) in the retina and pineal were then monitored. Injection of the non-specific dopamine agonist 6,7-ADTN depressed retinal and pineal NAT. The D1-specific agonist SKF38393 did not affect retinal NAT but depressed pineal NAT. In contrast, quinpirole, a D2-specific agonist, depressed retinal NAT, but did not depress pineal NAT. Thus, D1- rather than D2-dopaminergic pathways in the retina are involved in the retinal circuit which control pineal function.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Morgan IG,Boelen MK,Miethke Pdoi
10.1097/00001756-199502000-00010subject
Has Abstractpub_date
1995-02-15 00:00:00pages
446-8issue
3eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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