Forebrain activation induced by postoral nutritive substances in rats.

Abstract:

:Recent studies have shown the nutrient-sensing systems transmitting nutritive information from the gut to the brain. However neural activity evoked by ingested dietary nutrients has not been investigated adequately. Using functional magnetic resonance imaging, we demonstrated that rat forebrain responded to intragastric administration of glucose, L-glutamate, and NaCl. These dietary nutrients led to a significant activation in the forebrain regions including nucleus accumbens, hypothalamic area, and limbic system with different timings. These data indicate that several forebrain regions have important roles on perception and process of postingestive nutrient information.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Tsurugizawa T,Kondoh T,Torii K

doi

10.1097/WNR.0b013e328307c414

subject

Has Abstract

pub_date

2008-07-16 00:00:00

pages

1111-5

issue

11

eissn

0959-4965

issn

1473-558X

pii

00001756-200807160-00006

journal_volume

19

pub_type

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