Cognitive sequence processing and syntactic comprehension in schizophrenia.

Abstract:

:It has been repeatedly demonstrated that schizophrenic patients are impaired in the comprehension of sentences with complex syntax. We investigated the hypothesis that this syntactic comprehension impairment in schizophrenia is not a purely linguistic dysfunction, but rather the reflection of a cognitive sequence processing impairment that is revealed as task complexity increases. We tested 10 schizophrenic patients using a standard measure of syntactic comprehension, and a non-linguistic sequence processing task, both of which required simple and complex transformation processing. Patients' performance impairment on the two tasks was highly correlated (r2 = 0.84), and there was a significant effect for complexity, independent of the task. These results are quite similar to those of aphasic patients with left hemisphere lesions. This suggests that syntactic comprehension deficits in schizophrenia reveal the dysfunction of cognitive sequence processing mechanisms that can be expressed both in linguistic and non-linguistic sequence tasks.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Lelekov T,Franck N,Dominey PF,Georgieff N

doi

10.1097/00001756-200007140-00017

subject

Has Abstract

pub_date

2000-07-14 00:00:00

pages

2145-9

issue

10

eissn

0959-4965

issn

1473-558X

journal_volume

11

pub_type

杂志文章
  • Mutational characterization of ATP7B gene in 103 Wilson's disease patients from Southern China: identification of three novel mutations.

    abstract::Wilson's disease (WD) is an autosomal recessive inheritance disorder of copper metabolism due to mutations in the ATP7B gene. The distribution of ATP7B gene mutations is diverse in different population. This study aimed to examine the genotypes of the ATP7B mutant alleles in WD patients from Southern China. Genomic DN...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000216

    authors: Wei Z,Huang Y,Liu A,Diao S,Yu Q,Peng Z,Hong M

    更新日期:2014-10-01 00:00:00

  • N- and C-terminal substance P fragments: differential effects on striatal [3H]substance P binding and NK1 receptor internalization.

    abstract::N- and C-terminal substance P (SP) fragments increase striatal dopamine outflow at nanomolar concentrations. This contrasts with their low affinity for NK1 receptors. To explore this discrepancy, we investigated the interaction of SP and SP fragments with NK1 sites in fresh striatal slices, the same model used in the ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199907130-00038

    authors: Michael-Titus AT,Blackburn D,Connolly Y,Priestley JV,Whelpton R

    更新日期:1999-07-13 00:00:00

  • Neural correlates of expectation of musical termination structure or cadence.

    abstract::Music is an essential communication tool that can convey emotional information. Segmentation of a sound stream of music at event boundaries is necessary for identification and extraction of musical context and features. To investigate recognition of music termination structure, or cadence, we composed music sequences ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000160

    authors: Hoshi-Shiba R,Furukawa K,Okanoya K

    更新日期:2014-07-09 00:00:00

  • Preferential expression of IGF-I in small DRG neurons and down-regulation following injury.

    abstract::In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy. We demonstrate that IGF-I and its receptor are prefe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200209160-00016

    authors: Craner MJ,Klein JP,Black JA,Waxman SG

    更新日期:2002-09-16 00:00:00

  • Effects of musical training on speech-induced modulation in corticospinal excitability.

    abstract::We investigated the effect of previous musical training on lateralization of language as indexed by the effects of reading aloud on the modulation of motor evoked potentials (MEPs) induced in the first dorsal interosseus muscles (FDI) by transcranial magnetic stimulation (TMS) of the primary motor cortex. We studied 1...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200205070-00033

    authors: Lin KL,Kobayashi M,Pascual-Leone A

    更新日期:2002-05-07 00:00:00

  • Increased levels of TrkA in the regenerating retinal ganglion cells of fish.

    abstract::Retinal ganglion cells of the fish have the spontaneous capacity to regenerate after nerve crush, a phenomenon known to be facilitated by nerve growth factor (NGF). We have studied the high-affinity NGF receptor TrkA, during the regeneration of the tench (Tinca tinca L.) optic nerve, using immunocytochemical technique...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199810260-00014

    authors: Vecino E,Caminos E,Becker E,Rudkin BB,Evan GI,Martín-Zanca D

    更新日期:1998-10-26 00:00:00

  • Cloning and characterization of mouse GABA(C) receptor subunits.

    abstract::Retinal gamma-aminobutyric acid type C (GABA[C]) receptors are believed to consist of rho subunits. The pharmacological properties of GABA(C) receptors appear to vary among different species. Since the mouse is an important model for gene targeting and behavioral studies, this study was aimed at cloning rho subunits i...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199801260-00010

    authors: Greka A,Koolen JA,Lipton SA,Zhang D

    更新日期:1998-01-26 00:00:00

  • Multiple integration of input and output in the cortex.

    abstract::We inserted microelectrodes in eye movement-evoking cortices (EMECs) of cats and examined whether neurones in the EMECs received sensory input from guide signals and fired prior to saccades. The five EMECs were the medial wall of the hemisphere under the cruciate sulcus, the medical and lateral bank of the presylvian ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199610020-00024

    authors: Tamai Y,Kimura A

    更新日期:1996-10-02 00:00:00

  • NMDA receptors mediate neuronal burst firing in rat somatosensory cortex in vivo.

    abstract::Two patterns of neuronal firing, bursting and regular spiking, are observed in the somatosensory cortex of anesthetized rats. The effects of excitatory amino acid receptor agonists and antagonists on these discharge types have been examined in vivo, in order to assess their involvement in the generation of such firing...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199306000-00034

    authors: Kobayashi T,Nagao T,Fukuda H,Hicks TP,Oka JI

    更新日期:1993-06-01 00:00:00

  • Presenilin-1 polymorphism and amyloid beta-protein deposition in fatal head injury.

    abstract::Approximately 30% of patients with fatal head injuries have deposits of amyloid beta-protein (A beta); these are predominantly individuals carrying the epsilon 4 allele of apolipoprotein E (apoE). A beta deposition occurs in Alzheimer's disease (AD), for which approximately 50% of the genetic risk is attributed to apo...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199612200-00010

    authors: Zunarelli E,Nicoll JA,Graham DI

    更新日期:1996-12-20 00:00:00

  • Detection of verbal discordances during sleep.

    abstract::We used an electrophysiological marker of linguistic discordance, the N400 wave, to investigate how linguistic and pseudo-linguistic stimuli are categorised during sleep as compared to waking. During wakefulness, signs of discordance detection were, as expected, greater for pseudo-words than for real but semantically ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200207190-00026

    authors: Perrin F,Bastuji H,Garcia-Larrea L

    更新日期:2002-07-19 00:00:00

  • Nuclear translocation of DJ-1 protects adult neuronal stem cells in an MPTP mouse model of Parkinson's disease.

    abstract::DJ-1, originally identified as an oncogene product, is involved in multiple processes, including cellular transformation, the oxidative stress response, and transcriptional regulation. We had previously found that DJ-1 was closely associated with the proliferation and differentiation of cultured neuronal stem cells. I...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000956

    authors: Sun Y,Wang Y,Zhao X,Pu X

    更新日期:2018-03-07 00:00:00

  • Induction of ischemic tolerance and antioxidant activity by brief focal ischemia.

    abstract::Three forms of non-injurious ischemic preconditioning were tested for their effects on endogenous antioxidant activity and subsequent ischemic injury. Test ischemia alone, consisting of 1 h occlusion of both carotid arteries (BCAs) and one middle cerebral artery (MCA), elicited an average volume of cerebral infarction...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199703030-00008

    authors: Toyoda T,Kassell NF,Lee KS

    更新日期:1997-03-03 00:00:00

  • External modulation of visual perception in humans.

    abstract::Static and dynamic contrast sensitivities (sCS and dCS) were evaluated before, during, immediately after and 10 min after anodal and cathodal transcranial direct current stimulation (tDCS) applied to the occipital cortex of 15 healthy subjects. Using 4 c/d spatial and 4 Hz temporal frequencies significant sCS and dCS ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200111160-00036

    authors: Antal A,Nitsche MA,Paulus W

    更新日期:2001-11-16 00:00:00

  • Effects of ensheathing cells transplanted into photochemically damaged spinal cord.

    abstract::Transplantation of olfactory ensheathing cells (OECs) into photochemically damaged rat spinal cord diminished astrocyte reactivity and parenchyma cavitation. The photochemical lesion performed at T12--L1 resulted in severe damage to the spinal cord, so that during the first 15 days postoperation all rats dragged their...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200108080-00005

    authors: Verdú E,García-Alías G,Forés J,Gudiño-Cabrera G,Muñetón VC,Nieto-Sampedro M,Navarro X

    更新日期:2001-08-08 00:00:00

  • Effects of baicalin on diabetic neuropathic pain involving transient receptor potential vanilloid 1 in the dorsal root ganglia of rats.

    abstract::Diabetic peripheral neuropathy is the most common complication of diabetes mellitus and leads to sensory symptoms, including diabetic neuropathic pain (DNP). DNP is a major public health problem because it has a considerable impact on life quality of diabetes mellitus patients. Therefore, development of novel effectiv...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001138

    authors: Li P,Xiong DL,Sun WP,Xu SY

    更新日期:2018-12-05 00:00:00

  • Modulation of P-CREB and expression of c-fos in cochlear nucleus and superior olive following electrical intracochlear stimulation.

    abstract::Investigating activity-dependent plasticity in the auditory brain stem of the adult rat, we observed that electrical intracochlear stimulation led to a tonotopically localized modulation of the phosphorylation of the cAMP response element binding protein (CREB) and an equally localized expression of the immediate earl...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200103260-00050

    authors: Illing RB,Michler SA

    更新日期:2001-03-26 00:00:00

  • Perirhinal cortex lesions in rats disrupt performance in a spatial DNMS task.

    abstract::Rats with bilateral electrolytic lesions of the perirhinal cortex and sham operated control rats were tested in a spatially guided, delayed non match to sample task. Although perirhinal lesioned animals showed no deficit in acquisition of the task, a performance deficit was observed across longer delay intervals. Thes...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Wiig KA,Bilkey DK

    更新日期:1994-06-27 00:00:00

  • Corpus callosum: musician and gender effects.

    abstract::Previously we found that musicians have significantly larger anterior corpus callosum (CC). In the current study, we intended to replicate and extend our previous results using a new and larger sample of gender-matched subjects (56 right-handed professional musicians and 56 age- and handedness-matched controls). We fo...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200302100-00009

    authors: Lee DJ,Chen Y,Schlaug G

    更新日期:2003-02-10 00:00:00

  • Calbindin-D28K, parvalbumin and calretinin in primate lower motor neurons.

    abstract::It has been suggested that lower motor neurons containing calcium-binding proteins (CBP) may be resistant to degeneration in motor neuron disease. The testing of this hypothesis is hampered by lack of comprehensive information regarding the presence of CBPs in motor neurons. To address this shortcoming, we investigate...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200403010-00012

    authors: Fahandejsaadi A,Leung E,Rahaii R,Bu J,Geula C

    更新日期:2004-03-01 00:00:00

  • Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury.

    abstract::Activity of calpains and caspase-3 inferred from proteolysis of the cytoskeletal protein alpha-spectrin into signature spectrin breakdown products (SBDPs) was used to provide the first systematic and simultaneous comparison of changes in activity of these two families of cysteine proteases after traumatic brain injury...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199808030-00002

    authors: Pike BR,Zhao X,Newcomb JK,Posmantur RM,Wang KK,Hayes RL

    更新日期:1998-08-03 00:00:00

  • Evidence for inert gas narcosis mechanisms in the occurrence of psychotic-like episodes at pressure environment.

    abstract::Psychotic-like episodes in divers exposed to high pressure have been attributed to either the high-pressure neurological syndrome, confinement in pressure chamber, the subject's personality, or the addition of nitrogen or hydrogen to the basic helium-oxygen breathing mixture used for deep diving. Alternatively, it is ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199503000-00027

    authors: Abraini JH

    更新日期:1995-03-07 00:00:00

  • Retinal ganglion cell axons regenerate in the presence of intact sensory fibres.

    abstract::A novel allograft paradigm was used to test whether adult mammalian central axons regenerate within a peripheral nerve environment containing intact sensory axons. Retinal ganglion cell axon regeneration was compared following anastomosis of dorsal root ganglia grafts or conventional peripheral nerve grafts to the adu...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000195668.07467.a8

    authors: King C,Bartlett C,Sauvé Y,Lund R,Dunlop S,Beazley L

    更新日期:2006-02-06 00:00:00

  • Botulinum toxin type A reduces the expression of transient receptor potential melastatin 3 and transient receptor potential vanilloid type 4 in the trigeminal subnucleus caudalis of a rat model of trigeminal neuralgia.

    abstract::This study was designed to investigate the expression of transient receptor potential melastatin 3 (TRPM3) and transient receptor potential vanilloid type 4 (TRPV4) in the trigeminal spinal subnucleus caudalis of a rat model of trigeminal neuralgia (TN). The influence of botulinum toxin type A (BTX-A) on the expressio...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001268

    authors: Zhang Y,Su Q,Lian Y,Chen Y

    更新日期:2019-07-03 00:00:00

  • Eye instability induced by vestibular stimulation in rabbits.

    abstract::The slow compensatory phases of the vestibulo-ocular reflex (VOR) in the rabbit tend to drift and the drift reverses the direction. This periodic alternating drift (PAD) has two peculiar characteristics: (1) it is induced by sinusoidal vestibular stimulation in naive animals, being evoked immediately after stimulus on...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200107030-00017

    authors: Ferraresi A,Azzena GB,Troiani D

    更新日期:2001-07-03 00:00:00

  • Correlations, feature-binding and population coding in primary visual cortex.

    abstract::To test the hypothesis that correlated neuronal activity serves as the neuronal code for visual feature binding, we applied information theory techniques to multiunit activity recorded from pairs of V1 recording sites in anaesthetised cats while presenting either single or separate bar stimuli. We quantified the roles...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000073681.00308.9c

    authors: Golledge HD,Panzeri S,Zheng F,Pola G,Scannell JW,Giannikopoulos DV,Mason RJ,Tovée MJ,Young MP

    更新日期:2003-05-23 00:00:00

  • ApoE associated with lipid has a reduced capacity to inhibit beta-amyloid fibril formation.

    abstract::Apolipoprotein E (apoE) and the beta-amyloid peptide are both found in the senile plaques associated with Alzheimer's disease. Several studies have recently determined that apoE can prevent beta-amyloid fibril (Abetaf) formation in vitro. In vivo, apoE is normally associated with a lipid source. We show that both reco...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199810050-00031

    authors: Beffert U,Poirier J

    更新日期:1998-10-05 00:00:00

  • Semantic acquisition without memories: evidence from transient global amnesia.

    abstract::Transient global amnesia (TGA), characterised by a profound anterograde amnesia, is a model of interest to study the acquisition of novel meanings independent of episodic functioning. Three patients were tested during a TGA attack, two in the early recovery phase and the third during the acute phase of TGA, with a sem...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200112040-00052

    authors: Guillery B,Desgranges B,Katis S,de la Sayette V,Viader F,Eustache F

    更新日期:2001-12-04 00:00:00

  • Dopamine modulates striatal response to reward and punishment in patients with Parkinson's disease: a pharmacological challenge fMRI study.

    abstract::It is well established that Parkinson's disease leads to impaired learning from reward and enhanced learning from punishment. The administration of dopaminergic medications reverses this learning pattern. However, few studies have investigated the neural underpinnings of these cognitive processes. In this study, using...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000970

    authors: Argyelan M,Herzallah M,Sako W,DeLucia I,Sarpal D,Vo A,Fitzpatrick T,Moustafa AA,Eidelberg D,Gluck M

    更新日期:2018-05-02 00:00:00

  • Two classes of potassium currents in Xenopus muscle cells in young cultures.

    abstract::The aim of the present study was to determine if both inactivating and non-inactivating potassium currents occur in skeletal muscle cells at early times in culture. Whole cell current was recorded from embryonic muscle cells within 4-10 h of plating. We found that in the cells which had an outward current, half had a ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199204000-00007

    authors: Moody-Corbett F,Gilbert R

    更新日期:1992-04-01 00:00:00