Abstract:
:Infection with human immunodeficiency virus (HIV)-1 can lead to neurological complications that range from mild cognitive and motor impairment to HIV-associated dementia (HAD). The mechanism of brain injury and dementia remains poorly understood. Interestingly, post mortem brain specimen from HAD patients and transgenic mice expressing the viral envelope protein gp120 present with similar neuropathological signs. The cytokine erythropoietin (EPO) is clinically used to treat anemia but has also been found to prevent neuronal death due to inflammation or excitotoxicity. Here we show that EPO protects cerebrocortical neurons against apoptosis induced by HIV-1/gp120.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Digicaylioglu M,Kaul M,Fletcher L,Dowen R,Lipton SAdoi
10.1097/00001756-200404090-00004subject
Has Abstractpub_date
2004-04-09 00:00:00pages
761-3issue
5eissn
0959-4965issn
1473-558Xpii
00001756-200404090-00004journal_volume
15pub_type
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