Amygdala beta-noradrenergic influence on hippocampal long-term potentiation in vivo.

Abstract:

:We have previously shown that hippocampal long-term potentiation (LTP), one form of synaptic plasticity that may underlie learning and memory, is attenuated by blocking neuron activity of the basolateral amygdala (BLA). In the present study we investigated the amygdala noradrenergic or cholinergic contribution to hippocampal LTP formation. When propranolol, a beta-adrenoceptor antagonist, was injected into the BLA 10 min before tetanus, the formation of LTP in the perforant path-dentate granule cell synapses was significantly impaired. Scopolamine, a muscarinic cholinergic receptor antagonist, did not affect the formation of LTP. These results suggest that amygdala beta-noradrenergic activity plays a critical role in modulation of hippocampal LTP.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Ikegaya Y,Nakanishi K,Saito H,Abe K

doi

10.1097/00001756-199709290-00027

subject

Has Abstract

pub_date

1997-09-29 00:00:00

pages

3143-6

issue

14

eissn

0959-4965

issn

1473-558X

journal_volume

8

pub_type

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