Histamine slows the onset of desensitization of rat cortical NMDA receptors.

Abstract:

:The effects of histamine on N-methyl-d-aspartate (NMDA) receptor-mediated ion current in cultured rat cortical neurones have been investigated by superfusion of voltage-clamped (-80 mV) cells with 100 mM NMDA and with various concentrations of histamine. In a subpopulation of the neurones tested (30/53), histamine (10-100 mM) enhanced the peak amplitude, and slowed down the onset of desensitization of the NMDA-induced ion currents, both in a concentration-dependent manner. No effects of histamine on the kinetics of recovery from desensitization were detected. In other neurones (21/53), histamine had no effect on the NMDA-induced currents and in two of the neurones tested histamine potentiated NMDA-induced currents without a detectable effect on desensitization kinetics. The results indicate that in a subpopulation of rat cortical neurones histamine potentiates NMDA-induced ion currents by slowing the kinetics of onset of desensitization.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Zwart R,Blank T,Spiess J

doi

10.1097/00001756-199609020-00030

subject

Has Abstract

pub_date

1996-09-02 00:00:00

pages

2206-10

issue

13

eissn

0959-4965

issn

1473-558X

journal_volume

7

pub_type

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