Abstract:
:The H-Tx rat is a polygenic inherited model of hydrocephalus. In order to identify disease-specific biomarkers associated with congenital hydrocephalus, comparative proteomic analysis was used to screen cerebellum proteins in H-Tx rats at 1 day after birth. Seven proteins showed significant changes in hydrocephalic H-Tx rats compared with Sprague-Dawley and normal H-Tx rats, including HMG-1, CDCrel-1A, mitochondrial ATP synthase, ERp29, NADP+-ICDH, CCT beta and gamma. This indicates that the hydro-cephalus in H-Tx rats may be the result of a panel of proteins. In particular, the presence of HMG-1 and lack of CDCrel-1 in hydrocephalic H-Tx rats suggests that the use of two protein markers will provide further insight with respect to congenital hydrocephalus.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Li X,Miyajima M,Mineki R,Taka H,Murayama K,Arai Hdoi
10.1097/00001756-200504250-00011subject
Has Abstractpub_date
2005-04-25 00:00:00pages
571-4issue
6eissn
0959-4965issn
1473-558Xpii
00001756-200504250-00011journal_volume
16pub_type
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