Abstract:
:Amyotrophic lateral sclerosis is an incurable disease in which cerebral and spinal motoneurons degenerate, causing paralysis and death within 2-5 years. One of the pathogenic factors of motoneuron death is a chronic excess of glutamate, which exceeds its removal by astrocytes, i.e. excitotoxicity. Extra glutamate uptake in the spinal cord may slow down or prevent motoneuron death. We have engineered cells over-expressing the main glutamate transporter and tested their potential to rescue motoneurons exposed to high levels of glutamate in vitro. The engineered cells protected motoneurons in a motoneuron-astrocyte co-culture at glutamate concentrations when astrocytes were no longer capable of removing glutamate. This suggests that engineered cells, introduced into the spinal column, can help remove glutamate, thereby preventing motoneuron death.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Wisman LA,van Muiswinkel FL,de Graan PN,Hol EM,Bär PRdoi
10.1097/00001756-200310270-00017subject
Has Abstractpub_date
2003-10-27 00:00:00pages
1967-70issue
15eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
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