Effects of body weight-supported treadmill training at different speeds on the motor function and depressive behaviors after spinal cord injury in rats.

abstract：:beta-N-methylamino-L-alanine (L-BMAA) is an excitotoxin whose neurodegenerative effects are associated with its agonist properties at the N-methyl-D-aspartate (NMDA) receptor. We measured the effects of L-BMAA on inositol phosphate (InsP) formation in primary cultured striatal neurons. This culture is almost devoid of...

journal_title：Neuroreport

authors： Manzoni OJ,Prezeau L,Bockaert J

更新日期：1991-10-01 00:00:00

abstract：:Altered glutamate signaling is associated with Parkinson's disease. To study the involvement of the cystine/glutamate antiporter in the pathogenesis of Parkinson's disease, we developed new polyclonal antibodies recognizing xCT, the specific subunit of this antiporter. The striatal xCT protein expression level was inv...

journal_title：Neuroreport

authors： Massie A,Schallier A,Mertens B,Vermoesen K,Bannai S,Sato H,Smolders I,Michotte Y

更新日期：2008-10-29 00:00:00

abstract：:The effects of histamine on N-methyl-d-aspartate (NMDA) receptor-mediated ion current in cultured rat cortical neurones have been investigated by superfusion of voltage-clamped (-80 mV) cells with 100 mM NMDA and with various concentrations of histamine. In a subpopulation of the neurones tested (30/53), histamine (10...

journal_title：Neuroreport

authors： Zwart R,Blank T,Spiess J

更新日期：1996-09-02 00:00:00

abstract：:The event-related potential technique was used to investigate the time course and scalp-potential topography for the numerical distance effect in a number-matching task. Twenty undergraduates judged whether a number matched or did not match another number presented 1.5 s earlier. Compared with number pairs with a 'sma...

journal_title：Neuroreport

authors： Zhou X,Chen C,Dong Q,Zhang H,Chen C,Qiao S,Zhao H,Jiang T,Guo Y

更新日期：2006-07-17 00:00:00

abstract：:One mechanism thought to mediate hand and upper limb control across motor cortices is called interhemispheric inhibition (IHI). Somatosensory cortices are important in the motor control of the hand, although the neural mechanisms by which somatic loci act are not fully understood. In the present study, we study the po...

journal_title：Neuroreport

authors： Zapallow CM,Jacobs MF,Lee KG,Asmussen MJ,Tsang P,Nelson AJ

更新日期：2013-05-08 00:00:00

abstract：:Two monkeys were trained to perform wrist movements to align a pointer with visual targets. In the spatially 'compatible' condition, monkeys had to point at the target position (left/right), whereas in the 'incompatible' condition, they had to point at the position opposite to the target. A large proportion of neurone...

journal_title：Neuroreport

authors： Riehle A,Kornblum S,Requin J

更新日期：1994-12-20 00:00:00

abstract：:The aim of this study was to determine the changes of the nociceptive thresholds in response to an acute mechanical stimulus (paw pressure) in magnesium (Mg)-deficient rats, and the involvement of the NMDA receptor in these changes. Changes in vocalization thresholds was determined after 7 days of feeding with a Mg-de...

journal_title：Neuroreport

authors： Dubray C,Alloui A,Bardin L,Rock E,Mazur A,Rayssiguier Y,Eschalier A,Lavarenne J

更新日期：1997-04-14 00:00:00

abstract：:In order to ascertain whether disturbances of neurogenesis occur in chronic neurodegenerative disorders, we assessed hippocampal cell proliferation in the R6/1 transgenic mouse model of Huntington's disease (HD). Using BrdU labelling for dividing cells at two different time points (5 and 20 weeks) in transgenic and wi...

journal_title：Neuroreport

authors： Lazic SE,Grote H,Armstrong RJ,Blakemore C,Hannan AJ,van Dellen A,Barker RA

更新日期：2004-04-09 00:00:00

abstract：:Bone marrow stromal cells are multipotent stem cells that have the potential to differentiate into bone, cartilage, fat and muscle. Recently, bone marrow stromal cells have been shown to have the capacity to differentiate into neurons under specific experimental conditions, using chemical factors. We now describe how ...

journal_title：Neuroreport

authors： Zurita M,Vaquero J,Oya S,Miguel M

更新日期：2005-04-04 00:00:00

abstract：:Previously we found that musicians have significantly larger anterior corpus callosum (CC). In the current study, we intended to replicate and extend our previous results using a new and larger sample of gender-matched subjects (56 right-handed professional musicians and 56 age- and handedness-matched controls). We fo...

journal_title：Neuroreport

authors： Lee DJ,Chen Y,Schlaug G

更新日期：2003-02-10 00:00:00

abstract：:Neuronal activity may lead to long lasting changes in cell phenotype through induction of genes such as c-fos which encode transcriptional regulatory factors. Odor-activated olfactory bulb cells exhibit increases in c-fos mRNA expression. The present study examined whether odor stimulation of awake rats also leads to ...

journal_title：Neuroreport

authors： Guthrie KM,Gall CM

更新日期：1995-11-13 00:00:00

abstract：:Diffusion tensor imaging (DTI) can non-invasively examine the molecular diffusion of water in vivo and directly reflects the anatomical integrity of neural fibers in white matter. Fractional anisotropy (FA) can be calculated from DTI data, and utilized to evaluate white matter integrity. DTI was performed on 30 patien...

journal_title：Neuroreport

authors： Sun Z,Wang F,Cui L,Breeze J,Du X,Wang X,Cong Z,Zhang H,Li B,Hong N,Zhang D

更新日期：2003-10-06 00:00:00

abstract：:Neuroimaging techniques, such as fMRI, PET and near-infrared spectroscopy, monitor task-related neuronal activations in the brain indirectly through the associated neurovascular/metabolic responses. To assess the primary neuronal activations directly, magnetoencephalography was combined here with a mechanical modulati...

journal_title：Neuroreport

authors： Mackert BM,Wübbeler G,Leistner S,Trahms L,Curio G

更新日期：2001-06-13 00:00:00

abstract：:Poly(ADP-ribose) polymerase-1 consumes NAD to catalyze poly(ADP-ribosyl)ation of target proteins, which modulates various biological functions. However, excessive poly(ADP-ribose) polymerase-1 activation mediates oxidative cell death. Our recent studies have indicated that NAD can enter into astrocytes to prevent poly...

journal_title：Neuroreport

authors： Zhu K,Swanson RA,Ying W

更新日期：2005-08-01 00:00:00

abstract：:The pathogenesis of cerebral ischemia/reperfusion (I/R) involves cytokine/chemokine production, inflammatory cell influx, astrogliosis, cytoskeletal protein degradation and breakdown of the blood-brain barrier. (-)-Naloxone is able to reduce infarct volume and has been used as a therapeutic agent for cerebral I/R inju...

journal_title：Neuroreport

authors： Chen CJ,Liao SL,Chen WY,Hong JS,Kuo JS

更新日期：2001-05-08 00:00:00

abstract：:Modulation of the soleus H-reflex following galvanic vestibular stimulation (GVS) has been used to evaluate vestibulospinal tract function. It is not known whether this modulation is because of vestibular stimulation and/or cutaneous stimulation, and the suitable stimulating intensity of GVS for the modulation is not ...

journal_title：Neuroreport

authors： Okada Y,Shiozaki T,Nakamura J,Azumi Y,Inazato M,Ono M,Kondo H,Sugitani M,Matsugi A

更新日期：2018-09-05 00:00:00

abstract：:Plasminogen activator inhibitor-1 is a serpin that regulates the activities of plasminogen activators. However, its physiological roles in the CNS are incompletely understood. We have found that plasminogen activator inhibitor-1 has a novel biological function in the CNS: the contribution to survival of neurites on ne...

journal_title：Neuroreport

authors： Soeda S,Imatoh T,Ochiai T,Koyanagi S,Shimeno H

更新日期：2004-04-09 00:00:00

abstract：:All-night recordings of respiration, ballistocardiogram, and body movements were obtained using the static charge-sensitive bed (SCSB) and automatically analysed data were compared with sleep stages. The mean sum of eight SCSB variability parameters was lowest in slow wave sleep (SWS), higher during stage 2 (S2), and ...

journal_title：Neuroreport

authors： Kaartinen J,Erkinjutti M,Rauhala E

更新日期：1996-04-10 00:00:00

abstract：:Humans afflicted with mood disorders respond differently to antidepressant drug therapy. Different responses to psychoactive drugs are also observed in rats, and specific strains exhibit substantial differences in gene expression following synaptic activity. We examined the effects of fluoxetine on the induction of Fo...

journal_title：Neuroreport

authors： Horowitz JM,Hallas BH,Torres G

更新日期：2002-12-20 00:00:00

abstract：:An anti-leptin polyclonal antiserum was used to detect leptin-immunoreactivity (-ir) in the central nervous system in rats. Leptin-ir was found in perikaryon and processes of neurons in the hypothalamus, including the paraventricular nucleus, and in several regions in the brainstem, including the nucleus of the solita...

journal_title：Neuroreport

authors： Li HY,Wang LL,Yeh RS

更新日期：1999-02-05 00:00:00

abstract：:Propofol is widely used for induction and maintenance of anaesthesia, which causes a rapid loss of consciousness. So far the mechanisms underlying the effect of propofol are still largely unknown. Here, we found that microinjection of propofol in the lateral hypothalamus caused a significant decrease in wakefulness an...

journal_title：Neuroreport

authors： Shi Y,Xiao D,Dai L,Si Y,Fang Q,Wei X

更新日期：2019-10-09 00:00:00

abstract：:Previous studies have suggested that the dorsomedial prefrontal cortex (dmPFC) plays a central role in processing first impressions; however, little is known about how dmPFC processes different valences of first impressions. Moreover, it is still unclear as to whether the dmPFC shows lateralization or only induces dif...

journal_title：Neuroreport

authors： Yu CL,Wang MY,Hu JF

更新日期：2016-05-25 00:00:00

abstract：:Neuropathological and neuroimaging studies indicate a decrease in Purkinje cell (PC) density in the cerebellum of autistic patients and rodent models of autism. Autism is far more prevalent in males than females, and sex-specific properties of PCs have been reported recently. We investigated the differential sensitivi...

journal_title：Neuroreport

authors： Roux S,Bailly Y,Bossu JL

更新日期：2019-01-16 00:00:00

abstract：:Epidemiological data show correlations between hypercholesterolemia and Alzheimer's disease (AD). We test the hypothesis that hypercholesterolemia modulates Abeta deposition in mice overexpressing the human APP695 Swedish mutation (K670N and M671L) (TgAPPsw). Feeding mice a high fat/high cholesterol (HFHC) diet for 7-...

journal_title：Neuroreport

authors： Shie FS,Jin LW,Cook DG,Leverenz JB,LeBoeuf RC

更新日期：2002-03-25 00:00:00

abstract：:Formalin fixation reduces beta-amyloid precursor protein (beta APP) immunoreactivity which restricts its study in archival tissue. Formic acid pretreatment has previously been used in an attempt to overcome this problem, but makes the sections very friable. In the present study, a microwave antigen retrieval method ha...

journal_title：Neuroreport

authors： Sherriff FE,Bridges LR,Jackson P

更新日期：1994-05-09 00:00:00

abstract：:Ischemic stroke is the most frequent cause of long-term morbidity and mortality in the elderly worldwide. Mild hypothermia (32-35°C) has been found to have a neuroprotective effect against ischemic stroke. However, the protective mechanisms remain unclear. In the present study, we explore the neuroprotective effect of...

journal_title：Neuroreport

authors： Gao Z,Zhang Z,Bian Q,Li Y,Ma D,Liu Z,Zhang S

更新日期：2021-01-18 00:00:00

abstract：:I have investigated the role of Ca2+ on M-current (IK(M)) inhibition by the muscarinic agonist oxo-M using the perforated patch voltage clamp technique. Oxo-M inhibited IK(M) in cultured SCG cells with an IC50 of 1.2 microM in 2 mM [Ca2+]o, and 13.1 microM in nominally Ca(2+)-free external solution. BAPTA-AM, ryanodin...

journal_title：Neuroreport

authors： Lamas JA

更新日期：1999-08-02 00:00:00

abstract：:Deficits in processing of auditory stimuli are known to play an important role in the aetiology of dyslexia. To specify the auditory deficit in children at risk for dyslexia, 19 children with a phonological deficit and 15 controls were tested using the mismatch negativity event-related potential, which reflects preatt...

journal_title：Neuroreport

authors： Bitz U,Gust K,Spitzer M,Kiefer M

更新日期：2007-06-11 00:00:00

abstract：:Bilateral voluntary contractions involve functional changes in both primary motor cortices. However how the unilateral voluntary contraction of hand muscles influences the contralateral corticomuscular synchronous oscillations mechanisms remains unclear. In the bimanual tasks, nine healthy subjects were instructed to ...

journal_title：Neuroreport

authors： Li S,Fan M,Yu H,Gao L

更新日期：2020-03-04 00:00:00

abstract：:A double-stranded DNA end-binding factor with high levels of expression in brain and testis of adult mice was identified as the Ku protein, earlier described as an autoantigen in connective tissue diseases and found to be essential for recombination of the immunoglobulin genes and DNA repair. High Ku levels were found...

journal_title：Neuroreport

authors： Bakalkin G,Yakovleva T,Hurd YL,Nussenzweig A,Li GC,Terenius L

更新日期：1998-06-22 00:00:00