Microwave antigen retrieval of beta-amyloid precursor protein immunoreactivity.

Abstract:

:Formalin fixation reduces beta-amyloid precursor protein (beta APP) immunoreactivity which restricts its study in archival tissue. Formic acid pretreatment has previously been used in an attempt to overcome this problem, but makes the sections very friable. In the present study, a microwave antigen retrieval method has been compared with formic acid pretreatment for retrieving beta APP immunoreactivity in formalin-fixed, paraffin-embedded human brain tissue. Microwave treatment resulted in superior retrieval of beta APP antigenicity in dystrophic neurites in Alzheimer's disease and in injured axons after head injury, using antibodies to three different epitopes. Unlike formic acid, microwave treatment causes minimal adverse effects on the strength and slide adhesion of the sections.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Sherriff FE,Bridges LR,Jackson P

doi

10.1097/00001756-199405000-00016

subject

Has Abstract

pub_date

1994-05-09 00:00:00

pages

1085-8

issue

9

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

杂志文章
  • Error-related negativities elicited by monetary loss and cues that predict loss.

    abstract::Event-related potential studies have reported error-related negativity following both error commission and feedback indicating errors or monetary loss. The present study examined whether error-related negativities could be elicited by a predictive cue presented prior to both the decision and subsequent feedback in a g...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f0d50b

    authors: Dunning JP,Hajcak G

    更新日期:2007-11-19 00:00:00

  • Physiology of morphologically identified cells of the bullfrog fungiform papilla.

    abstract::Voltage-gated ionic current and the response to quinine were studied on the four types of morphologically identified taste cells of the bullfrog fungiform papilla by whole-cell patch clamp recording with a Lucifer yellow-filled pipette. Dye-coupled type Ia cells (mucous cells) did not show voltage-activated currents. ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200109170-00040

    authors: Takeuchi H,Tsunenari T,Kurahashi T,Kaneko A

    更新日期:2001-09-17 00:00:00

  • R-citalopram prevents the neuronal adaptive changes induced by escitalopram.

    abstract::This study examined the long-term effects of the antidepressant escitalopram on rat serotonin (5-HT) neuronal activity and hippocampal neuroplasticity. In the dorsal raphe nucleus, a 2-week treatment with escitalopram (10 mg/kg/day, subcutaneous) did not modify the firing activity of 5-HT neurons, whereas a cotreatmen...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f04047

    authors: Mnie-Filali O,Faure C,Mansari ME,Lambás-Señas L,Bérod A,Zimmer L,Sánchez C,Haddjeri N

    更新日期:2007-10-08 00:00:00

  • In vivo studies with [125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand.

    abstract::5-[125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine ([125I]5-I-A-85380) was evaluated in the mouse as a potential in vivo imaging ligand for central nicotinic acetylcholine receptors (nAChRs). After i.v. administration of [125I]5-I-A-85380, peak brain levels of radioactivity were measured within 1 h and declined slowly ov...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199807130-00030

    authors: Vaupel DB,Mukhin AG,Kimes AS,Horti AG,Koren AO,London ED

    更新日期:1998-07-13 00:00:00

  • Heparin facilitates glial cell line-derived neurotrophic factor signal transduction.

    abstract::Glial cell-line neurotrophic factor (GDNF), a neurotrophic factor with heparin binding affinity, promotes the survival and differentiation of a variety of neuronal cells including dopaminergic neuron. The effect of heparin on GDNF signaling was investigated based on the expression of the tyrosine hydroxyrase (TH) gene...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200210280-00016

    authors: Tanaka M,Xiao H,Kiuchi K

    更新日期:2002-10-28 00:00:00

  • Correlations, feature-binding and population coding in primary visual cortex.

    abstract::To test the hypothesis that correlated neuronal activity serves as the neuronal code for visual feature binding, we applied information theory techniques to multiunit activity recorded from pairs of V1 recording sites in anaesthetised cats while presenting either single or separate bar stimuli. We quantified the roles...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000073681.00308.9c

    authors: Golledge HD,Panzeri S,Zheng F,Pola G,Scannell JW,Giannikopoulos DV,Mason RJ,Tovée MJ,Young MP

    更新日期:2003-05-23 00:00:00

  • Long-term depression but not potentiation is induced in Ca(2+)-chelated visual cortex neurons.

    abstract::An entry of Ca2+ into postsynaptic sites may play a role in the induction of long-term potentiation (LTP) of synaptic transmission in the visual cortex. To test this hypothesis, a Ca(2+)-chelator was injected into layer II/III neurons of sliced visual cortex obtained from young rats, and excitatory postsynaptic potent...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199009000-00018

    authors: Kimura F,Tsumoto T,Nishigori A,Yoshimura Y

    更新日期:1990-09-01 00:00:00

  • Neuroanatomic correlates of autism and stereotypy in children with Down syndrome.

    abstract::We conducted semiautomated, atlas-based analyses of regional brain volume changes on MRIs of children and adolescents with Down syndrome (DS) (N=15), DS with comorbid autism spectrum disorder (ASD) (N=15), and age-matched or sex-matched typically developing controls (N=22). Selective volumetric changes were correlated...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282faa8d8

    authors: Carter JC,Capone GT,Kaufmann WE

    更新日期:2008-04-16 00:00:00

  • To bet or not to bet? The coding of bets modulates brain potentials in outcome evaluations.

    abstract::Decisions made on the basis of risk often require rapid evaluation of feedback before follow-up actions and feedback-related negativity in brain potential is sensitive to the poor outcome. The current study investigated the effects of feedback from one's own decision (Experiment 1) and feedback from observing others' ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000452

    authors: Liu Y,Dou K,Wang Y,Li J

    更新日期:2015-11-11 00:00:00

  • MK-801, an NMDA receptor antagonist, in the rostroventromedial medulla attenuates development of neuropathic symptoms in the rat.

    abstract::Segmental ligation of spinal nerves in the rat induces a long-lasting hyperalgesia and allodynia that mimicks neuropathic conditions in humans. In the present study we attempted to determine whether supraspinal NMDA receptors contribute to the induction of the long-lasting hypersensitivity to noxious and innocuous mec...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199909290-00011

    authors: Wei H,Pertovaara A

    更新日期:1999-09-29 00:00:00

  • Human short latency cortical responses to somatosensory stimulation. A high resolution EEG study.

    abstract::Human short-latency cortical responses to median nerve stimulation were investigated with a new high resolution electroencephalography technology that markedly enhanced spatial details of somatosensory-evoked potentials (SEPs). Maximum amplitude potentials were estimated over contralateral and/or frontal-mesial scalp ...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199710200-00011

    authors: Urbano A,Babiloni F,Babiloni C,Ambrosini A,Onorati P,Rossini PM

    更新日期:1997-10-20 00:00:00

  • Comparison of visual--vestibular interaction in insulin-dependent and non-insulin-dependent diabetes mellitus.

    abstract::We compared various measures of visual-vestibular interaction in subjects with insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM), as well as non-diabetic controls. Subjects with IDDM exhibited significantly greater postural sway than controls on those conditions in the Clini...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200002280-00012

    authors: Darlington CL,Erasmus J,Nicholson M,King J,Smith PF

    更新日期:2000-02-28 00:00:00

  • Mutational characterization of ATP7B gene in 103 Wilson's disease patients from Southern China: identification of three novel mutations.

    abstract::Wilson's disease (WD) is an autosomal recessive inheritance disorder of copper metabolism due to mutations in the ATP7B gene. The distribution of ATP7B gene mutations is diverse in different population. This study aimed to examine the genotypes of the ATP7B mutant alleles in WD patients from Southern China. Genomic DN...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000216

    authors: Wei Z,Huang Y,Liu A,Diao S,Yu Q,Peng Z,Hong M

    更新日期:2014-10-01 00:00:00

  • Amino alcohol modulation of hippocampal acetylcholine release.

    abstract::The synthesis and release of 3H-acetylcholine was measured in hippocampal slices of adult rat brain following acute in vitro exposure to ethanolamine. Evoked release of 3H-acetylcholine was elevated by 60-70% but 3H-acetylcholine synthesis was unaffected. Other amino alcohols were also found to significantly increase ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199205000-00012

    authors: Bostwick JR,Abbe R,Sun J,Appel SH

    更新日期:1992-05-01 00:00:00

  • Pathway-specific expression of PKC and PKA in sympathetic neurons.

    abstract::We used multiple-labelling immunofluorescence, intracellular dye injection, electrophysiological recording and confocal microscopy to examine the expression of immunoreactivity to protein kinase C (PKC) and protein kinase A (PKA) in sympathetic ganglia of guinea-pigs. PKCalpha and PKCgamma were widespread in vasoconst...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199904060-00015

    authors: Gibbins IL,Matthew SE,Jobling P

    更新日期:1999-04-06 00:00:00

  • Absence of M100 source asymmetry in autism associated with language functioning.

    abstract::Various clinical populations display atypical volume asymmetry of language structures and also the auditory M100 source. Although such atypical volume asymmetries have also been observed in autism, M100 source asymmetries have not yet been investigated. We examined M100 asymmetry in autism and its relationship with la...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32832e0ca7

    authors: Schmidt GL,Rey MM,Oram Cardy JE,Roberts TP

    更新日期:2009-07-15 00:00:00

  • Nuclear triiodothyronine receptor expression is regulated by axon-Schwann cell contact.

    abstract::Thyroid hormones, which play an important role in the development and regeneration of the nervous system, require the presence of specific nuclear T3 receptors (NT3R). In this study we provide evidence that NT3R expression by Schwann cells was up-regulated in response to a loss of axonal contact in vitro and in vivo. ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199311180-00010

    authors: Walter IB

    更新日期:1993-11-18 00:00:00

  • Ca2+-dependent kinetics of hair cell Ca2+ currents resolved with the use of cesium BAPTA.

    abstract::Hair cells in the frog semicircular canal, studied by the whole-cell patch-clamp technique, display three distinct Ca2+ currents: two non-inactivating components (L type and R type, the latter termed R2 in the following) and a second R type current (termed R1), which runs down first and inactivates in a Ca2+-dependent...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200008210-00032

    authors: Rispoli G,Martini M,Rossi ML,Rubbini G,Fesce R

    更新日期:2000-08-21 00:00:00

  • Down regulation of nestin by TGF-beta or serum in SFME cells accompanies differentiation into astrocytes.

    abstract::The serum-free mouse embryo (SFME) cell line, derived from 16-day-old mouse embryos in medium in which serum was replaced by growth factors and other supplements, has been cultured for more than 200 generations. SFME cells are nontumorigenic, lack gross chromosomal abnormalities, and display characteristics of CNS pro...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199408150-00011

    authors: Loo DT,Althoen MC,Cotman CW

    更新日期:1994-08-15 00:00:00

  • Functional compensation of increasing memory encoding demands in the hippocampus.

    abstract::The hippocampus is well known to contribute to episodic memory encoding. Here we used functional magnetic resonance imaging to investigate the hippocampal response to exponentially varying encoding demands while forming associations between faces and names. We found that only the left hippocampus exhibited a stepped m...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283340d36

    authors: Ulrich M,Jonas C,Grön G

    更新日期:2010-01-06 00:00:00

  • Brain activity during expectancy of emotional stimuli: an fMRI study.

    abstract::We studied the neural activation associated with the expectancy of emotional stimuli using whole brain fMRI. Fifteen healthy subjects underwent fMRI scanning during which they performed a warned reaction task using emotional pictures carrying pleasant, unpleasant, or neutral content. The task involved an expected or u...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200301200-00010

    authors: Ueda K,Okamoto Y,Okada G,Yamashita H,Hori T,Yamawaki S

    更新日期:2003-01-20 00:00:00

  • Impaired visual search in dyslexia relates to the role of the magnocellular pathway in attention.

    abstract::We tested the hypothesis that in a cluttered visual scene, the magnocellular (M) pathway is crucial for focusing attention serially on the objects in the field. Since developmental dyslexia is commonly associated with an M pathway deficit, we compared reading impaired children and age-matched normal readers in a searc...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199904260-00024

    authors: Vidyasagar TR,Pammer K

    更新日期:1999-04-26 00:00:00

  • Formant transition-specific adaptation by lipreading of left auditory cortex N1m.

    abstract::To test for the feature specificity of adaptation of auditory-cortex magnetoencephalographic N1m responses to phonemes during lipreading, we presented eight healthy volunteers with a simplified sine-wave first-formant (F1) transition shared by /ba/, /ga/, and /da/, and a continuum of second-formant (F2) transitions co...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f36f7a

    authors: Jääskeläinen IP,Kauramäki J,Tujunen J,Sams M

    更新日期:2008-01-08 00:00:00

  • Electrophysiological evidence that top-down knowledge controls working memory processing for subsequent visual search.

    abstract::Items in working memory guide visual attention toward a memory-matching object. Recent studies have shown that when searching for an object this attentional guidance can be modulated by knowing the probability that the target will match an item in working memory. Here, we recorded the P3 and contralateral delay activi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000545

    authors: Kawashima T,Matsumoto E

    更新日期:2016-03-23 00:00:00

  • Size-invariant representation of face in infant brain: an fNIRS-adaptation study.

    abstract::We studied whether 5-month-old to 8-month-old infants process faces in a size-invariant manner by applying the fNIRS-adaptation paradigm used in our previous study. We used near-infrared spectroscopy to measure hemodynamic responses in the temporal regions of infants' brains during the repeated presentation of an iden...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32835a4b86

    authors: Kobayashi M,Otsuka Y,Kanazawa S,Yamaguchi MK,Kakigi R

    更新日期:2012-12-05 00:00:00

  • Brain stem energy metabolism response to acute hypoxia in anaesthetized rats: a 31P NMR study.

    abstract::Mammals react to acute hypoxia with an initial augmentation and a secondary depression of the respiratory rhythm generated by brain stem neuronal networks. To investigate the cytosolic level of energy rich phosphorus metabolites during these responses, we developed 31P nuclear magnetic resonance spectroscopy of the br...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Piérard C,Champagnat J,Denavit-Saubie M,Gillet B,Beloeil JC,Guezennec CY,Barrère B,Pérès M

    更新日期:1995-12-29 00:00:00

  • Differential distributions of parvalbumin-positive interneurons in the sulci and gyri of the adult ferret cerebral cortex.

    abstract::Although accumulating evidence suggests that there are significant anatomical and histological differences between the sulci and gyri of the cerebral cortex, whether there is a difference in the distribution of interneurons between the two cortical regions remains largely unknown. In this study, we systematically comp...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001309

    authors: Gao JT,Liu Y,Gong D,Feng XM,Wan P,Luo XF,Zhu WH,Hou JC,Lv SJ

    更新日期:2019-10-16 00:00:00

  • Auditory temporal resolution in children assessed by magnetoencephalography.

    abstract::By means of magnetoencephalography we investigated the auditory-evoked fields (AEFs) elicited by broadband noise bursts in a gap-detection paradigm in children. AEFs of 16 healthy children (mean age 8.7 years) were recorded while they passively listened to 100-ms white-noise bursts with temporal gaps of 3, 6, 10 and 3...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f0b6e2

    authors: Diedler J,Pietz J,Bast T,Rupp A

    更新日期:2007-10-29 00:00:00

  • Semantic acquisition without memories: evidence from transient global amnesia.

    abstract::Transient global amnesia (TGA), characterised by a profound anterograde amnesia, is a model of interest to study the acquisition of novel meanings independent of episodic functioning. Three patients were tested during a TGA attack, two in the early recovery phase and the third during the acute phase of TGA, with a sem...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200112040-00052

    authors: Guillery B,Desgranges B,Katis S,de la Sayette V,Viader F,Eustache F

    更新日期:2001-12-04 00:00:00

  • Role of exosomes induced by remote ischemic preconditioning in neuroprotection against cerebral ischemia.

    abstract::Remote ischemic preconditioning (RIPC) is an effective regimen for neuroprotection in ischemic stroke. Exosomes are extracellular vesicles released into the blood, where they can transfer signals throughout the body. Several studies have demonstrated that RIPC leads to many changes in circulating exosomes. However, th...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001280

    authors: Li Y,Ren C,Li H,Jiang F,Wang L,Xia C,Ji X

    更新日期:2019-08-14 00:00:00