Schwann cells in rat vascular autonomic nerves activated via purinergic receptors.

Abstract:

:Schwann cells at the somatic neuromuscular junction possess adenosine receptors that when activated by the release of endogenous transmitter modulate quantal transmitter release. Recently, purinergic receptors have been shown to exist on Schwann cells of axon varicosities in visceral smooth muscle where they are activated by endogenous transmitters to give a calcium transient, although adenosine receptors were not identified. In the present work, we show that Schwann cells associated with axon varicosities of vascular smooth muscle, namely that of mesenteric blood vessels, possess both adenosine and purinergic receptors that when activated give rise to calcium transients in these cells. Then qualitative differences exist in the extent of adenosine and purine receptors that give rise to calcium transients in Schwann cells located in these different muscles.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Lin YQ,Bennett MR

doi

10.1097/01.wnr.0000209001.09987.77

subject

Has Abstract

pub_date

2006-04-03 00:00:00

pages

531-5

issue

5

eissn

0959-4965

issn

1473-558X

pii

00001756-200604030-00015

journal_volume

17

pub_type

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