Prenatal stress suppresses cell proliferation in the early developing brain.

Abstract:

:Although prenatal stress has been repeatedly shown to inhibit adult neurogenesis in the dentate gyrus of offspring, its effects on embryonic and early postnatal brain development are not well described. Here, using the cell proliferation marker 5-bromo-2'-deoxyuridine, we examine for the first time the effect of prenatal stress at the embryonic stage on cell proliferation in the hippocampus, nucleus accumbens and amygdala. We show that prenatal stress induces a significant decrease in density of 5-bromo-2'-deoxyuridine-positive cells in the nucleus accumbens (40%) and hippocampus (60%), and a nonsignificant decrease in the amygdala (30%). Taken together, these results demonstrate the adverse effects of prenatal maternal stress on early development in limbic brain regions and the potential mechanisms are discussed.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Kawamura T,Chen J,Takahashi T,Ichitani Y,Nakahara D

doi

10.1097/01.wnr.0000236849.53682.6d

subject

Has Abstract

pub_date

2006-10-02 00:00:00

pages

1515-8

issue

14

eissn

0959-4965

issn

1473-558X

pii

00001756-200610020-00012

journal_volume

17

pub_type

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