Erythropoietin protects cerebrocortical neurons from HIV-1/gp120-induced damage.

Abstract:

:Infection with human immunodeficiency virus (HIV)-1 can lead to neurological complications that range from mild cognitive and motor impairment to HIV-associated dementia (HAD). The mechanism of brain injury and dementia remains poorly understood. Interestingly, post mortem brain specimen from HAD patients and transgenic mice expressing the viral envelope protein gp120 present with similar neuropathological signs. The cytokine erythropoietin (EPO) is clinically used to treat anemia but has also been found to prevent neuronal death due to inflammation or excitotoxicity. Here we show that EPO protects cerebrocortical neurons against apoptosis induced by HIV-1/gp120.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Digicaylioglu M,Kaul M,Fletcher L,Dowen R,Lipton SA

doi

10.1097/00001756-200404090-00004

subject

Has Abstract

pub_date

2004-04-09 00:00:00

pages

761-3

issue

5

eissn

0959-4965

issn

1473-558X

pii

00001756-200404090-00004

journal_volume

15

pub_type

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