Abstract:
:Ts65DN mice were developed as a model of Down syndrome (DS); they are trisomic for the distal segment of chromosome 16 (MMU16), which contains genes syntenic with some of the genes located on the critical region of human chromosome 21 (HSA21). Since behavioral and neurochemical disturbances have been observed in this animal model, it seemed interesting to perform an immunohistochemical characterization of the main cholinergic, catecholaminergic and serotonergic nuclei. However, when the brains of Ts65Dn mice were compared with those of control littermates, no differences were found either in the morphology of the neurons of the three systems or in the number of immunoreactive cells. The results indicate that these systems are not affected by the triplication of some of the genes present on chromosome 16.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Megías M,Verduga R,Dierssen M,Flórez J,Insausti R,Crespo Ddoi
10.1097/00001756-199711100-00012subject
Has Abstractpub_date
1997-11-10 00:00:00pages
3475-8issue
16eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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