Abstract:
:An entry of Ca2+ into postsynaptic sites may play a role in the induction of long-term potentiation (LTP) of synaptic transmission in the visual cortex. To test this hypothesis, a Ca(2+)-chelator was injected into layer II/III neurons of sliced visual cortex obtained from young rats, and excitatory postsynaptic potentials (EPSPs) of these cells to test stimulation of the white matter were observed before and after tetanic stimulation of the same site. To confirm the effectiveness of the tetanus, field potentials reflecting the activities of many cells were recorded with another extracellular electrode. The chelator injection led to long-term depression (LTD) of EPSPs following tetanic stimuli which simultaneously induced LTP of field potentials derived from unchelated cells in most of the slices tested. This suggests that a low concentration of post-synaptic, free Ca2+, when associated with tetanic inputs, may lead to LTD while a rise of Ca2+ may lead to LTP.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kimura F,Tsumoto T,Nishigori A,Yoshimura Ydoi
10.1097/00001756-199009000-00018subject
Has Abstractpub_date
1990-09-01 00:00:00pages
65-8issue
1eissn
0959-4965issn
1473-558Xjournal_volume
1pub_type
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