Calbindin-D28K, parvalbumin and calretinin in primate lower motor neurons.

Abstract:

:It has been suggested that lower motor neurons containing calcium-binding proteins (CBP) may be resistant to degeneration in motor neuron disease. The testing of this hypothesis is hampered by lack of comprehensive information regarding the presence of CBPs in motor neurons. To address this shortcoming, we investigated the distribution of the CBPs calbindin-D28K (CB), parvalbumin (PV) and calretinin (CRT) in lower motor neurons in the normal human and two non-human primates (rhesus monkey and common marmoset) using immunohistochemistry. A variable proportion of motor neurons in cranial nerve motor nuclei contained immunoreactivity for one or more CBPs. A subpopulation of spinal cord alpha-motor neurons was also CBP-positive. Comparison of staining for choline acetyltransferase (ChAT) and CBPs in the human spinal cord demonstrated that approximately 63% of ventral horn motor neurons contained PV, 53% contained CRT and 56% contained CB. CBP immunoreactivity within motor neurons was of variable staining intensity. It remains to be established whether the presence of these CBPs confers protection against the pathogenic mechanisms of motor neuron disease.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Fahandejsaadi A,Leung E,Rahaii R,Bu J,Geula C

doi

10.1097/00001756-200403010-00012

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

443-8

issue

3

eissn

0959-4965

issn

1473-558X

pii

00001756-200403010-00012

journal_volume

15

pub_type

杂志文章
  • Preferential expression of IGF-I in small DRG neurons and down-regulation following injury.

    abstract::In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy. We demonstrate that IGF-I and its receptor are prefe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200209160-00016

    authors: Craner MJ,Klein JP,Black JA,Waxman SG

    更新日期:2002-09-16 00:00:00

  • Autocrine function of erythropoietin in IGF-1-induced erythropoietin biosynthesis.

    abstract::Insulin-like growth factor-1 (IGF-1) and erythropoietin (EPO) are induced in brain cells after brain ischemia and show synergistic neuroprotective effects. In LN215 astrocytoma cells, IGF-1 induced the activation of hypoxia-inducible factor-1, leading to increases in EPO mRNA levels and the secretion of EPO. Interesti...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32831743fb

    authors: Kim I,Kim CH,Yim YS,Ahn YS

    更新日期:2008-11-19 00:00:00

  • Dominance for language and spatial processing: limited capacity of a single hemisphere.

    abstract::Using functional magnetic resonance imaging during word generation and spatial judgement (Landmark task), we investigated how hemispheric specializations for language and spatial processing interact in healthy individuals. We found individuals with atypical, right-hemispheric dominance for language to have more bilate...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200506210-00027

    authors: Jansen A,Flöel A,Menke R,Kanowski M,Knecht S

    更新日期:2005-06-21 00:00:00

  • Effect of galanin on plasma levels of oxytocin and cholecystokinin.

    abstract::Galanin, oxytocin and cholecystokinin (CCK) are peptides that influence feeding behaviour. Galanin has been found to stimulate food intake and oxytocin and CCK have been suggested to be satiety agents. The present study was performed in order to investigate if galanin influences the secretion of oxytocin and CCK as a ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199301000-00002

    authors: Björkstrand E,Hulting AL,Meister B,Uvnäs-Moberg K

    更新日期:1993-01-01 00:00:00

  • Influences of encoding and retrieval on the steady-state visual evoked potential.

    abstract::The steady-state visual evoked potential (SSVEP) is a powerful tool to study basic perceptual functions in the human electroencephalogram (EEG) (e.g. selective attention). The present study aimed at finding support for the SSVEP's sensitivity to higher cognitive functions (e.g. memory). We tagged pictures of meaningle...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283516542

    authors: Martens U,Gert AL,Gruber T

    更新日期:2012-04-18 00:00:00

  • Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue.

    abstract::The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochrome...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199209000-00007

    authors: Chen Y,Getchell ML,Ding X,Getchell TV

    更新日期:1992-09-01 00:00:00

  • Slit2/Robo1 promotes synaptogenesis and functional recovery of spinal cord injury.

    abstract::Neuronal network reconstruction is a pivotal determinant for functional recovery after spinal cord injury (SCI), the process of which includes synaptogenesis. Slit2 protein has been identified as a key regulator of axon regeneration and synapse formation in the vertebrate. Meanwhile, RhoA is the converging cascade of ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000715

    authors: Li Y,Gao Y,Xu X,Shi R,Liu J,Yao W,Ke C

    更新日期:2017-01-18 00:00:00

  • Desensitizing GABAC receptors on carp retinal bipolar cells.

    abstract::Bicuculline- and baclofen-insensitive GABA receptors (GABAC receptors) on bipolar cells acutely dissociated from carp retina were investigated with using the whole-cell patch-clamp recording technique. The currents of these cells mediated by GABAC receptors showed striking desensitization, even at low concentrations o...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199704140-00003

    authors: Han MH,Li Y,Yang XL

    更新日期:1997-04-14 00:00:00

  • LTD and LTP induced by transcranial magnetic stimulation in auditory cortex.

    abstract::Using a system capable of relatively localized and rapidrate transcranial magnetic stimulation (rTMS), evoked trains of complex spikes were studied in rodent auditory cortex. Low rate rTMS from 1 to 10Hz produced a frequency-dependent increase in spike rate. Iterations of rTMS resulted in long-term potentiation (LTP)-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199601310-00035

    authors: Wang H,Wang X,Scheich H

    更新日期:1996-01-31 00:00:00

  • Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats.

    abstract::Menthol is known as an agonist for cold-sensitive transient receptor potential channels (TRPM8) and also as a direct modulator of GABA channels. We examined the effects of menthol on respiratory rhythm generation in the brainstem-spinal cord preparations isolated from newborn rats. Menthol decreased respiratory rhythm...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283405bad

    authors: Tani M,Onimaru H,Ikeda K,Kawakami K,Homma I

    更新日期:2010-12-08 00:00:00

  • Analysis of hippocampal atrophy in alcoholic patients by a Kohonen feature map.

    abstract::We investigated the correlation of hippocampal volume with homocysteine, folate, vitamin B12 and B6 in alcoholic patients and healthy controls applying a Kohonen feature map (KFM) and conventional statistics. Representation of subjects on the KFM suggested an inverse correlation of hippocampal volume with blood levels...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200402090-00031

    authors: Kurth C,Wegerer V,Reulbach U,Lewczuk P,Kornhuber J,Steinhoff BJ,Bleich S

    更新日期:2004-02-09 00:00:00

  • Quantification of TECTA and DFNA5 expression in the developing mouse cochlea.

    abstract::TECTA and DFNA5 are the mouse orthologues of the human deafness-associated genes TECTA and DFNA5. To determine how expression of these genes is regulated during development, relative mRNA abundance was examined in mice by non-radioactive RT-PCR. TECTA mRNA was detected on embryonic day 15 (E15), increased to its highe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200110290-00016

    authors: Maeda Y,Fukushima K,Kasai N,Maeta M,Nishizaki K

    更新日期:2001-10-29 00:00:00

  • Effects of Src kinase inhibition on expression of pro-caspase-2 after brain hypoxia in a piglet animal model.

    abstract::Caspase-2 has features of both initiator and effector caspases. Previously, we have shown that brain hypoxia-induced production of caspases 1, 3, 8, and 9 is Src kinase mediated, a nonreceptor intracellular family of kinases. The present study tests the hypothesis that hypoxia results in increased expression of caspas...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000835

    authors: Angelis D,Delivoria-Papadopoulos M

    更新日期:2017-08-16 00:00:00

  • Over-expression of MBP and PLP messenger RNA in 8-day-old trembler brain.

    abstract::The trembler mouse suffers from a dominantly inherited mutation of the peripheral myelin protein 22 (PMP-22) gene which results in abnormal myelination of the peripheral nervous system. However, the clinical symptoms observed in the mutant suggest abnormalities in the central nervous system. Using the Northern blot te...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199406020-00015

    authors: Bascles L,Bonnet J,Garbay B

    更新日期:1994-06-02 00:00:00

  • BOLD signal response to cocaine varies with sexual receptivity in female rats.

    abstract::Blood oxygen level dependent MRI was used to test whether cocaine-stimulated mesolimbic activity varied with sexual receptivity. Rats were randomly screened for lordotic responses and were then imaged for their responses to centrally administered cocaine. We observed that female rats expressing no lordosis showed a gr...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283416f81

    authors: Febo M,Segarra AC,Stolberg TL,Ferris CF

    更新日期:2011-01-05 00:00:00

  • The pattern and distribution of calcitonin gene-related peptide (CGRP) terminals in the rat dorsal following neonatal peripheral inflammation.

    abstract::Neonatal peripheral inflammation has been shown to alter the neural circuitry of the spinal cord in adult rats. However, the temporal and spatial changes in the distribution of primary afferent terminals immediately following a neonatal inflammatory stimulus remains unclear. In the present study we found that intrapla...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200310270-00007

    authors: Ling QD,Chien CC,Wen YR,Fu WM,Sun WZ

    更新日期:2003-10-27 00:00:00

  • Prenatal stress suppresses cell proliferation in the early developing brain.

    abstract::Although prenatal stress has been repeatedly shown to inhibit adult neurogenesis in the dentate gyrus of offspring, its effects on embryonic and early postnatal brain development are not well described. Here, using the cell proliferation marker 5-bromo-2'-deoxyuridine, we examine for the first time the effect of prena...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000236849.53682.6d

    authors: Kawamura T,Chen J,Takahashi T,Ichitani Y,Nakahara D

    更新日期:2006-10-02 00:00:00

  • Resiliency of cortical neural networks against cascaded failures.

    abstract::Network tools have been extensively applied to study the properties of brain functional and anatomical networks. In this paper, resiliency of Caenorhabditis elegans cortical networks against cascaded failures is studied. To this end, directed network formed by chemical connections and undirected network formed by elec...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000421

    authors: Jalili M

    更新日期:2015-08-19 00:00:00

  • Forebrain activation induced by postoral nutritive substances in rats.

    abstract::Recent studies have shown the nutrient-sensing systems transmitting nutritive information from the gut to the brain. However neural activity evoked by ingested dietary nutrients has not been investigated adequately. Using functional magnetic resonance imaging, we demonstrated that rat forebrain responded to intragastr...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328307c414

    authors: Tsurugizawa T,Kondoh T,Torii K

    更新日期:2008-07-16 00:00:00

  • HU-211, a non-psychotropic cannabinoid, rescues cortical neurones from excitatory amino acid toxicity in culture.

    abstract::The present study examined potential neuroprotective effects of HU-211, a synthetic non-psychotropic cannabinoid with non-competitive NMDA antagonist properties on neurones exposed to various excitotoxins in culture. HU-211 was found to protect neurones from NMDA and quisqualate-induced toxicity but not that produced ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199312000-00013

    authors: Eshhar N,Striem S,Biegon A

    更新日期:1993-12-13 00:00:00

  • Sensory funneling of liminal multiple- point air-puff stimulation produces dramatic reduction in reaction time but relatively invariant P300 somatosensory evoked potential.

    abstract::Sensory funneling of liminal multiple-point air-puff stimulation on the skin was evaluated by measuring somatosensory evoked potentials (SEPs), reaction time (RT) and subjective detection threshold. Single-point air-puffs at the threshold intensity, and 2-point and 3-point air-puffs (10 mm apart) of the same intensity...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199910190-00014

    authors: Hashimoto I,Yoshikawa K,Kimura T

    更新日期:1999-10-19 00:00:00

  • Nitric oxide synthase expressions in rat dorsal root ganglion after a hind limb tourniquet.

    abstract::We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Si...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200312020-00026

    authors: Abe S,Mizusawa I,Kanno K,Yabashi A,Suto M,Kuraya M,Honda T,Hiraiwa K

    更新日期:2003-12-02 00:00:00

  • Ca2+ currents in cockroach neurones: properties and modulation by neurohormone D.

    abstract::In dorsal unpaired median (DUM) neurones isolated from the terminal ganglion of the cockroach Periplaneta americana two types of Ca2+ currents were found: a transient one activated by lower depolarizations (LVA) and a sustained one activated by higher voltage jumps (HVA). Both currents were strongly reduced by 100 mic...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199405000-00001

    authors: Wicher D,Penzlin H

    更新日期:1994-05-09 00:00:00

  • Auditory stimuli activate parietal brain regions: a whole-head MEG study.

    abstract::Previous studies using magnetoencephalographic (MEG) recordings have revealed neuronal populations responding to discrete auditory stimuli in the supratemporal cortex of the human brain. We used the novel whole-head magnetometer (Neuromag-122) to determine whether regions outside the auditory cortex are activated by a...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199412300-00046

    authors: Lavikainen J,Huotilainen M,Pekkonen E,Ilmoniemi RJ,Näätänen R

    更新日期:1994-12-30 00:00:00

  • Interference and facilitation in overt speech production investigated with event-related potentials.

    abstract::We report an event-related potential study investigating the neural basis of interference and facilitation in the picture-word interference paradigm with immediate overt naming. We used the high temporal resolution of the electrophysiological response to dissociate general and specific interference processes, by compa...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/WNR.0b013e328309ecd1

    authors: Hirschfeld G,Jansma B,Bölte J,Zwitserlood P

    更新日期:2008-08-06 00:00:00

  • Corticospinal projections from mesial frontal and cingulate areas in the monkey.

    abstract::We injected neural tracers into the lateral funiculus of the spinal cord in order to relate the sites of origin of the spinal projections from the mesial cortical surface with the cytoarchitectonic organization of this region. We found a close correlation between the origin sites and density of corticospinal projectio...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199412000-00035

    authors: Luppino G,Matelli M,Camarda R,Rizzolatti G

    更新日期:1994-12-20 00:00:00

  • Identification of short latency auditory responsive neurons in the cat dentate nucleus.

    abstract::Intracellular recordings of activity in response to acoustic stimuli were obtained from units of the dentate nucleus of conscious cats. Twelve units with short latency responses to 70 dB clicks or hisses were injected intracellularly with biocytin and identified morphologically. The identified cells were small, relati...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199408150-00006

    authors: Xi MC,Woody CD,Gruen E

    更新日期:1994-08-15 00:00:00

  • Event-related potentials for interaural time differences and spectral cues.

    abstract::Dichotic pitches and mistuned harmonics can each lead to the perception of one or two auditory objects. Comparison of event-related potentials for the perception of one versus two objects reveals an early negative and a late positive component. The relationship of these components with auditory segregation was further...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32832c92bf

    authors: Hautus MJ,Johnson BW,Colling LJ

    更新日期:2009-07-01 00:00:00

  • Perception and recognition discriminated in the mouse auditory cortex by c-Fos labeling.

    abstract::The functions of the fields of the mammalian auditory cortex in sound perception and recognition are unknown. We used Fos (a protein of the inducible immediate-early gene c-fos) as a cellular marker of activated brain areas to show in the mouse (Mus domesticus) that sound is processed differentially in auditory cortic...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199908020-00022

    authors: Fichtel I,Ehret G

    更新日期:1999-08-02 00:00:00

  • Nicotine facilitates noradrenaline release in the rat supraoptic nucleus.

    abstract::Nicotine injected in the supraoptic nucleus facilitates vasopressin release from the neurohypophysis. Nicotinic acetylcholine receptors have been found not only on vasopressin-producing cell bodies but also on presynaptic nerve terminals in the nucleus. Vasopressin cells receive excitatory synaptic inputs from noradre...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200103050-00042

    authors: Liu X,Onaka T,Yagi K

    更新日期:2001-03-05 00:00:00