Differential expression of Group I metabotropic glutamate receptors in motoneurons at low and high risk for degeneration in ALS.

abstract：:To observe sequential stages in tactile pattern discrimination and their modification with and without attention, we used whole-head anatomically constrained magnetoencephalography to spatiotemporally map brain responses. Eight, normal, right-handed participants discriminated between two patterns presented on the palm...

journal_title：Neuroreport

authors： Reed CL,Hagler DJ Jr,Marinkovic K,Dale A,Halgren E

更新日期：2009-07-01 00:00:00

abstract：:Orienting attention to a spatial location facilitates responding to a subsequent target at that location, but inhibits the response if attention is oriented away from that location before the target appears there. This inhibitory effect of attention re-orienting, called inhibition of return (IOR), occurs in vision, he...

journal_title：Neuroreport

authors： Prime DJ,Tata MS,Ward LM

更新日期：2003-03-03 00:00:00

abstract：:Scanning laser-Doppler flowmetry (SLDF) combines laser-Doppler flowmetry and laser scanning to provide images of cerebral blood flow (CBF) with high spatial and temporal resolution. We investigated the contribution of single vascular elements to the local increase of CBF accompanying increased neuronal activity in hal...

journal_title：Neuroreport

authors： Akgören N,Lauritzen M

更新日期：1999-11-08 00:00:00

abstract：:This review paper on visual mismatch negativity (MMN), an event-related brain potential component, provides arguments in favor of its theoretical importance in visual cognitive sciences. We propose that (a) previous visual MMN findings can be regarded as ample evidence for the existence of unintentional prediction abo...

journal_title：Neuroreport

authors： Kimura M,Schröger E,Czigler I

更新日期：2011-10-05 00:00:00

abstract：:Acid-sensing ion channels (ASICs) constitute a branch of the super-gene family of amiloride-sensitive sodium channels. So far five different ASICs have been cloned from mammalian tissues. They are activated by a drop of extracellular pH but differ with respect to effective agonist concentration, desensitization and mR...

journal_title：Neuroreport

authors： Gründer S,Geissler HS,Bässler EL,Ruppersberg JP

更新日期：2000-06-05 00:00:00

abstract：:Peripheral sensorineural hearing loss is a very common inner ear disorder affecting nearly 10% of the population. At present there is no cure for this disorder but gene therapy has been suggested as a potentially effective method for clinical treatment in the future. Thus we investigated the effectiveness of adenovira...

journal_title：Neuroreport

authors： Li Duan M,Bordet T,Mezzina M,Kahn A,Ulfendahl M

更新日期：2002-07-19 00:00:00

abstract：:Bicuculline- and baclofen-insensitive GABA receptors (GABAC receptors) on bipolar cells acutely dissociated from carp retina were investigated with using the whole-cell patch-clamp recording technique. The currents of these cells mediated by GABAC receptors showed striking desensitization, even at low concentrations o...

journal_title：Neuroreport

authors： Han MH,Li Y,Yang XL

更新日期：1997-04-14 00:00:00

abstract：:As treatment of ischemic stroke remains a challenge with respect to the failure of numerous neuroprotective attempts, there is an ongoing need for better understanding of pathophysiological mechanisms causing tissue damage. Although ischemic outcomes have been studied extensively at the cellular and molecular level us...

journal_title：Neuroreport

authors： Michalski D,Härtig W,Krueger M,Hobohm C,Käs JA,Fuhs T

更新日期：2015-07-08 00:00:00

abstract：:Hyperactivity of the hypothalamic-pituitary-adrenal axis and impairment of the central corticotropin-releasing factor system are factors in the pathogenesis of depression. Though several antagonists of the corticotropin-releasing factor 1 receptor were effective in the recognized behavioral tests for antidepressant ac...

journal_title：Neuroreport

authors： Wang XB,Zhang YQ,Xue RR,Yang ZZ,Zhang XF

更新日期：2020-01-08 00:00:00

abstract：:Recent studies have shown the nutrient-sensing systems transmitting nutritive information from the gut to the brain. However neural activity evoked by ingested dietary nutrients has not been investigated adequately. Using functional magnetic resonance imaging, we demonstrated that rat forebrain responded to intragastr...

journal_title：Neuroreport

authors： Tsurugizawa T,Kondoh T,Torii K

更新日期：2008-07-16 00:00:00

abstract：:The whole-cell patch clamp technique was used to investigate the actions of the opioid agonist U50488H on Ca2+ and K+ currents in differentiated NG108-15 cells. U50488H (5-50 microM) caused a concentration-dependent, reversible inhibition of high voltage-activated Ca2+ currents which persisted in the presence of nifed...

journal_title：Neuroreport

authors： Carpenter E,Gent JP,Peers C

更新日期：1996-07-29 00:00:00

abstract：:Flurothyl kindling initiates a time-dependent process that results in a facilitated propagation from the forebrain to the brainstem seizure system and in an increase in the complexity of behavioral seizure expression. We investigated the involvement of the ventromedial nucleus of the hypothalamus (VMH) in mediating th...

journal_title：Neuroreport

authors： Ferland RJ,Applegate CD

更新日期：1998-11-16 00:00:00

abstract：:To test for the feature specificity of adaptation of auditory-cortex magnetoencephalographic N1m responses to phonemes during lipreading, we presented eight healthy volunteers with a simplified sine-wave first-formant (F1) transition shared by /ba/, /ga/, and /da/, and a continuum of second-formant (F2) transitions co...

journal_title：Neuroreport

authors： Jääskeläinen IP,Kauramäki J,Tujunen J,Sams M

更新日期：2008-01-08 00:00:00

abstract：:We injected neural tracers into the lateral funiculus of the spinal cord in order to relate the sites of origin of the spinal projections from the mesial cortical surface with the cytoarchitectonic organization of this region. We found a close correlation between the origin sites and density of corticospinal projectio...

journal_title：Neuroreport

authors： Luppino G,Matelli M,Camarda R,Rizzolatti G

更新日期：1994-12-20 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in drug tolerance and regulating pain. The purpose of the present study is to explore the regulatory mechanism of miR-124-3p on dezocine tolerance against pain in a rat model. The expression of miR-124-3p and TRAF6 in spinal cord of rats was detected by quantitative reverse-tran...

journal_title：Neuroreport

authors： Huo Y,Zhang K,Zhang T,Han Y,Hu Z

更新日期：2021-01-06 00:00:00

abstract：:Male Bengalese finches sing complex song sequences during courtship. To examine the female perception of sequence complexity, we tested female auditory processing with respect to sequential differences in the caudomedial nidopallium and caudomedial mesopallium. Repeated song presentations caused lower expression of th...

journal_title：Neuroreport

authors： Kato Y,Kato M,Hasegawa T,Okanoya K

更新日期：2010-04-21 00:00:00

abstract：:The ATP-gated cation channel P2X3 is expressed selectively by rat sensory neurones, and may play a role in nociception by binding ATP released from damaged or inflamed tissues. However, the distribution of this channel in human sensory neurons is not known. Using a specific antibody, we have demonstrated intense P2X3 ...

journal_title：Neuroreport

authors： Yiangou Y,Facer P,Birch R,Sangameswaran L,Eglen R,Anand P

更新日期：2000-04-07 00:00:00

abstract：:Dysfunctional glutamate neurotransmission has been implicated in the pathophysiology of schizophrenia. Abnormal expressions in schizophrenia of ionotropic glutamate receptors (iGluRs) and the proteins that regulate their trafficking have been found to be region and subunit specific in brain, suggesting that abnormal t...

journal_title：Neuroreport

authors： Tucholski J,Simmons MS,Pinner AL,McMillan LD,Haroutunian V,Meador-Woodruff JH

更新日期：2013-08-21 00:00:00

abstract：:There is abundant psychophysical evidence in humans suggesting the existence of parallel pathways subserving different aspects of vision. However, there is little direct proof of the neural structures underlying the two pathways. We present direct anatomical evidence that in the normal human optic tract fibres are seg...

journal_title：Neuroreport

authors： Tassinari G,Campara D,Balercia G,Chilosi M,Martignoni G,Marzi CA

更新日期：1994-07-21 00:00:00

abstract：:Event-related potential studies have reported error-related negativity following both error commission and feedback indicating errors or monetary loss. The present study examined whether error-related negativities could be elicited by a predictive cue presented prior to both the decision and subsequent feedback in a g...

journal_title：Neuroreport

authors： Dunning JP,Hajcak G

更新日期：2007-11-19 00:00:00

abstract：:Microglial activation is a prominent feature of affected brain areas in multiple system atrophy. Microglia express proinflammatory peptides, which may be a result of activation of nuclear factor-KB. We investigated the nuclear presence of RelA, the 65 kDa subunit of the NF-KB/RelA family in striatum and brain stem of ...

journal_title：Neuroreport

authors： Schwarz SC,Seufferlein T,Liptay S,Schmid RM,Kasischke K,Foster OJ,Daniel S,Schwarz J

更新日期：1998-09-14 00:00:00

abstract：:Inhibition, the process that overrides and reverses the execution of a thought, action, or emotion, is important in daily life. Sixteen healthy volunteers performed a parametrically modulated motor inhibition task during functional magnetic resonance imaging. Two results were observed: (1) increased error-related ante...

journal_title：Neuroreport

authors： Matthews SC,Simmons AN,Arce E,Paulus MP

更新日期：2005-05-12 00:00:00

abstract：:We recorded multiple unit activities of the CA1 region of the intermediate hippocampus and prelimbic area of the prefrontal cortex, and evoked responses in the prefrontal cortex by hippocampal stimulation in urethane-anesthetized rats. The multiple unit activities between these regions showed significant peaks of cros...

journal_title：Neuroreport

authors： Fujiwara SE,Akema T,Izaki Y

更新日期：2010-10-27 00:00:00

abstract：:We can report, that by the use of indirect immunofluorescence techniques, that rat spinal motoneurons contain galanin-like immunoreactivity (LI). Furthermore, that galanin and calcitonin gene-related peptide (CGRP)-LI coexist in a number of spinal motoneurons. Co-localization could be demonstrated as thoracic, lumbar ...

journal_title：Neuroreport

authors： Johnson H,Hökfelt T,Ulfhake B

更新日期：1992-04-01 00:00:00

abstract：:GLAST is a glial glutamate transporter; mRNA for a splice variant, GLAST1a, which lacks exon 3, has previously been identified. To detect GLAST1a protein, we generated antibodies against a peptide sequence encompassing the splice site. We demonstrate by Western blotting and immunocytochemistry the expression of GLAST1...

journal_title：Neuroreport

authors： Macnab LT,Williams SM,Pow DV

更新日期：2006-12-18 00:00:00

abstract：:The present study was designed to test the hypothesis that nitric oxide (NO) plays a role in 2-deoxy-D-glucose (2-DG)-induced hypothermia. The body temperature of awake, unrestrained rats was measured before and after the administration of 2-DG, or N(G)-nitro-L-arginine methyl ester (L-NAME; a non-selective NOS inhibi...

journal_title：Neuroreport

authors： Carnio EC,Almeida MC,Fabris G,Branco LG

更新日期：1999-09-29 00:00:00

abstract：:As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TR beta (Thrb(tm1/tm1)) and is marked by early onset and persistence, thereby differing from mouse str...

journal_title：Neuroreport

authors： Ng L,Pedraza PE,Faris JS,Vennström B,Curran T,Morreale de Escobar G,Forrest D

更新日期：2001-08-08 00:00:00

abstract：:The role of dopaminergic pathways in the retina in controlling the functional state of the pineal was investigated. Dopaminergic agents were injected into the eyes of dark-adapted chickens which were maintained in the dark. Changes in the activity of N-acetyltransferase (NAT) in the retina and pineal were then monitor...

journal_title：Neuroreport

authors： Morgan IG,Boelen MK,Miethke P

更新日期：1995-02-15 00:00:00

abstract：:We examined effects of trial averaging upon spatial extent, spatial topography, and temporal properties of fMRI activation. Two subjects participated in an event-related visual stimulation design. There was an exponential relation between number of trials and spatial extent, such that additional trials identified, on ...

journal_title：Neuroreport

authors： Huettel SA,McCarthy G

更新日期：2001-08-08 00:00:00

abstract：:To determine whether physical match between studied and tested items influences blood flow increases in the hippocampal formation associated with recognition memory, positron emission tomography (PET) was used to measure changes in regional cerebral blood flow while healthy volunteers made old/new judgements about lin...

journal_title：Neuroreport

authors： Schacter DL,Uecker A,Reiman E,Yun LS,Bandy D,Chen K,Cooper LA,Curran T

更新日期：1997-12-22 00:00:00