Luciferase expression controlled by a viral gene promoter in a mammalian circadian pacemaker.

abstract：:Oscillatory activity is a ubiquitous property of brain signals, and yet relatively few studies have investigated how the phase of such ongoing oscillations affects our cognition. One of the main findings in this field is that the phase of electroencephalography (EEG) in the alpha band can affect perception of millisec...

journal_title：Neuroreport

authors： Jalali A,Tata MS,Gruber AJ,Luczak A

更新日期：2019-04-10 00:00:00

abstract：:Cortical auditory categorization was assessed in 2-month-old infants at genetic risk for dyslexia and controls. Manipulated /bAk/ and /dAk/ speech stimuli were used as frequently presented standards. The neuroelectric brain responses of the control infants were highly sensitive to the phoneme boundary that separated t...

journal_title：Neuroreport

authors： van Leeuwen T,Been P,van Herten M,Zwarts F,Maassen B,van der Leij A

更新日期：2007-06-11 00:00:00

abstract：:We investigated the brain mechanisms enabling one automatically discriminate phoneme category irrespective of the large inter-speaker variability in the acoustic features of the voices. For this purpose, subjects were presented with 450 different speech stimuli, each uttered by a different speaker, belonging to three ...

journal_title：Neuroreport

authors： Shestakova A,Brattico E,Huotilainen M,Galunov V,Soloviev A,Sams M,Ilmoniemi RJ,Näätänen R

更新日期：2002-10-07 00:00:00

abstract：:24S-hydroxycholesterol, the primary oxidation product of cholesterol in the brain, plays a key role in cholesterol elimination and homeostasis. While the concentration of this neurotoxic oxysterol decreases with age, 24S-hydroxycholesterol is elevated in Alzheimer's disease. In this study, we examined the effects of 2...

journal_title：Neuroreport

authors： Alexandrov P,Cui JG,Zhao Y,Lukiw WJ

更新日期：2005-06-21 00:00:00

abstract：:A previous investigation has suggested that the hyperpolarization-activated cation current Ih does not contribute to the spontaneous firing of midbrain dopaminergic neurons. This conclusion was reached using Cs(-1). We have re-examined this question with extracellular recordings in slices using the more specific block...

journal_title：Neuroreport

authors： Seutin V,Massotte L,Renette MF,Dresse A

更新日期：2001-02-12 00:00:00

abstract：:It is a matter of dispute whether or not recurrent epileptic seizures cause neuronal damage in the human brain. We approached this question by measuring the volumes of the amygdala, hippocampus and parahippocampal gyrus with magnetic resonance imaging in 15 controls, 13 unmedicated patients with newly diagnosed epilep...

journal_title：Neuroreport

authors： Saukkonen A,Kälviäinen R,Partanen K,Vainio P,Riekkinen P,Pitkänen A

更新日期：1994-12-30 00:00:00

abstract：:Although functional asymmetries in the course of visual information processing have been known for a long time in humans as well as in non-human species, the structural basis of these asymmetries is largely unknown. We now report that due to an asymmetry of commissural projections in the pigeon the left nucleus rotund...

journal_title：Neuroreport

authors： Güntürkün O,Hellmann B,Melsbach G,Prior H

更新日期：1998-12-21 00:00:00

abstract：:It is well known that dendritic cells play a key role in producing antigen-specific responses. Inversely, tolerogenic dendritic cells (TolDCs), a specialized subset, induce immune tolerance and negatively regulate autoimmune responses. Statins, the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the m...

journal_title：Neuroreport

authors： Chen Z,Yang D,Peng X,Lin J,Su Z,Li J,Zhang X,Weng Y

更新日期：2018-03-07 00:00:00

abstract：:The distribution of c-fos proto-oncogene expression has been studied in the periaqueductal grey matter (PAG) of non-intentional-stimulated rats by immunohistochemistry. A mean number of 53 +/- 9 Fos-like immunoreactive cells per hemiPAG, distributed into three groups, dorsolateral, lateral and ventrolateral, was found...

journal_title：Neuroreport

authors： Valverde-Navarro AA,Olucha FE,García-Verdugo JM,Hernández-Gil T,Ruiz-Torner A,Martínez-Soriano F

更新日期：1996-11-04 00:00:00

abstract：:We investigated the effects of 2,2,2-trichloroethanol (TCE), the active metabolite of chloral hydrate, on large-conductance calcium-activated K+ channels (BKCa channels) of dorsal root ganglion (DRG) neurones. In outside-out patches, 2 and 5 mM TCE increased the open probability of BKCa channels to 1.7-fold and 2.8-fo...

journal_title：Neuroreport

authors： Gruss M,Hempelmann G,Scholz A

更新日期：2002-05-07 00:00:00

abstract：:The hypothesis that reactive free radical species (ROS) may contribute to the pathogenesis of Duchenne muscular dystrophy (DMD) has been suggested previously, but experimental data obtained in support of the above have to date proved inconclusive. The recent discovery that nitric oxide synthase (required for muscle re...

journal_title：Neuroreport

authors： Haycock JW,MacNeil S,Jones P,Harris JB,Mantle D

更新日期：1996-12-20 00:00:00

abstract：:We have evaluated the G1H line of transgenic mice overexpressing a familial ALS mutation of SOD1 (Gly-93-->Ala) in tasks assessing different aspects of motor function to determine how early these deficits could be detected and their order of appearance. The earliest deficits were observed in tests of muscle strength a...

journal_title：Neuroreport

authors： Barnéoud P,Lolivier J,Sanger DJ,Scatton B,Moser P

更新日期：1997-09-08 00:00:00

abstract：:S100B is a calcium-binding protein expressed and secreted by astrocytes, playing a neurotrophic role in neighboring cells. A protective role of the S100B against glutamate-induced excitotoxicity has recently been proposed. We investigated S100B secretion in rat hippocampal astrocytes exposed to high concentrations of ...

journal_title：Neuroreport

authors： Gonçalves D,Karl J,Leite M,Rotta L,Salbego C,Rocha E,Wofchuk S,Gonçalves CA

更新日期：2002-08-27 00:00:00

abstract：:Cisplatin is a widely used chemotherapeutic drug, but one of its side effects is ototoxicity. Epigenetic-related drugs, such as lysine-specific demethylase 1 (LSD1) inhibitors, have been reported to protect against cisplatin-induced hair cell loss by preventing demethylation of histone H3K4 (H3K4me2). However, the pro...

journal_title：Neuroreport

authors： Li A,He Y,Sun S,Cai C,Li H

更新日期：2015-06-17 00:00:00

abstract：:We used two developmental transcription factors, x-Eomes (T-box family) and x-Lhx5 (LIM-homeodomain family), to follow the origin and development of the olfactory bulbs in Xenopus. During embryonic and larval development, x-Eomes and x-Lhx5 were expressed in highly similar patterns, in the lateral and latero-ventral w...

journal_title：Neuroreport

authors： Moreno N,Bachy I,Rétaux S,González A

更新日期：2003-12-19 00:00:00

abstract：:After amputation of an arm the sensory map of the body changes radically, causing the sensory input from face to 'invade' the original hand area in the brain. As a result, touching the face of the amputee evokes tactile sensations on the phantom. These sensory referrals from the face to phantom hand occur in a stable,...

journal_title：Neuroreport

authors： Ramachandran VS,Brang D,McGeoch PD

更新日期：2010-07-14 00:00:00

abstract：:Serotonin (5-HT) is known to reduce apoptosis and in rodent models of brain ischemia. Modulation of programmed cell death during neural development was assessed in early postnatal brains of serotonin transporter (5-HTT) knockout mice, characterized by elevated extracellular 5-HT levels. The number of apoptotic cells v...

journal_title：Neuroreport

authors： Persico AM,Baldi A,Dell'Acqua ML,Moessner R,Murphy DL,Lesch KP,Keller F

更新日期：2003-03-03 00:00:00

abstract：:In acute experiments, the effects of i.p. 17beta-estradiol on the activity of arcuate neurons were studied in ovariectomized rats. 17Beta-estradiol (100 microg/100g, i.p.) increased the spontaneous activity of the observed arcuate neurons with a latency of 20-25 min. In some neurons spontaneous activity could be influ...

journal_title：Neuroreport

authors： Kis Z,Horváth S,Hoyk Z,Toldi J,Párducz A

更新日期：1999-11-26 00:00:00

abstract：:The current study aimed to investigate the altered cerebellar-cerebral functional connectivity (FC) induced by radiotherapy to nasopharyngeal carcinoma (NPC) patients. Twenty-four NPC patients without treatment, and 35 NPC patients receiving radiotherapy underwent functional MRI scanning. Montreal cognitive assessment...

journal_title：Neuroreport

authors： Ma Q,Zeng LL,Qin J,Luo Z,Su J,Wu D,Qiu S,Hu D

更新日期：2017-08-16 00:00:00

abstract：:Levels of mRNAs encoding for the two isoforms of glutamate decarboxylase, GAD67 and GAD65, were quantified in the rat striatum and cerebral cortex following single injections of the non-competitive NMDA receptor antagonist MK-801. Acute MK-801 induced a dose-dependent decrease in GAD65 mRNA levels in ventral sectors o...

journal_title：Neuroreport

authors： Laprade N,Soghomonian JJ

更新日期：1995-10-02 00:00:00

abstract：:Abnormal sleep architecture and white matter hyperintensities (WMHs) may be involved in cognitive impairment. There is little evidence on the connections between WMHs and chronic insomnia disorder (CID). Therefore, we evaluated the severity of WMHs and polysomnography parameters as well as cognitive tests to explore t...

journal_title：Neuroreport

authors： Lu S,Song L,Wang D,Zhang X,Lv X,Yin H,Gao Y,Liu X,Tang J

更新日期：2019-06-12 00:00:00

abstract：:One mechanism thought to mediate hand and upper limb control across motor cortices is called interhemispheric inhibition (IHI). Somatosensory cortices are important in the motor control of the hand, although the neural mechanisms by which somatic loci act are not fully understood. In the present study, we study the po...

journal_title：Neuroreport

authors： Zapallow CM,Jacobs MF,Lee KG,Asmussen MJ,Tsang P,Nelson AJ

更新日期：2013-05-08 00:00:00

abstract：:STC-1 cells have been established as an enteroendocrine cell line from the small intestine. By monitoring the level of intracellular Ca using a calcium-imaging technique, cellular responses of intestinal STC-1 cells to compounds of five basic tastants were investigated. Although this cell line was known to respond to ...

journal_title：Neuroreport

authors： Saitoh O,Hirano A,Nishimura Y

更新日期：2007-12-03 00:00:00

abstract：:The effects of histamine on N-methyl-d-aspartate (NMDA) receptor-mediated ion current in cultured rat cortical neurones have been investigated by superfusion of voltage-clamped (-80 mV) cells with 100 mM NMDA and with various concentrations of histamine. In a subpopulation of the neurones tested (30/53), histamine (10...

journal_title：Neuroreport

authors： Zwart R,Blank T,Spiess J

更新日期：1996-09-02 00:00:00

abstract：:Phosphorus magnetic resonance spectroscopy was used to determine effects of acute and chronic alcohol exposure on brain intracellular free magnesium concentration (Mgf) and bioenergetic state in rats. Acute alcohol (3 mg kg-1, i.p.) resulted in a transient ( < 2h) decline in brain Mgf and cytosolic phosphorylation rat...

journal_title：Neuroreport

authors： Mullins PG,Vink R

更新日期：1995-08-21 00:00:00

abstract：:As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TR beta (Thrb(tm1/tm1)) and is marked by early onset and persistence, thereby differing from mouse str...

journal_title：Neuroreport

authors： Ng L,Pedraza PE,Faris JS,Vennström B,Curran T,Morreale de Escobar G,Forrest D

更新日期：2001-08-08 00:00:00

abstract：:The neuropeptide nociceptin/orphanin FQ (N/OFQ) is implicated in many biological functions, including nociception, locomotor activity, stress and anxiety, drinking and food-intake. N/OFQ has also been reported to play a facilitatory role in acute kainate-induced seizures. The aim of the present study was to investigat...

journal_title：Neuroreport

authors： Binaschi A,Zucchini S,Bregola G,Rodi D,Mazzuferi M,Reinscheid RK,Simonato M

更新日期：2003-05-06 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) and its specific inhibitor, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), were analysed by enzyme-linked immunosorbent assay (ELISA) and by zymography in serum and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). In contrast to patients with ...

journal_title：Neuroreport

authors： Beuche W,Yushchenko M,Mäder M,Maliszewska M,Felgenhauer K,Weber F

更新日期：2000-11-09 00:00:00

abstract：:Chronic ethanol (EtOH) exposure can cause intracellular Ca overload by stimulating calcium channel receptors and trigger apoptosis of neurons. NCX3 may play a cytoprotective role in intracellular Ca excretion. In this study, the effect of EtOH on NCX3 was analyzed by observing NCX3 expression in the hippocampus of chr...

journal_title：Neuroreport

authors： Wang C,Wang X,Li Y,Xia Z,Liu Y,Yu H,Xu G,Wu X,Zhao R,Zhang G

更新日期：2019-04-10 00:00:00

abstract：:The efficacy and safety of thrombolysis with different dose regimens of recombinant tissue plasminogen activator (rt-PA) and its combination with aspirin was tested in an embolic stroke model. In rats the carotid territory was embolized with a single clot formed in a polyethylene tube and washed with saline. Fifteen m...

journal_title：Neuroreport

authors： Overgaard K,Sereghy T,Pedersen H,Boysen G

更新日期：1992-10-01 00:00:00