Abstract:
:Although prenatal stress has been repeatedly shown to inhibit adult neurogenesis in the dentate gyrus of offspring, its effects on embryonic and early postnatal brain development are not well described. Here, using the cell proliferation marker 5-bromo-2'-deoxyuridine, we examine for the first time the effect of prenatal stress at the embryonic stage on cell proliferation in the hippocampus, nucleus accumbens and amygdala. We show that prenatal stress induces a significant decrease in density of 5-bromo-2'-deoxyuridine-positive cells in the nucleus accumbens (40%) and hippocampus (60%), and a nonsignificant decrease in the amygdala (30%). Taken together, these results demonstrate the adverse effects of prenatal maternal stress on early development in limbic brain regions and the potential mechanisms are discussed.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kawamura T,Chen J,Takahashi T,Ichitani Y,Nakahara Ddoi
10.1097/01.wnr.0000236849.53682.6dsubject
Has Abstractpub_date
2006-10-02 00:00:00pages
1515-8issue
14eissn
0959-4965issn
1473-558Xpii
00001756-200610020-00012journal_volume
17pub_type
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