Kainic acid-induced seizures activate GSK-3β in the hippocampus of D2R-/- mice.

abstract：:Previous studies have established a role for N-methyl-D-aspartate receptor (NMDAR) containing the GluN2B subunit in efficient learning behavior on a variety of tasks. Recent findings have suggested that NMDAR on GABAergic interneurons may underlie the modulation of striatal function necessary to balance efficient acti...

journal_title：Neuroreport

authors： Brigman JL,Daut RA,Saksida L,Bussey TJ,Nakazawa K,Holmes A

更新日期：2015-06-17 00:00:00

abstract：:PEC-60, a 60-residue intestinal peptide structurally related to the pancreatic secretory type of trypsin inhibitor, has been isolated, characterized and molecularly cloned. It shows biological activity as a hormone in both the gastrointestinal tract and in the immune system. We now report immunohistochemical evidence ...

journal_title：Neuroreport

authors： Fuxe K,Tinner B,Metsis M,Staines W,Morassutti D,Agnati LF,Ostensson CG,Efendic S,Agerberth B,Goldstein M

更新日期：1994-09-08 00:00:00

abstract：:Perceptual regularities have been investigated intensely in music research but to a lesser extent in speech research possibly because of its irregular nature. People tend to rhythmize almost every given acoustic input though, even if one stimulus is physically identical to the next. Hence, perception of regularities s...

journal_title：Neuroreport

authors： Schmidt-Kassow M,Kotz SA

更新日期：2009-12-09 00:00:00

abstract：:Amyotrophic lateral sclerosis is an incurable disease in which cerebral and spinal motoneurons degenerate, causing paralysis and death within 2-5 years. One of the pathogenic factors of motoneuron death is a chronic excess of glutamate, which exceeds its removal by astrocytes, i.e. excitotoxicity. Extra glutamate upta...

journal_title：Neuroreport

authors： Wisman LA,van Muiswinkel FL,de Graan PN,Hol EM,Bär PR

更新日期：2003-10-27 00:00:00

abstract：:Counter-stimulation reduces pain perception; however, the role of attention during this process is rarely discussed despite attention itself being a well known modulator of pain perception. This study investigated the effect of attentional modulation on pain perception during counter-stimulation using fMRI. Subjects r...

journal_title：Neuroreport

authors： Longe SE,Wise R,Bantick S,Lloyd D,Johansen-Berg H,McGlone F,Tracey I

更新日期：2001-07-03 00:00:00

abstract：:Acid-sensing ion channels (ASICs) constitute a branch of the super-gene family of amiloride-sensitive sodium channels. So far five different ASICs have been cloned from mammalian tissues. They are activated by a drop of extracellular pH but differ with respect to effective agonist concentration, desensitization and mR...

journal_title：Neuroreport

authors： Gründer S,Geissler HS,Bässler EL,Ruppersberg JP

更新日期：2000-06-05 00:00:00

abstract：:The NMDA receptor is one of the ionotropic glutamate receptors essential for excitatory neurotransmission. The NMDAR1 subunit is inactivated by direct interaction with calmodulin. The protein levels of calmodulin, NMDAR1 and their complex were quantified in tissue resected from epileptogenic and non-epileptogenic cort...

journal_title：Neuroreport

authors： Mikuni N,Nishiyama K,Babb TL,Ying Z,Najm I,Okamoto T,Lüders HO,Wylie C

更新日期：1999-05-14 00:00:00

abstract：:DNA methylation is important for controlling gene expression and is catalyzed by DNA methyltransferase (Dnmt1) an enzyme abundant in brain. We recently demonstrated that mice expressing reduced levels of Dnmt1 are protected from cerebral ischemia. Here, we used the cre/loxP system to produce conditional mutants that l...

journal_title：Neuroreport

authors： Endres M,Fan G,Meisel A,Dirnagl U,Jaenisch R

更新日期：2001-12-04 00:00:00

abstract：:The efficacy and safety of thrombolysis with different dose regimens of recombinant tissue plasminogen activator (rt-PA) and its combination with aspirin was tested in an embolic stroke model. In rats the carotid territory was embolized with a single clot formed in a polyethylene tube and washed with saline. Fifteen m...

journal_title：Neuroreport

authors： Overgaard K,Sereghy T,Pedersen H,Boysen G

更新日期：1992-10-01 00:00:00

abstract：:Satiety signals from the gastrointestinal tract travel via vagal afferents to the nucleus of the solitary tract (NTS) in the brain stem, the first central relay in a neural network which controls food intake. The non-competitive NMDA antagonist MK-801 facilitates food intake in rats by acting on the NTS. Here we repor...

journal_title：Neuroreport

authors： Qian M,Zhu SW,Johnson AE,Södersten P

更新日期：2000-08-21 00:00:00

abstract：:The aim of this study is to investigate the neural mechanism of extending a brand in a specific product category to other product categories. Facing two sequential stimuli in pairs consisting of beverage brand names (stimulus 1) and product names (stimulus 2) in other categories, 16 participants were asked to indicate...

journal_title：Neuroreport

authors： Ma Q,Wang X,Dai S,Shu L

更新日期：2007-07-02 00:00:00

abstract：:Neonatal peripheral inflammation has been shown to alter the neural circuitry of the spinal cord in adult rats. However, the temporal and spatial changes in the distribution of primary afferent terminals immediately following a neonatal inflammatory stimulus remains unclear. In the present study we found that intrapla...

journal_title：Neuroreport

authors： Ling QD,Chien CC,Wen YR,Fu WM,Sun WZ

更新日期：2003-10-27 00:00:00

abstract：:Direct currents (DC) applied directly to central nervous system structures produce substantial and long-lasting effects in animal experiments. We tested the functional effects of very weak scalp DC (< 0.5 mA, 7 s) on the human motor cortex by assessing the changes in motor potentials evoked by transcranial magnetic br...

journal_title：Neuroreport

authors： Priori A,Berardelli A,Rona S,Accornero N,Manfredi M

更新日期：1998-07-13 00:00:00

abstract：:We investigated the reactive cytoskeletal changes following physical damage to axons in the rodent neocortex and compared these with the earliest neuronal alterations seen in Alzheimer's disease (AD). Insertion of a 25 gauge needle into the rodent somatosensory cortex resulted in ring- and club-like axonal changes cha...

journal_title：Neuroreport

authors： King CE,Jacobs I,Dickson TC,Vickers JC

更新日期：1997-05-06 00:00:00

abstract：:Adult male hamsters and rats were reared for 2 months in either an isolated condition (IC) or a social condition (SC). The lengths of synaptic active zones (SAZ) of synapses in the granule cell layer of the accessory olfactory bulb were measured as an indicator of synaptic size in perforated and non-perforated synapse...

journal_title：Neuroreport

authors： Matsuoka M,Mori Y,Ichikawa M

更新日期：1996-10-02 00:00:00

abstract：:The distribution of the enzyme NADPH diaphorase in the region of the periaqueductal gray (PAG) was studied in the rat, rabbit, cat, monkey and human. In each species, the enzyme labelled a small band of neurones located below the level of the aqueduct and directly above the supraoculomotor gray in the middle of the an...

journal_title：Neuroreport

authors： Carrive P,Paxinos G

更新日期：1994-11-21 00:00:00

abstract：:Hypoxic-ischemic brain damage (HIBD) occurs due to intrauterine hypoxia ischemia influencing the energy supply for fetal brain cells, which affects the metabolism of the brain to make the brain suffer a severe damage. Erythropoietin (EPO), which regulates hemacytopoiesis, is a kind of cytokine. EPO is sensitive to hyp...

journal_title：Neuroreport

authors： Huang R,Zhang J,Ren C,Zhang X,Gu L,Dong Y,Zhang J,Zhang J

更新日期：2019-03-06 00:00:00

abstract：:Microglial activation is a prominent feature of affected brain areas in multiple system atrophy. Microglia express proinflammatory peptides, which may be a result of activation of nuclear factor-KB. We investigated the nuclear presence of RelA, the 65 kDa subunit of the NF-KB/RelA family in striatum and brain stem of ...

journal_title：Neuroreport

authors： Schwarz SC,Seufferlein T,Liptay S,Schmid RM,Kasischke K,Foster OJ,Daniel S,Schwarz J

更新日期：1998-09-14 00:00:00

abstract：:5-HTt1A receptor agonists reduce the neuronal release of 5-hydroxytryptamine (5-HT) by activation of raphe 5-HT1A autoreceptors. Using in vivo microdialysis in unanesthetized rats, we show that the local application of the selective 5-HT1A receptor agonist 8-OH-DPAT decreased the 5-HT output to approximately 50% of co...

journal_title：Neuroreport

authors： Casanovas JM,Hervás I,Artigas F

更新日期：1999-05-14 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) channel has been found to be expressed in a variety of tissues over the last few years, including the central nervous system (CNS). However, the distribution of TRPV1 in the CNS remains a controversial question. Here, we reveal that the expression of TRPV1 can be detect...

journal_title：Neuroreport

authors： Huang WX,Min JW,Liu YQ,He XH,Peng BW

更新日期：2014-04-16 00:00:00

abstract：:We investigated the effect of an NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA), on the levels of endogenous GABA in the rat striatum using in vivo microdialysis. Rats were perfused with the artificial CSF containing L-NMMA (0.1, 0.3 and 1.0 mM) or its inactive isomer D-NMMA (1.0 mM) for 1 h. Infusion of L-N...

journal_title：Neuroreport

authors： Semba J,Sakai M,Miyoshi R,Kito S

更新日期：1995-07-10 00:00:00

abstract：:The aim was to study whether there is indication of a dissociation in processing of visuospatial and colour information in working memory in humans. Experimental subjects performed visuospatial and colour n-back tasks with and without visuospatial and colour distractive stimuli presented in the middle of the delay per...

journal_title：Neuroreport

authors： Vuontela V,Rämä P,Raninen A,Aronen HJ,Carlson S

更新日期：1999-08-02 00:00:00

abstract：:Neurite outgrowth involves various molecular mechanisms generating complex brain connections. These mechanisms have been linked to plasticity and learning and are thought to be deregulated in neuropsychiatric diseases. The transcription factor REST/NRSF regulates a subset of genes encoding neurite outgrowth molecules....

journal_title：Neuroreport

authors： Lepagnol-Bestel AM,Maussion G,Ramoz N,Moalic JM,Gorwood P,Simonneau M

更新日期：2007-03-26 00:00:00

abstract：:Reward-processing neurocircuitry has been delineated using verbal or visual processing and/or decision-making tasks. We examined more basic processes of listening to enjoyable music in healthy and depressed patients. The paradigm was passive, individualized, and brief. Sixteen depressed and 15 control individuals prov...

journal_title：Neuroreport

authors： Osuch EA,Bluhm RL,Williamson PC,Théberge J,Densmore M,Neufeld RW

更新日期：2009-08-26 00:00:00

abstract：:Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD pa...

journal_title：Neuroreport

authors： Rauchs G,Schabus M,Parapatics S,Bertran F,Clochon P,Hot P,Denise P,Desgranges B,Eustache F,Gruber G,Anderer P

更新日期：2008-07-16 00:00:00

abstract：:Selective degeneration of hypothalamic orexin neurons, a hallmark of pathology in narcolepsy patients, is in part reproduced in hypothalamic slice cultures by application of an endogenous excitotoxin quinolinic acid. Depolarized membrane potential may be responsible for the vulnerability of orexin neurons to excitotox...

journal_title：Neuroreport

authors： Katsuki H,Akaike A

更新日期：2005-08-01 00:00:00

abstract：:We used whole-cell recording to identify, for the first time, GABAergic tonic current in subpopulations of substantia gelatinosa neurons in mouse spinal cord slices. Application of the gamma-aminobutyric acid type A receptor antagonist bicuculline revealed tonic currents in 49 of 73 substantia gelatinosa neurons. Thes...

journal_title：Neuroreport

authors： Takahashi A,Mashimo T,Uchida I

更新日期：2006-08-21 00:00:00

abstract：:We examined the role of main and external cuneate nuclei neurons in processing sensory information during forelimb passive movement. We recorded activity of neurons using circular and figure-eight trajectories, at different speeds, in anaesthetized rats. A multivariate regression analysis was performed to correlate ne...

journal_title：Neuroreport

authors： Garifoli A,Caserta C,Bosco G,Lombardo SA,Casabona A,Perciavalle V

更新日期：2002-03-04 00:00:00

abstract：:Motor fluctuations that ultimately complicate the response of most parkinsonian patients to levodopa therapy might represent a form of behavioral or neuronal plasticity. Since various forms of neuronal plasticity appear to be mediated by glutamate transmission through the N-methyl-D-aspartate (NMDA) receptor, the effe...

journal_title：Neuroreport

authors： Engber TM,Papa SM,Boldry RC,Chase TN

更新日期：1994-12-20 00:00:00

abstract：:It has been hypothesized that the vomeronasal system (VNS), a complex neural network implicated in the control of reproductive behaviors, is sexually dimorphic. The posteromedial cortical amygdaloid nucleus (PMCo) belongs to the group of amygdaloid structures that receive direct olfactory input from the accessory olfa...

journal_title：Neuroreport

authors： Vinader-Caerols C,Collado P,Segovia S,Guillamón A

更新日期：1998-08-03 00:00:00