Abstract:
:Matrix metalloproteinase-9 (MMP-9) and its specific inhibitor, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), were analysed by enzyme-linked immunosorbent assay (ELISA) and by zymography in serum and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). In contrast to patients with inflammatory diseases, MMP-9 levels were not elevated in CSF of ALS patients. In serum, however, compared to healthy donors, MMP-9 was significantly (p = 0.0003) increased up to levels as high as those of viral meningoencephalitis (VM) or bacterial meningitis (BM) patients. MMP-9 levels remained elevated during long-term observation of ALS patients. In the absence of an inflammatory response, the results indicate that the increase of MMP-9 in serum of ALS patients might be caused by upregulation of MMP-9 in denervated muscles or in degenerating peripheral nerves following motor neurone loss.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Beuche W,Yushchenko M,Mäder M,Maliszewska M,Felgenhauer K,Weber Fdoi
10.1097/00001756-200011090-00003subject
Has Abstractpub_date
2000-11-09 00:00:00pages
3419-22issue
16eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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